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SPC25 SPC25 component of NDC80 kinetochore complex [ Homo sapiens (human) ]

Gene ID: 57405, updated on 27-Nov-2024

Summary

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Official Symbol
SPC25provided by HGNC
Official Full Name
SPC25 component of NDC80 kinetochore complexprovided by HGNC
Primary source
HGNC:HGNC:24031
See related
Ensembl:ENSG00000152253 MIM:609395; AllianceGenome:HGNC:24031
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AD024; SPBC25; hSpc25
Summary
This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 4.1), bone marrow (RPKM 2.8) and 19 other tissues See more
Orthologs
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Genomic context

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See SPC25 in Genome Data Viewer
Location:
2q24.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (168861521..168890430, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (169319011..169364874, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (169727401..169746940, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ceramide synthase 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:169471049-169471548 Neighboring gene RNA, U6 small nuclear 766, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16736 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:169592586-169593086 Neighboring gene CERS6 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 4310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:169658591-169659090 Neighboring gene nitric oxide synthase trafficking Neighboring gene uncharacterized LOC124907904 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:169764453-169765248 Neighboring gene glucose-6-phosphatase catalytic subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SPC25 Functions as a Prognostic-Related Biomarker, and Its High Expression Correlates with Tumor Immune Infiltration and UCEC Progression. Liao LX, et al. Front Biosci (Landmark Ed), 2024 Feb 20. PMID 38420826
  2. SPC25 as a novel therapeutic and prognostic biomarker and its association with glycolysis, ferroptosis and ceRNA in lung adenocarcinoma. Liu XS, et al. Aging (Albany NY), 2024 Jan 11. PMID 38217547, Free PMC Article
  3. SPC25 promotes proliferation and stemness of hepatocellular carcinoma cells via the DNA-PK/AKT/Notch1 signaling pathway. Yang J, et al. Int J Biol Sci, 2022. PMID 36147467, Free PMC Article
  4. Spindle pole body component 25 and platelet-derived growth factor mediate crosstalk between tumor-associated macrophages and prostate cancer cells. Cui F, et al. Front Immunol, 2022. PMID 35967419, Free PMC Article
  5. SPC25 upregulation increases cancer stem cell properties in non-small cell lung adenocarcinoma cells and independently predicts poor survival. Chen J, et al. Biomed Pharmacother, 2018 Apr. PMID 29432994

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PLEK2 activates the PI3K/AKT signaling pathway to drive lung adenocarcinoma progression by upregulating SPC25.
    Title: PLEK2 activates the PI3K/AKT signaling pathway to drive lung adenocarcinoma progression by upregulating SPC25.
  2. SPC25 Functions as a Prognostic-Related Biomarker, and Its High Expression Correlates with Tumor Immune Infiltration and UCEC Progression.
    Title: SPC25 Functions as a Prognostic-Related Biomarker, and Its High Expression Correlates with Tumor Immune Infiltration and UCEC Progression.
  3. SPC25 as a novel therapeutic and prognostic biomarker and its association with glycolysis, ferroptosis and ceRNA in lung adenocarcinoma.
    Title: SPC25 as a novel therapeutic and prognostic biomarker and its association with glycolysis, ferroptosis and ceRNA in lung adenocarcinoma.
  4. SPC25 promotes proliferation and stemness of hepatocellular carcinoma cells via the DNA-PK/AKT/Notch1 signaling pathway.
    Title: SPC25 promotes proliferation and stemness of hepatocellular carcinoma cells via the DNA-PK/AKT/Notch1 signaling pathway.
  5. Spindle pole body component 25 and platelet-derived growth factor mediate crosstalk between tumor-associated macrophages and prostate cancer cells.
    Title: Spindle pole body component 25 and platelet-derived growth factor mediate crosstalk between tumor-associated macrophages and prostate cancer cells.
  6. SPC25 promotes hepatocellular carcinoma metastasis via activating the FAK/PI3K/AKT signaling pathway through ITGB4.
    Title: SPC25 promotes hepatocellular carcinoma metastasis via activating the FAK/PI3K/AKT signaling pathway through ITGB4.
  7. SPC25 may promote proliferation and metastasis of hepatocellular carcinoma via p53.
    Title: SPC25 may promote proliferation and metastasis of hepatocellular carcinoma via p53.
  8. SPC25 overexpression promotes tumor proliferation and is prognostic of poor survival in hepatocellular carcinoma.
    Title: SPC25 overexpression promotes tumor proliferation and is prognostic of poor survival in hepatocellular carcinoma.
  9. These findings suggest that SPC25 levels are higher in more malignant breast cancer subtypes and are associated with poor prognosis in breast cancer patients
    Title: Up-regulation of SPC25 promotes breast cancer.
  10. These data suggest that SPC25 may be highly expressed in the CSC-like cells in PrC and could be a promising target for effective treatment of PrC.
    Title: Spindle pole body component 25 regulates stemness of prostate cancer cells.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC22228

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in attachment of spindle microtubules to kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromosome segregation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic spindle assembly checkpoint signaling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Ndc80 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ndc80 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Ndc80 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of outer kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kinetochore protein Spc25
Names
2600017H08Rik
SPC25, NDC80 kinetochore complex component, homolog
spindle pole body component 25 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020675.4 → NP_065726.1  kinetochore protein Spc25

    See identical proteins and their annotated locations for NP_065726.1

    Status: REVIEWED

    Source sequence(s)
    AC069137
    Consensus CDS
    CCDS2229.1
    UniProtKB/Swiss-Prot
    A8K4X8, D3DPC0, Q9HBM1
    Related
    ENSP00000282074.2, ENST00000282074.7
    Conserved Domains (2) summary
    pfam10186
    Location:26 → 127
    Atg14; Vacuolar sorting 38 and autophagy-related subunit 14
    pfam08234
    Location:149 → 218
    Spindle_Spc25; Chromosome segregation protein Spc25

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    168861521..168890430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511516.3 → XP_011509818.1  kinetochore protein Spc25 isoform X1

    See identical proteins and their annotated locations for XP_011509818.1

    Conserved Domains (1) summary
    pfam08234
    Location:149 → 183
    Spindle_Spc25; Chromosome segregation protein Spc25

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003315909.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    31163..77057 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329484.1 → XP_054185459.1  kinetochore protein Spc25 isoform X1

  2. XM_054329483.1 → XP_054185458.1  kinetochore protein Spc25 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    169319011..169364874 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343128.1 → XP_054199103.1  kinetochore protein Spc25 isoform X1

  2. XM_054343127.1 → XP_054199102.1  kinetochore protein Spc25 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HBM1.1 GenPept UniProtKB/Swiss-Prot:Q9HBM1

Gene LinkOut

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