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Hpgds hematopoietic prostaglandin D synthase [ Rattus norvegicus (Norway rat) ]

Gene ID: 58962, updated on 27-Nov-2024

Summary

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Official Symbol
Hpgdsprovided by RGD
Official Full Name
hematopoietic prostaglandin D synthaseprovided by RGD
Primary source
RGD:69251
See related
EnsemblRapid:ENSRNOG00000006583 AllianceGenome:RGD:69251
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ptgds2
Summary
Predicted to enable several functions, including glutathione transferase activity; metal ion binding activity; and prostaglandin-D synthase activity. Predicted to be involved in glutathione metabolic process and prostaglandin metabolic process. Predicted to act upstream of or within negative regulation of male germ cell proliferation. Predicted to be located in cytosol and nucleoplasm. Orthologous to human HPGDS (hematopoietic prostaglandin D synthase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 1130.0), Thymus (RPKM 141.8) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Hpgds in Genome Data Viewer
Location:
4q31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (95698265..95727733, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (94368426..94397931, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (95945356..95970666, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene non-POU domain containing, octamer-binding, pseudogene 10 Neighboring gene SNF2 related chromatin remodeling ATPase with DExD box 1 Neighboring gene oxidized purine nucleoside triphosphate hydrolase-like Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta, pseudogene 4 Neighboring gene pyroglutamylated RFamide peptide receptor like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Prostaglandin D2 synthase inhibits the exaggerated growth phenotype of spontaneously hypertensive rat vascular smooth muscle cells. Ragolia L, et al. J Biol Chem, 2003 Jun 13. PMID 12684506
  2. Cloning and crystal structure of hematopoietic prostaglandin D synthase. Kanaoka Y, et al. Cell, 1997 Sep 19. PMID 9323136
  3. Post-translational modification regulates prostaglandin D2 synthase apoptotic activity: characterization by site-directed mutagenesis. Ragolia L, et al. Prostaglandins Other Lipid Mediat, 2007 Feb. PMID 17259069, Free PMC Article
  4. Mechanism of metal activation of human hematopoietic prostaglandin D synthase. Inoue T, et al. Nat Struct Biol, 2003 Apr. PMID 12627223
  5. Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Conservation of the ancestral genomic structure of sigma-class glutathione S-transferase. Kanaoka Y, et al. Eur J Biochem, 2000 Jun. PMID 10824118

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. L-PGDS is involved in the balance of VSMC proliferation and apoptosis
    Title: Prostaglandin D2 synthase inhibits the exaggerated growth phenotype of spontaneously hypertensive rat vascular smooth muscle cells.
  2. Post-translational modification of L-PGDS, by either glycosylation or phosphorylation, enhances its apoptotic activity and inhibits vascular smooth muscle cells hyperproliferation.
    Title: Post-translational modification regulates prostaglandin D2 synthase apoptotic activity: characterization by site-directed mutagenesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC105397

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables prostaglandin-D synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables prostaglandin-D synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables prostaglandin-D synthase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of male germ cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in prostaglandin biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within prostaglandin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in prostaglandin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in prostaglandin metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to nematode IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to nematode ISO
Inferred from Sequence Orthology
more info
  
involved_in response to selenium ion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to selenium ion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
hematopoietic prostaglandin D synthase
Names
GST class-sigma
H-PGDS
glutathione S-transferase
glutathione-dependent PGD synthase
glutathione-dependent PGD synthetase
glutathione-requiring prostaglandin D synthase
prostaglandin D2 synthase 2, hematopoietic
prostaglandin-H2 D-isomerase
NP_113832.1
XP_006236664.1
XP_006236665.1
XP_038964225.1
XP_063142720.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031644.2 → NP_113832.1  hematopoietic prostaglandin D synthase

    See identical proteins and their annotated locations for NP_113832.1

    Status: PROVISIONAL

    Source sequence(s)
    BC087590
    UniProtKB/Swiss-Prot
    O35351, O35543
    UniProtKB/TrEMBL
    A6KF23
    Related
    ENSRNOP00000008826.4, ENSRNOT00000008826.7
    Conserved Domains (2) summary
    cd10295
    Location:82 → 181
    GST_C_Sigma; C-terminal, alpha helical domain of Class Sigma Glutathione S-transferases
    cd03039
    Location:4 → 73
    GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    95698265..95727733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236603.5 → XP_006236665.1  hematopoietic prostaglandin D synthase isoform X2

    Conserved Domains (2) summary
    cd10295
    Location:51 → 151
    GST_C_Sigma; C-terminal, alpha helical domain of Class Sigma Glutathione S-transferases
    cd03039
    Location:4 → 43
    GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...

  2. XM_006236602.5 → XP_006236664.1  hematopoietic prostaglandin D synthase isoform X1

    Related
    ENSRNOP00000106939.1, ENSRNOT00000123843.1
    Conserved Domains (3) summary
    PTZ00057
    Location:3 → 198
    PTZ00057; glutathione s-transferase; Provisional
    cd10295
    Location:82 → 182
    GST_C_Sigma; C-terminal, alpha helical domain of Class Sigma Glutathione S-transferases
    cd03039
    Location:4 → 73
    GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...

  3. XM_063286650.1 → XP_063142720.1  hematopoietic prostaglandin D synthase isoform X3

  4. XM_039108297.2 → XP_038964225.1  hematopoietic prostaglandin D synthase isoform X4

    Conserved Domains (2) summary
    cd03039
    Location:4 → 73
    GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...
    cl02776
    Location:82 → 145
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35543.3 GenPept UniProtKB/Swiss-Prot:O35543

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