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Emcn endomucin [ Mus musculus (house mouse) ]

Gene ID: 59308, updated on 27-Nov-2024

Summary

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Official Symbol
Emcnprovided by MGI
Official Full Name
endomucinprovided by MGI
Primary source
MGI:MGI:1891716
See related
Ensembl:ENSMUSG00000054690 AllianceGenome:MGI:1891716
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Muc14; 0610012K22Rik
Summary
Predicted to enable carbohydrate binding activity. Acts upstream of or within hematopoietic stem cell homeostasis. Predicted to be located in plasma membrane. Is expressed in several structures, including cardiovascular system; early conceptus; hemolymphoid system; lung; and urinary system. Orthologous to human EMCN (endomucin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in kidney adult (RPKM 46.9), heart adult (RPKM 22.7) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Emcn in Genome Data Viewer
Location:
3 G3; 3 63.65 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (137046824..137136830)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (137341062..137431069)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26107 Neighboring gene STARR-seq mESC enhancer starr_09083 Neighboring gene STARR-seq mESC enhancer starr_09084 Neighboring gene STARR-positive B cell enhancer ABC_E9225 Neighboring gene predicted gene 567 Neighboring gene predicted gene, 38650 Neighboring gene STARR-seq mESC enhancer starr_09085 Neighboring gene predicted gene 4861 Neighboring gene DNA-damage-inducible transcript 4-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Endomucin marks quiescent long-term multi-lineage repopulating hematopoietic stem cells and is essential for their transendothelial migration. Engelhard S, et al. Cell Rep, 2024 Jul 23. PMID 38996072
  2. Endomucin is expressed in embryonic dorsal aorta and is able to inhibit cell adhesion. Ueno M, et al. Biochem Biophys Res Commun, 2001 Sep 21. PMID 11554756
  3. Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development. Matsubara A, et al. J Exp Med, 2005 Dec 5. PMID 16314436, Free PMC Article
  4. Biochemical characterization and molecular cloning of a novel endothelial-specific sialomucin. Morgan SM, et al. Blood, 1999 Jan 1. PMID 9864158
  5. Non-endothelial expression of endomucin in the mouse and human choroid. Brookins E, et al. Exp Eye Res, 2024 Oct. PMID 39153592,

See all (298) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Non-endothelial expression of endomucin in the mouse and human choroid.
    Title: Non-endothelial expression of endomucin in the mouse and human choroid.
  2. Deficiency of Omentin-1 leads to delayed fracture healing through excessive inflammation and reduced CD31(hi)Emcn(hi) vessels.
    Title: Deficiency of Omentin-1 leads to delayed fracture healing through excessive inflammation and reduced CD31(hi)Emcn(hi) vessels.
  3. Taken together, it seems likely that endomucin-reactive small blood vessels extended to the podoplanin/E11/gp38-positive odontoblast layers, whereas endomucin-reactive large blood vessels were already present in CD44-immmunopositive sub-odontoblastic layer, indicating the cellular regulation on the vascularization of endomucin-reactive endothelial cells during odontogenesis of the tooth germs.
    Title: Immunolocalization of podoplanin/E11/gp38, CD44, and endomucin in the odontoblastic cell layer of murine tooth germs.
  4. These results indicate that endomucin prevents leukocyte contact with adhesion molecules in non-inflamed tissues and that downregulation of endomucin is critical to facilitate adhesion of leukocytes into inflamed tissues.
    Title: Endomucin prevents leukocyte-endothelial cell adhesion and has a critical role under resting and inflammatory conditions.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
endomucin
Names
MUC-14
endomucin-1
endomucin-1/2
mucin 14, endothelial
mucin-14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163522.1 → NP_001156994.1  endomucin isoform 1 precursor

    See identical proteins and their annotated locations for NP_001156994.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA822842, BC003706
    Consensus CDS
    CCDS51075.1
    UniProtKB/Swiss-Prot
    Q78KL2, Q9DCN9, Q9R0H2, Q9ULC1, Q9Z2I1
    UniProtKB/TrEMBL
    A0A0G2JDR2
    Related
    ENSMUSP00000112603.2, ENSMUST00000122064.8
    Conserved Domains (1) summary
    pfam07010
    Location:1 → 261
    Endomucin; Endomucin

  2. NM_016885.2 → NP_058581.2  endomucin isoform 2 precursor

    See identical proteins and their annotated locations for NP_058581.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AA822842, AK002616, BC003706
    Consensus CDS
    CCDS17861.1
    UniProtKB/TrEMBL
    A0A0G2JDR2
    Related
    ENSMUSP00000114102.2, ENSMUST00000119475.6
    Conserved Domains (1) summary
    pfam07010
    Location:1 → 248
    Endomucin; Endomucin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    137046824..137136830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501842.4 → XP_006501905.1  endomucin isoform X1

    See identical proteins and their annotated locations for XP_006501905.1

    UniProtKB/TrEMBL
    A0A0G2JDR2
    Related
    ENSMUSP00000142467.2, ENSMUST00000197511.2
    Conserved Domains (1) summary
    pfam07010
    Location:1 → 223
    Endomucin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0H2.1 GenPept UniProtKB/Swiss-Prot:Q9R0H2

Gene LinkOut

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