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fech ferrochelatase [ Danio rerio (zebrafish) ]

Gene ID: 58215, updated on 4-Jan-2025

Summary

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Official Symbol
fechprovided by ZNC
Official Full Name
ferrochelataseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-000928-1
See related
Ensembl:ENSDARG00000003462 AllianceGenome:ZFIN:ZDB-GENE-000928-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fch; zgc:109851
Summary
Enables ferrochelatase activity. Acts upstream of or within erythrocyte maturation. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in blood; intermediate cell mass of mesoderm; kidney; posterior lateral plate mesoderm; and ventral mesoderm. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Orthologous to human FECH (ferrochelatase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See fech in Genome Data Viewer
Location:
chromosome: 21
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (1647915..1671436)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (1622195..1644440)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene vitelline membrane outer layer 1 homolog b Neighboring gene zgc:152948 Neighboring gene one cut homeobox 2 Neighboring gene uncharacterized LOC103909387

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Salicylic acid induces mitochondrial injury by inhibiting ferrochelatase heme biosynthesis activity. Gupta V, et al. Mol Pharmacol, 2013 Dec. PMID 24043703
  2. Morpholino phosphorodiamidate oligonucleotides in zebrafish: a recipe for functional genomics? Sumanas S, et al. Brief Funct Genomic Proteomic, 2002 Oct. PMID 15239891
  3. Hematopoietic mutations in the zebrafish. Weinstein BM, et al. Development, 1996 Dec. PMID 9007250
  4. Molecular evolution and expression of zebrafish St8SiaIII, an alpha-2,8-sialyltransferase involved in myotome development. Bentrop J, et al. Dev Dyn, 2008 Mar. PMID 18265011
  5. Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts. Shah DI, et al. Nature, 2012 Nov 22. PMID 23135403, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC109851

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ferrochelatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferrochelatase activity IEA
Inferred from Electronic Annotation
more info
  
enables ferrochelatase activity IMP
Inferred from Mutant Phenotype
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within erythrocyte maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within porphyrin-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ferrochelatase, mitochondrial
Names
dracula
drc
frx
NP_571706.1
XP_021324574.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131631.2 → NP_571706.1  ferrochelatase, mitochondrial

    Status: PROVISIONAL

    Source sequence(s)
    AF250368
    UniProtKB/TrEMBL
    Q9DFU9
    Related
    ENSDARP00000125028.1, ENSDART00000148540.2
    Conserved Domains (3) summary
    cd00419
    Location:221 → 358
    Ferrochelatase_C; Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
    cd03411
    Location:55 → 216
    Ferrochelatase_N; Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
    pfam00762
    Location:55 → 375
    Ferrochelatase; Ferrochelatase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    1647915..1671436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021468899.2 → XP_021324574.1  ferrochelatase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8M9PIE9
    Conserved Domains (1) summary
    pfam00762
    Location:55 → 375
    Ferrochelatase
Nucleotide Protein
Heading Accession and Version

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