futsch futsch [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: futschprovided by FlyBase
Official Full Name: futschprovided by FlyBase
Primary source: FLYBASE:FBgn0259108
Locus tag: Dmel_CG34387
See related: AllianceGenome:FB:FBgn0259108
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 22c10; 22C10; 22C10/FUTSCH; 22C20; CG14772; CG3064; CG34387; Dmel\CG34387; EG:49E4.1; Futch; Futsch; FUTSCH; lincRNA.936; mAb 22C10; Mab 22C10; mAb-22C10; mAb22c10; mAb22C10; Mab22c10; Mab22C10; MAb22C10; Map-1B; MAP-1b; MAP-IB; map1b; Map1B; MAP1B; olk; Olk; ssC10
Old locus tag: CG14772; CG3064; Dmel_CG14772; Dmel_CG3064
Summary: Enables kinase binding activity and microtubule binding activity. Involved in several processes, including cytoskeleton organization; neuron projection morphogenesis; and olfactory learning. Located in several cellular components, including dendrite; neuromuscular junction; and neuronal cell body. Part of microtubule associated complex. Is expressed in several structures, including chordotonal organ; ganglia; larval neurons; motor neurons; and sensory neurons. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness and periventricular nodular heterotopia. Orthologous to several human genes including MAP1A (microtubule associated protein 1A) and MAP1B (microtubule associated protein 1B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 2A2-2A3; 1-0.2 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (1409069..1453686)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (1303102..1347719)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

our data are in favor of a model by which Futsch locally stabilizes synaptic active zones, by reinforcing their link with the underlying microtubule cytoskeleton.
Title: A presynaptic role of microtubule-associated protein 1/Futsch in Drosophila: regulation of active zone number and neurotransmitter release.
TDP-43 physically interacts with futsch mRNA and that its RNA binding capacity is required to prevent futsch down regulation and synaptic defects.
Title: TDP-43 regulates Drosophila neuromuscular junctions growth by modulating Futsch/MAP1B levels and synaptic microtubules organization.
Microtubule-associated protein 1 function is fulfilled by light chain and heavy chain FUTSCH-encoded precursor polypeptide subunits, identified following proteolytic processing at a conserved cleavage site.
Title: MAP1 structural organization in Drosophila: in vivo analysis of FUTSCH reveals heavy- and light-chain subunits generated by proteolytic processing at a conserved cleavage site.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axo-dendritic transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite development	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurofilament cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
part_of microtubule associated complex	IBA Inferred from Biological aspect of Ancestor more info
part_of microtubule associated complex	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info