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nvd neverland [ Drosophila melanogaster (fruit fly) ]

Gene ID: 5740633, updated on 9-Dec-2024

Summary

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Official Symbol
nvdprovided by FlyBase
Official Full Name
neverlandprovided by FlyBase
Primary source
FLYBASE:FBgn0287185
Locus tag
Dmel_CG40050
See related
AllianceGenome:FB:FBgn0287185
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
80Fc; CG40050; Dmel\CG40050; l(3)80Fc; l(3)Lh6; l6; Nvd; NVD; nvd-Dm
Summary
Enables cholesterol 7-desaturase (NAD(P)H) activity. Involved in ecdysteroid biosynthetic process; instar larval development; and metamorphosis. Predicted to be active in cytoplasm. Is expressed in follicle cell; germline cyst; nurse cell; prothoracic gland; and ring gland. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See nvd in Genome Data Viewer
Location:
80F9-80F9; 3-47 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (24324866..24401655)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (24317966..24394755)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Synaptosomal-associated protein 25kDa Neighboring gene long non-coding RNA:CR45159 Neighboring gene pseudo Neighboring gene mitochondrial ribosomal protein S5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Soluble expression, purification and biochemical characterization of a C-7 cholesterol dehydrogenase from Drosophila melanogaster. Zhu Z, et al. Steroids, 2019 Dec. PMID 31521708
  2. Dual Roles of Glutathione in Ecdysone Biosynthesis and Antioxidant Function During Larval Development in Drosophila. Enya S, et al. Genetics, 2017 Dec. PMID 29021278, Free PMC Article
  3. Mutations in the neverland gene turned Drosophila pachea into an obligate specialist species. Lang M, et al. Science, 2012 Sep 28. PMID 23019649, Free PMC Article
  4. Neverland is an evolutionally conserved Rieske-domain protein that is essential for ecdysone synthesis and insect growth. Yoshiyama T, et al. Development, 2006 Jul. PMID 16763204
  5. Characterization of candidate intermediates in the Black Box of the ecdysone biosynthetic pathway in Drosophila melanogaster: Evaluation of molting activities on ecdysteroid-defective larvae. Saito J, et al. J Insect Physiol, 2016 Oct-Nov. PMID 27662806

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The neverland (nvd) gene encodes an oxygenase-like protein with a Rieske electron carrier domain, from the silkworm Bombyx mori and the fruitfly Drosophila melanogaster
    Title: Neverland is an evolutionally conserved Rieske-domain protein that is essential for ecdysone synthesis and insect growth.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

mobile_element

  • Loc: 24369119-24372918 mobile_element_type = transposon:Doc{}6512
  • Loc: 24376573-24377682 mobile_element_type = transposon:1360{}6364

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables cholesterol 7-desaturase (NAD(P)H) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ecdysteroid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in instar larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in metamorphosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
neverland
Names
CG40050-PA
lethal (3) 80Fc
lethal 6
lethal6
nvd-PA
NP_001097670.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    24324866..24401655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104200.3 → NP_001097670.1  neverland [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097670.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q1JUZ1, Q5BIG3
    Conserved Domains (1) summary
    cd03469
    Location:97 → 210
    Rieske_RO_Alpha_N; Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1JUZ1.1 Q1JUZ1

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