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Mest mesoderm specific transcript [ Rattus norvegicus (Norway rat) ]

Gene ID: 58827, updated on 27-Nov-2024

Summary

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Official Symbol
Mestprovided by RGD
Official Full Name
mesoderm specific transcriptprovided by RGD
Primary source
RGD:1594589
See related
EnsemblRapid:ENSRNOG00000048088 AllianceGenome:RGD:1594589
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable hydrolase activity. Predicted to be involved in regulation of lipid storage and response to retinoic acid. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human MEST (mesoderm specific transcript). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 272.4), Muscle (RPKM 177.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mest in Genome Data Viewer
Location:
4q22
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (60321814..60332288)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (59354445..59364919)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (58052786..58063227)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene carboxypeptidase A1 Neighboring gene centrosomal protein 41 Neighboring gene COPI coat complex subunit gamma 2 Neighboring gene uncharacterized LOC134486571 Neighboring gene testis specific, 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mesoderm-specific transcript is associated with fat mass expansion in response to a positive energy balance. Nikonova L, et al. FASEB J, 2008 Nov. PMID 18644838, Free PMC Article
  2. Retinoic acid receptor gamma activates receptor tyrosine kinase Tie1 gene transcription through transcription factor GATA4 in F9 stem cells. Su D, et al. Exp Hematol, 2008 May. PMID 18439490
  3. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC73011

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of lipid storage ISO
Inferred from Sequence Orthology
more info
  
involved_in response to retinoic acid ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mesoderm-specific transcript homolog protein
Names
mesoderm specific transcript homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009617.2 → NP_001009617.1  mesoderm-specific transcript homolog protein

    See identical proteins and their annotated locations for NP_001009617.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q6P5P5
    UniProtKB/TrEMBL
    M0R830
    Related
    ENSRNOP00000065620.3, ENSRNOT00000072698.4
    Conserved Domains (1) summary
    COG0596
    Location:47 → 321
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    60321814..60332288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P5P5.1 GenPept UniProtKB/Swiss-Prot:Q6P5P5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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