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Stx6 syntaxin 6 [ Mus musculus (house mouse) ]

Gene ID: 58244, updated on 27-Nov-2024

Summary

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Official Symbol
Stx6provided by MGI
Official Full Name
syntaxin 6provided by MGI
Primary source
MGI:MGI:1926235
See related
Ensembl:ENSMUSG00000026470 AllianceGenome:MGI:1926235
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310039E05Rik; 2410005I16Rik
Summary
Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in regulation of protein localization. Acts upstream of or within endosome organization. Located in phagocytic vesicle and trans-Golgi network membrane. Orthologous to human STX6 (syntaxin 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 26.2), whole brain E14.5 (RPKM 15.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Stx6 in Genome Data Viewer
Location:
1 G3; 1 66.46 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (155034374..155083405)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (155158628..155207567)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41981 Neighboring gene predicted gene, 30922 Neighboring gene STARR-positive B cell enhancer ABC_E2569 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:157001032-157001362 Neighboring gene STARR-positive B cell enhancer ABC_E500 Neighboring gene major histocompatibility complex, class I-related Neighboring gene high mobility group protein B3 pseudogene Neighboring gene cDNA sequence BC034090 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:157081058-157081259 Neighboring gene predicted gene, 31102 Neighboring gene STARR-positive B cell enhancer ABC_E7760 Neighboring gene xenotropic and polytropic retrovirus receptor 1 Neighboring gene predicted gene, 17974

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Syntaxin-6 delays prion protein fibril formation and prolongs the presence of toxic aggregation intermediates. Sangar D, et al. Elife, 2024 Aug 7. PMID 39109999, Free PMC Article
  2. Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob disease risk gene Stx6. Jones E, et al. Neurobiol Dis, 2024 Jan. PMID 37996040, Free PMC Article
  3. Recycling of IRAP from the plasma membrane back to the insulin-responsive compartment requires the Q-SNARE syntaxin 6 but not the GGA clathrin adaptors. Watson RT, et al. J Cell Sci, 2008 Apr 15. PMID 18388312, Free PMC Article
  4. Cholesterol accumulation increases insulin granule size and impairs membrane trafficking. Bogan JS, et al. Traffic, 2012 Nov. PMID 22889194, Free PMC Article
  5. The C-terminus of GLUT4 targets the transporter to the perinuclear compartment but not to the insulin-responsive vesicles. Li LV, et al. Biochem J, 2009 Apr 1. PMID 19076072, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob disease risk gene Stx6.
    Title: Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob disease risk gene Stx6.
  2. Cholesterol modulates distribution of syntaxin 6 in insulin granule membranes.
    Title: Cholesterol accumulation increases insulin granule size and impairs membrane trafficking.
  3. a novel mechanism showing how Salmonella acquires LAMP1 through a SipC-Syntaxin6-mediated interaction probably to stabilize their niche in macrophages
    Title: Salmonella acquires lysosome-associated membrane protein 1 (LAMP1) on phagosomes from Golgi via SipC protein-mediated recruitment of host Syntaxin6.
  4. syntaxin 6 is required for rentry of IRAP from cell surface back into the insulin-responsive complex
    Title: Recycling of IRAP from the plasma membrane back to the insulin-responsive compartment requires the Q-SNARE syntaxin 6 but not the GGA clathrin adaptors.
  5. Syntaxin 6 and Vti1b form a SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis Factor-alpha
    Title: Syntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis Factor-alpha.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNAP receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables syntaxin binding IEA
Inferred from Electronic Annotation
more info
  
enables syntaxin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi vesicle transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within endocytic recycling ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytic recycling ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within endosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in synaptic vesicle to endosome fusion IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic vesicle to endosome fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic vesicle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in recycling endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
syntaxin-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021433.3 → NP_067408.1  syntaxin-6

    See identical proteins and their annotated locations for NP_067408.1

    Status: VALIDATED

    Source sequence(s)
    BM899312, BQ749205, BU613686, CF737112, CJ088919, CN456515, CX220575
    Consensus CDS
    CCDS35741.1
    UniProtKB/Swiss-Prot
    Q9D3A1, Q9D729, Q9JKK1
    UniProtKB/TrEMBL
    Q3UA21
    Related
    ENSMUSP00000027743.8, ENSMUST00000027743.13
    Conserved Domains (2) summary
    cd15851
    Location:166 → 231
    SNARE_Syntaxin6; SNARE motif of syntaxin 6
    pfam09177
    Location:13 → 103
    Syntaxin-6_N; Syntaxin 6, N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    155034374..155083405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529766.5 → XP_006529829.1  syntaxin-6 isoform X1

    UniProtKB/TrEMBL
    Q3UA21
    Related
    ENSMUSP00000141976.2, ENSMUST00000193059.6
    Conserved Domains (2) summary
    cd15851
    Location:166 → 231
    SNARE_Syntaxin6; SNARE motif of syntaxin 6
    pfam09177
    Location:13 → 103
    Syntaxin-6_N; Syntaxin 6, N-terminal

  2. XM_036152546.1 → XP_036008439.1  syntaxin-6 isoform X3

    Conserved Domains (1) summary
    cd15851
    Location:65 → 130
    SNARE_Syntaxin6; SNARE motif of syntaxin 6

  3. XM_017321868.3 → XP_017177357.1  syntaxin-6 isoform X2

    Conserved Domains (1) summary
    cd15851
    Location:65 → 130
    SNARE_Syntaxin6; SNARE motif of syntaxin 6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JKK1.1 GenPept UniProtKB/Swiss-Prot:Q9JKK1

Gene LinkOut

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