Nup210 nucleoporin 210 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nup210provided by RGD
Official Full Name: nucleoporin 210provided by RGD
Primary source: RGD:69339
See related: EnsemblRapid:ENSRNOG00000005390 AllianceGenome:RGD:69339
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pom210
Summary: Involved in protein-containing complex assembly. Predicted to be located in nuclear envelope. Predicted to be part of nuclear pore. Orthologous to human NUP210 (nucleoporin 210). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 163.7), Thymus (RPKM 115.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (125068736..125167238, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (123511558..123609874, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (122643952..122741322, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings are consistent with the idea that mitotic phosphorylation acts to dissociate gp210 from the structural elements of the nuclear pore complexes.
Title: Phosphomimetic mutation of the mitotically phosphorylated serine 1880 compromises the interaction of the transmembrane nucleoporin gp210 with the nuclear pore complex.

Submit: New GeneRIF Correction

General gene information

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Markers

STS-Z40910 (e-PCR)
- UniSTS:29447

UniSTS:224278 (e-PCR)
- UniSTS:224278

RH128192 (e-PCR)
- UniSTS:211500

AI836801 (e-PCR)
- UniSTS:179419

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables structural constituent of nuclear pore	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: nuclear pore membrane glycoprotein 210

Names: nuclear envelope pore membrane protein POM 210; nuclear pore protein gp210; nucleoporin Nup210; pore membrane protein of 210 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053322.3 → NP_445774.1 nuclear pore membrane glycoprotein 210 precursor

See identical proteins and their annotated locations for NP_445774.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

P11654

UniProtKB/TrEMBL

A6IB90

Related

ENSRNOP00000008888.3, ENSRNOT00000008888.6

Conserved Domains (1) summary

pfam02368
Location:1079 → 1152

Big_2; Bacterial Ig-like domain (group 2)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

125068736..125167238 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286649.1 → XP_063142719.1 nuclear pore membrane glycoprotein 210 isoform X2
XM_063286648.1 → XP_063142718.1 nuclear pore membrane glycoprotein 210 isoform X1