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MUC3B mucin 3B, cell surface associated [ Homo sapiens (human) ]

Gene ID: 57876, updated on 2-Nov-2024

Summary

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Official Symbol
MUC3Bprovided by HGNC
Official Full Name
mucin 3B, cell surface associatedprovided by HGNC
Primary source
HGNC:HGNC:13384
See related
MIM:605633; AllianceGenome:HGNC:13384
Gene type
protein coding
RefSeq status
MODEL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MUC3; MUC3A
Summary
Predicted to be located in Golgi lumen and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: not annotated on reference assembly
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Genomic context

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See MUC3B in Genome Data Viewer
Location:
7q22
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (102269415..102273580)

Chromosome 7 - NC_060931.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375431 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100546705-100547685 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100547686-100548665 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:100548721-100549266 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:100551103-100551603 Neighboring gene mucin 3A, cell surface associated Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18472 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18473 Neighboring gene mucin-17-like Neighboring gene mucin 12, cell surface associated Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100641457-100642309 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100658552-100659220 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26395 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26396 Neighboring gene Sharpr-MPRA regulatory region 8701 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26397 Neighboring gene MUC12 antisense RNA 1 Neighboring gene mucin 17, cell surface associated Neighboring gene RN7SK pseudogene 54

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_060931.1 Chromosome 7 Alternate T2T-CHM13v2.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Discovery of a MUC3B gene reconstructs the membrane mucin gene cluster on human chromosome 7. Lang T, et al. PLoS One, 2022. PMID 36256656, Free PMC Article
  2. Initiation of transcription of the MUC3A human intestinal mucin from a TATA-less promoter and comparison with the MUC3B amino terminus. Gum JR Jr, et al. J Biol Chem, 2003 Dec 5. PMID 12958310
  3. Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease. Kyo K, et al. J Hum Genet, 2001. PMID 11289722
  4. Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B. Pratt WS, et al. Biochem Biophys Res Commun, 2000 Sep 7. PMID 10973822
  5. The MUC3 gene encodes a transmembrane mucin and is alternatively spliced. Williams SJ, et al. Biochem Biophys Res Commun, 1999 Jul 22. PMID 10405327

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Discovery of a MUC3B gene reconstructs the membrane mucin gene cluster on human chromosome 7.
    Title: Discovery of a MUC3B gene reconstructs the membrane mucin gene cluster on human chromosome 7.
  2. up-regulated MUC expression by synovial tissue cells and suggest a novel role of MUC3 and MUC5AC in the pathogenesis of arthritis
    Title: Expression of mucin 3 and mucin 5AC in arthritic synovial tissue.
  3. has highly conserved amino and carboxyl termini, suggesting a recent duplication of the entire ancestral gene
    Title: Initiation of transcription of the MUC3A human intestinal mucin from a TATA-less promoter and comparison with the MUC3B amino terminus.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in Golgi lumen TAS
Traceable Author Statement
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
mucin-3B
Names
MUC-3B
intestinal mucin MUC3B
intestinal mucin-3B

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    102269415..102273580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444977.1 → XP_047300933.1  mucin-3B

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H195.3 GenPept UniProtKB/Swiss-Prot:Q9H195

Gene LinkOut

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