ppat phosphoribosyl pyrophosphate amidotransferase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ppatprovided by ZNC
Official Full Name: phosphoribosyl pyrophosphate amidotransferaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041210-323
See related: Ensembl:ENSDARG00000004517 AllianceGenome:ZFIN:ZDB-GENE-041210-323
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:6894693; wu:fb61f03; wu:fc28b09; si:dkeyp-117h8.5
Summary: Predicted to enable amidophosphoribosyltransferase activity. Predicted to be involved in purine nucleotide biosynthetic process. Predicted to act upstream of or within purine nucleobase biosynthetic process. Is expressed in several structures, including alar plate midbrain region; digestive system; nervous system; pectoral fin bud; and segmental plate. Orthologous to human PPAT (phosphoribosyl pyrophosphate amidotransferase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (25626208..25639278)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (25727118..25740188)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc08b11.x1 (e-PCR)
- UniSTS:192335

fb61f03.x1 (e-PCR)
- UniSTS:187304

fa20h06.s1 (e-PCR)
- UniSTS:202473

fc28b09.x1 (e-PCR)
- UniSTS:187894

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables amidophosphoribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables amidophosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' IMP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within purine nucleobase biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within purine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: amidophosphoribosyltransferase

NP_001076346.2

EC 2.4.2.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082877.2 → NP_001076346.2 amidophosphoribosyltransferase

See identical proteins and their annotated locations for NP_001076346.2

Status: PROVISIONAL

Source sequence(s)

BC146730

UniProtKB/TrEMBL

A6H8S4

Related

ENSDARP00000072847.4, ENSDART00000078385.6

Conserved Domains (3) summary

cd06223
Location:306 → 442

PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain

COG0034
Location:10 → 506

PurF; Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]

cd00715
Location:12 → 295

GPATase_N; Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the ...