Shank3 SH3 and multiple ankyrin repeat domains 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 59312, updated on 27-Nov-2024

Summary

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Official Symbol: Shank3provided by RGD
Official Full Name: SH3 and multiple ankyrin repeat domains 3provided by RGD
Primary source: RGD:69264
See related: EnsemblRapid:ENSRNOG00000052296 AllianceGenome:RGD:69264
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Prosap2; Spank-2
Summary: Enables several functions, including SH3 domain binding activity; scaffold protein binding activity; and synaptic receptor adaptor activity. A structural constituent of postsynaptic density. Involved in positive regulation of glutamate receptor signaling pathway and regulation of postsynapse organization. Located in ciliary membrane. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Used to study Phelan-McDermid syndrome. Human ortholog(s) of this gene implicated in Phelan-McDermid syndrome and schizophrenia 15. Orthologous to human SHANK3 (SH3 and multiple ankyrin repeat domains 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 83.5), Brain (RPKM 54.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Shank3 in Genome Data Viewer

Location:: 7q34

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (122448323..122518623)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (120568707..120630796)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (130474278..130534679)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Clustering of CaV 1.3 L-type calcium channels by Shank3.
Title: Clustering of Ca(V) 1.3 L-type calcium channels by Shank3.
A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling.
Title: A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling.
Autism-associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses.
Title: Autism-associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses.
Reduced brain volume and white matter alterations in Shank3-deficient rats.
Title: Reduced brain volume and white matter alterations in Shank3-deficient rats.
Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats.
Title: Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats.
Shank3 contributes to neuropathic pain by facilitating the SNI-dependent increase of HCN2 and the expression of PSD95.
Title: Shank3 contributes to neuropathic pain by facilitating the SNI-dependent increase of HCN2 and the expression of PSD95.
Dynamic Change of Shanks Gene mRNA Expression and DNA Methylation in Epileptic Rat Model and Human Patients.
Title: Dynamic Change of Shanks Gene mRNA Expression and DNA Methylation in Epileptic Rat Model and Human Patients.
CaMKIIalpha phosphorylation of Shank3 modulates ABI1-Shank3 interaction.
Title: CaMKIIα phosphorylation of Shank3 modulates ABI1-Shank3 interaction.
Autism-Associated Shank3 Is Essential for Homeostatic Compensation in Rodent V1.
Title: Autism-Associated Shank3 Is Essential for Homeostatic Compensation in Rodent V1.
Our data show that the specific perturbation in mGluR-dependent synaptic plasticity occurs in rat neurons expressing autism spectrum disorders-associated Shank3 mutations
Title: Autism-associated Shank3 mutations alter mGluR expression and mGluR-dependent but not NMDA receptor-dependent long-term depression.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE108630 (e-PCR)
- UniSTS:247822

RH143496 (e-PCR)
- UniSTS:232743

D7Got127 (e-PCR)
- UniSTS:112432

BF405313 (e-PCR)
- UniSTS:247877

D7Wox53 (e-PCR)
- UniSTS:518629

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables SH3 domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables actin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ionotropic glutamate receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ionotropic glutamate receptor binding	IEA Inferred from Electronic Annotation more info
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables ionotropic glutamate receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of postsynaptic density	IEA Inferred from Electronic Annotation more info
enables structural constituent of postsynaptic density	IMP Inferred from Mutant Phenotype more info	PubMed
enables structural constituent of postsynaptic density	ISO Inferred from Sequence Orthology more info
enables synaptic receptor adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables synaptic receptor adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in AMPA glutamate receptor clustering	IEA Inferred from Electronic Annotation more info
involved_in AMPA glutamate receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in AMPA glutamate receptor clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in NMDA glutamate receptor clustering	IEA Inferred from Electronic Annotation more info
involved_in NMDA glutamate receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in NMDA glutamate receptor clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in adult behavior	ISO Inferred from Sequence Orthology more info
involved_in associative learning	IEA Inferred from Electronic Annotation more info
involved_in associative learning	ISO Inferred from Sequence Orthology more info
involved_in brain morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in brain morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in brain morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in dendritic spine morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in dendritic spine morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic epithelial tube formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic epithelial tube formation	ISO Inferred from Sequence Orthology more info
involved_in exploration behavior	ISO Inferred from Sequence Orthology more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in glial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in glial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in guanylate kinase-associated protein clustering	IEA Inferred from Electronic Annotation more info
involved_in guanylate kinase-associated protein clustering	ISO Inferred from Sequence Orthology more info
involved_in guanylate kinase-associated protein clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in learning	ISO Inferred from Sequence Orthology more info
involved_in learning	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within learning or memory	ISO Inferred from Sequence Orthology more info
involved_in locomotion	IEA Inferred from Electronic Annotation more info
involved_in locomotion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in locomotory exploration behavior	IEA Inferred from Electronic Annotation more info
involved_in locomotory exploration behavior	ISO Inferred from Sequence Orthology more info
involved_in locomotory exploration behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in long-term synaptic depression	IEA Inferred from Electronic Annotation more info
involved_in long-term synaptic depression	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in maintenance of postsynaptic density structure	IEA Inferred from Electronic Annotation more info
involved_in memory	IEA Inferred from Electronic Annotation more info
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in memory	ISS Inferred from Sequence or Structural Similarity more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of actin filament bundle assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of actin filament bundle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell volume	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell volume	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell volume	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural precursor cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular process controlling balance	IEA Inferred from Electronic Annotation more info
involved_in neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular process controlling balance	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of dendritic spine development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glutamate receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glutamate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of long-term neuronal synaptic plasticity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of long-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term neuronal synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term synaptic potentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synapse structural plasticity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synapse structural plasticity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse structural plasticity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in postsynaptic density assembly	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic density assembly	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic density assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of AMPA glutamate receptor clustering	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of AMPA glutamate receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in regulation of behavioral fear response	IEA Inferred from Electronic Annotation more info
involved_in regulation of behavioral fear response	ISO Inferred from Sequence Orthology more info
involved_in regulation of behavioral fear response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of dendritic spine morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendritic spine morphogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of grooming behavior	IEA Inferred from Electronic Annotation more info
involved_in regulation of grooming behavior	ISO Inferred from Sequence Orthology more info
involved_in regulation of long-term synaptic depression	IEA Inferred from Electronic Annotation more info
involved_in regulation of long-term synaptic depression	ISO Inferred from Sequence Orthology more info
involved_in regulation of long-term synaptic depression	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of long-term synaptic potentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in response to interleukin-17	IEA Inferred from Electronic Annotation more info
involved_in response to interleukin-17	ISO Inferred from Sequence Orthology more info
involved_in social behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within social behavior	ISO Inferred from Sequence Orthology more info
involved_in social behavior	ISO Inferred from Sequence Orthology more info
involved_in social behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in striatal medium spiny neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in striatal medium spiny neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in striatal medium spiny neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in synapse organization	IEA Inferred from Electronic Annotation more info
involved_in vocal learning	ISO Inferred from Sequence Orthology more info
involved_in vocalization behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vocalization behavior	ISO Inferred from Sequence Orthology more info
involved_in vocalization behavior	ISO Inferred from Sequence Orthology more info
involved_in vocalization behavior	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in ciliary membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info
located_in neuron spine	IEA Inferred from Electronic Annotation more info
located_in neuron spine	ISO Inferred from Sequence Orthology more info
located_in neuron spine	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane bounded cell projection	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: SH3 and multiple ankyrin repeat domains protein 3

Names: SH3/ankyrin domain gene 3; Shank postsynaptic density protein 3a; proline-rich synapse-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021676.4 → NP_067708.2 SH3 and multiple ankyrin repeat domains protein 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q9JLU4, Q9WUY7, Q9WV47

UniProtKB/TrEMBL

A0A0U1RS13

Related

ENSRNOP00000080578.2, ENSRNOT00000092413.3

Conserved Domains (9) summary

cd09506
Location:1739 → 1804

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PHA03307
Location:1036 → 1396

PHA03307; transcriptional regulator ICP4; Provisional

COG0666
Location:200 → 392

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

PRK12323
Location:1239 → 1429

PRK12323; DNA polymerase III subunit gamma/tau

cd00992
Location:647 → 736

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:257 → 288

ANK; ANK repeat [structural motif]

pfam12796
Location:329 → 410

Ank_2; Ankyrin repeats (3 copies)

cl17036
Location:548 → 599

SH3; Src Homology 3 domain superfamily

cl28922
Location:83 → 169

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

122448323..122518623

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063264179.1 → XP_063120249.1 SH3 and multiple ankyrin repeat domains protein 3 isoform X5
XM_039079820.2 → XP_038935748.1 SH3 and multiple ankyrin repeat domains protein 3 isoform X2

UniProtKB/Swiss-Prot

Q9JLU4, Q9WUY7, Q9WV47

Conserved Domains (8) summary

cd11984
Location:548 → 599

SH3_Shank3; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 3

PHA03307
Location:1036 → 1396

PHA03307; transcriptional regulator ICP4; Provisional

COG0666
Location:200 → 392

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

PRK12323
Location:1239 → 1429

PRK12323; DNA polymerase III subunit gamma/tau

cd00992
Location:647 → 736

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:257 → 288

ANK; ANK repeat [structural motif]

pfam12796
Location:329 → 410

Ank_2; Ankyrin repeats (3 copies)

cl28922
Location:83 → 169

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_039079822.2 → XP_038935750.1 SH3 and multiple ankyrin repeat domains protein 3 isoform X4

UniProtKB/Swiss-Prot

Q9JLU4, Q9WUY7, Q9WV47

UniProtKB/TrEMBL

A0A8I5ZTC4

Conserved Domains (8) summary

PHA03307
Location:1036 → 1396

PHA03307; transcriptional regulator ICP4; Provisional

COG0666
Location:200 → 392

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

PRK12323
Location:1239 → 1429

PRK12323; DNA polymerase III subunit gamma/tau

cd00992
Location:647 → 736

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:257 → 288

ANK; ANK repeat [structural motif]

pfam12796
Location:329 → 410

Ank_2; Ankyrin repeats (3 copies)

cl17036
Location:548 → 599

SH3; Src Homology 3 domain superfamily

cl28922
Location:83 → 169

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_039079826.2 → XP_038935754.1 SH3 and multiple ankyrin repeat domains protein 3 isoform X7

UniProtKB/TrEMBL

A0A0U1RS08

Conserved Domains (6) summary

cd11984
Location:548 → 599

SH3_Shank3; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 3

COG0666
Location:200 → 392

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00992
Location:647 → 736

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:257 → 288

ANK; ANK repeat [structural motif]

cd17177
Location:83 → 169

FERM_F0_SHANK3; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 3 (SHANK3)

pfam12796
Location:329 → 410

Ank_2; Ankyrin repeats (3 copies)
XM_063264180.1 → XP_063120250.1 SH3 and multiple ankyrin repeat domains protein 3 isoform X6
XM_039079818.2 → XP_038935746.1 SH3 and multiple ankyrin repeat domains protein 3 isoform X1

UniProtKB/Swiss-Prot

Q9JLU4, Q9WUY7, Q9WV47

UniProtKB/TrEMBL

A0A0U1RRP5

Related

ENSRNOP00000075760.3, ENSRNOT00000092431.3

Conserved Domains (9) summary

cd09506
Location:1731 → 1796

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PHA03247
Location:970 → 1425

PHA03247; large tegument protein UL36; Provisional

COG0666
Location:200 → 392

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

PRK12323
Location:1231 → 1421

PRK12323; DNA polymerase III subunit gamma/tau

cd00992
Location:647 → 736

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:257 → 288

ANK; ANK repeat [structural motif]

pfam12796
Location:329 → 410

Ank_2; Ankyrin repeats (3 copies)

cl17036
Location:548 → 599

SH3; Src Homology 3 domain superfamily

cl28922
Location:83 → 169

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_039079821.2 → XP_038935749.1 SH3 and multiple ankyrin repeat domains protein 3 isoform X3

UniProtKB/Swiss-Prot

Q9JLU4, Q9WUY7, Q9WV47

Related

ENSRNOP00000071295.2, ENSRNOT00000085191.3

Conserved Domains (8) summary

PHA03307
Location:1036 → 1396

PHA03307; transcriptional regulator ICP4; Provisional

COG0666
Location:200 → 392

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

PRK12323
Location:1239 → 1429

PRK12323; DNA polymerase III subunit gamma/tau

cd00992
Location:647 → 736

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:257 → 288

ANK; ANK repeat [structural motif]

pfam12796
Location:329 → 410

Ank_2; Ankyrin repeats (3 copies)

cl17036
Location:548 → 599

SH3; Src Homology 3 domain superfamily

cl28922
Location:83 → 169

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_063264181.1 → XP_063120251.1 SH3 and multiple ankyrin repeat domains protein 3 isoform X8