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CG34448 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 5740554, updated on 4-Jan-2025

Summary

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Official Symbol
CG34448provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0085477
Locus tag
Dmel_CG34448
See related
AllianceGenome:FB:FBgn0085477
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG31684; CG9966; Dmel\CG34448
Old locus tag
CG31684; Dmel_CG31684
Summary
Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); glucose metabolism disease (multiple); hypotrichosis 7; and obesity. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG34448 in Genome Data Viewer
Location:
22E1-22E1; 2-6 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2416792..2417965, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2416792..2417965, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Vesicular glutamate transporter Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Coordinated control of adiposity and growth by anti-anabolic kinase ERK7. Hasygar K, et al. EMBO Rep, 2021 Feb 3. PMID 33369866, Free PMC Article
  2. Quantitative Proteomics Identification of Seminal Fluid Proteins in Male Drosophila melanogaster. Sepil I, et al. Mol Cell Proteomics, 2019 Mar 15. PMID 30287546, Free PMC Article
  3. The expression pattern of the Drosophila vesicular glutamate transporter: a marker protein for motoneurons and glutamatergic centers in the brain. Mahr A, et al. Gene Expr Patterns, 2006 Mar. PMID 16378756
  4. Comparative and functional genomics of lipases in holometabolous insects. Horne I, et al. Insect Biochem Mol Biol, 2009 Aug. PMID 19540341
  5. Genomic regulatory blocks underlie extensive microsynteny conservation in insects. Engström PG, et al. Genome Res, 2007 Dec. PMID 17989259, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipase activity IEA
Inferred from Electronic Annotation
more info
  
enables triacylglycerol lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG34448-PA
NP_001097059.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2416792..2417965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103589.2 → NP_001097059.1  uncharacterized protein Dmel_CG34448 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097059.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYT7
    Conserved Domains (1) summary
    cd00707
    Location:44 → 316
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8DYT7 A8DYT7

Gene LinkOut

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