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CG17636 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 5740847, updated on 4-Jan-2025

Summary

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Official Symbol
CG17636provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0025837
Locus tag
Dmel_CG17636
See related
AllianceGenome:FB:FBgn0025837
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG17636; EG:23E12.1
Summary
Predicted to enable glutathione hydrolase activity. Predicted to be involved in glutathione catabolic process. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in gamma-glutamyl transpeptidase deficiency. Orthologous to several human genes including GGT1 (gamma-glutamyltransferase 1) and GGT2P (gamma-glutamyltransferase 2, pseudogene). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG17636 in Genome Data Viewer
Location:
1A1-1A1; 1-0 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (124370..126714, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20757..23101, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR40469 Neighboring gene Rho GTPase activating protein at 1A Neighboring gene mir-4915 stem loop Neighboring gene long non-coding RNA:CR45473 Neighboring gene trynity

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The conserved genetic program of male germ cells uncovers ancient regulators of human spermatogenesis. Brattig-Correia R, et al. Elife, 2024 Oct 10. PMID 39388236, Free PMC Article
  2. Topoisomerase 3β interacts with RNAi machinery to promote heterochromatin formation and transcriptional silencing in Drosophila. Lee SK, et al. Nat Commun, 2018 Nov 23. PMID 30470739, Free PMC Article
  3. Proteomic identification of Drosophila melanogaster male accessory gland proteins, including a pro-cathepsin and a soluble gamma-glutamyl transpeptidase. Walker MJ, et al. Proteome Sci, 2006 May 2. PMID 16670001, Free PMC Article
  4. An analysis of genetic changes during the divergence of Drosophila species. Sousa-Neves R, et al. PLoS One, 2010 May 5. PMID 20463966, Free PMC Article
  5. From first base: the sequence of the tip of the X chromosome of Drosophila melanogaster, a comparison of two sequencing strategies. Benos PV, et al. Genome Res, 2001 May. PMID 11337470, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables glutathione hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutathione catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG17636-PA
CG17636-PB
CG17636-PC
NP_001096854.1
NP_001245441.1
NP_001245442.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    124370..126714 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103384.3 → NP_001096854.1  uncharacterized protein Dmel_CG17636, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096854.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XZS5
    Conserved Domains (1) summary
    pfam01019
    Location:55 → 560
    G_glu_transpept; Gamma-glutamyltranspeptidase

  2. NM_001258513.2 → NP_001245442.1  uncharacterized protein Dmel_CG17636, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245442.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NFP5
    Conserved Domains (1) summary
    pfam01019
    Location:69 → 574
    G_glu_transpept; Gamma-glutamyltranspeptidase

  3. NM_001258512.2 → NP_001245441.1  uncharacterized protein Dmel_CG17636, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245441.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D5A7L0
    Conserved Domains (1) summary
    pfam01019
    Location:1 → 490
    G_glu_transpept; Gamma-glutamyltranspeptidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D5A7L0 D5A7L0
M9NFP5 M9NFP5
Q9XZS5 Q9XZS5

Gene LinkOut

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