Jmy junction-mediating and regulatory protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Jmyprovided by MGI
Official Full Name: junction-mediating and regulatory proteinprovided by MGI
Primary source: MGI:MGI:1913096
See related: Ensembl:ENSMUSG00000021690 AllianceGenome:MGI:1913096
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables transcription coactivator activity. Involved in actin nucleation; actin polymerization-dependent cell motility; and positive regulation of apoptotic process. Acts upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in skeletal muscle. Orthologous to human JMY (junction mediating and regulatory protein, p53 cofactor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 9.3), ovary adult (RPKM 8.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 C3; 13 47.85 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (93566605..93636316, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (93430097..93499808, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

JMY expression by Sertoli cells contributes to mediating spermatogenesis in mice.
Title: JMY expression by Sertoli cells contributes to mediating spermatogenesis in mice.
JMY activates MRTF-SRF independently of F-actin via WH2/V-mediated competition with the RPEL region for G-actin binding in the cytoplasm
Title: Regulation of MRTF-A by JMY via a nucleation-independent mechanism.
JMY drives vesicular trafficking in the trans-Golgi region and at ER-membrane contact sites, distinct from other Arp2/3 activators involved in vesicle transport processes such as the related WHAMM or WASH.
Title: JMY is involved in anterograde vesicle trafficking from the trans-Golgi network.
Results of the present study show that the nucleation-promoting factors JMY and WAVE2 are critical for cytokinesis during development of mouse embryos.
Title: Role of nucleation-promoting factors in mouse early embryo development.
JMY is required for spindle migration, asymmetric division and cytokinesis during mouse oocyte maturation.
Title: JMY is required for asymmetric division and cytokinesis in mouse oocytes.
The protein and messenger RNA levels of JMY were decreased in aged oocytes, but the levels were normal in caffeine-treated aged oocytes.
Title: Degradation of actin nucleators affects cortical polarity of aged mouse oocytes.
JMY is a modulator of neuritogenesis
Title: The actin nucleation factor JMY is a negative regulator of neuritogenesis.
These results define a new functional relationship between the p53 cofactor JMY and Mdm2, and indicate that transcription cofactors that facilitate p53 activity are important targets for Mdm2 in suppressing the p53 response.
Title: Mdm2 targets the p53 transcription cofactor JMY for degradation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237078

RH125038 (e-PCR)
- UniSTS:161860

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Arp2/3 complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in 'de novo' actin filament nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in 'de novo' actin filament nucleation	IDA Inferred from Direct Assay more info	PubMed
involved_in Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in Arp2/3 complex-mediated actin nucleation	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in actin polymerization-dependent cell motility	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway by p53 class mediator	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in autophagosome membrane	ISO Inferred from Sequence Orthology more info
located_in autophagosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: junction-mediating and -regulatory protein

Names: p300 transcriptional cofactor JMY

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021310.3 → NP_067285.2 junction-mediating and -regulatory protein

See identical proteins and their annotated locations for NP_067285.2

Status: VALIDATED

Source sequence(s)

AC154231, AK141957, BC090835

Consensus CDS

CCDS26688.1

UniProtKB/Swiss-Prot

Q3UQZ0, Q5BL16, Q6NST0, Q8CBP9, Q8VDZ3, Q9QXM1

UniProtKB/TrEMBL

A0A0R4J0V4

Related

ENSMUSP00000070339.8, ENSMUST00000065537.9

Conserved Domains (2) summary

pfam15871
Location:220 → 573

JMY; Junction-mediating and -regulatory protein

pfam15920
Location:6 → 54

WHAMM-JMY_N; N-terminal of Junction-mediating and WASP homolog-associated