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SENP2 SUMO specific peptidase 2 [ Homo sapiens (human) ]

Gene ID: 59343, updated on 27-Nov-2024

Summary

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Official Symbol
SENP2provided by HGNC
Official Full Name
SUMO specific peptidase 2provided by HGNC
Primary source
HGNC:HGNC:23116
See related
Ensembl:ENSG00000163904 MIM:608261; AllianceGenome:HGNC:23116
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AXAM2; SMT3IP2
Summary
SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]
Expression
Broad expression in testis (RPKM 37.1), brain (RPKM 13.4) and 24 other tissues See more
Orthologs
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Genomic context

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See SENP2 in Genome Data Viewer
Location:
3q27.2
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (185586295..185633551)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (188402099..188449380)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (185304083..185351339)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374254 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14975 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20925 Neighboring gene lipase H Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20926 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185272617-185273292 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:185280735-185281348 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185281349-185281962 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185300277-185301176 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185302322-185302941 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185302942-185303560 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185303561-185304179 Neighboring gene ribosomal protein L34 pseudogene 10 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:185359885-185360103 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185363553-185364440 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:185369908-185370106 Neighboring gene insulin like growth factor 2 mRNA binding protein 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:185406257-185407456 Neighboring gene IGF2BP2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185442702-185443202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185445539-185446390 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185446391-185447242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185449611-185450110 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14976 Neighboring gene uncharacterized LOC124906313 Neighboring gene Sharpr-MPRA regulatory region 9603 Neighboring gene Sharpr-MPRA regulatory region 5696

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SENP2 regulates hepatocellular carcinoma cell growth by modulating the stability of β-catenin. Shen HJ, et al. Asian Pac J Cancer Prev, 2012. PMID 23098437
  2. Sumo-regulatory SENP2 controls the homeostatic squamous mitosis-differentiation checkpoint. Galán-Vidal J, et al. Cell Death Dis, 2024 Aug 16. PMID 39152119, Free PMC Article
  3. The SUMO-specific isopeptidase SENP2 is targeted to intracellular membranes via a predicted N-terminal amphipathic α-helix. Odeh HM, et al. Mol Biol Cell, 2018 Aug 1. PMID 29874116, Free PMC Article
  4. SUMO1/sentrin/SMT3 specific peptidase 2 modulates target molecules and its corresponding functions. Liu SL, et al. Biochimie, 2018 Sep. PMID 29908207
  5. Mitochondrial SENP2 regulates the assembly of SDH complex under metabolic stress. Liu Y, et al. Cell Rep, 2023 Feb 28. PMID 36708515

See all (120) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sumo-regulatory SENP2 controls the homeostatic squamous mitosis-differentiation checkpoint.
    Title: Sumo-regulatory SENP2 controls the homeostatic squamous mitosis-differentiation checkpoint.
  2. Extracellular vesicle-mediated regulation of imatinib resistance in chronic myeloid leukemia via the miR-629-5p/SENP2/PI3K/AKT/mTOR axis.
    Title: Extracellular vesicle-mediated regulation of imatinib resistance in chronic myeloid leukemia via the miR-629-5p/SENP2/PI3K/AKT/mTOR axis.
  3. Mitochondrial SENP2 regulates the assembly of SDH complex under metabolic stress.
    Title: Mitochondrial SENP2 regulates the assembly of SDH complex under metabolic stress.
  4. SENP2 regulates mitochondrial function and insulin secretion in pancreatic beta cells.
    Title: SENP2 regulates mitochondrial function and insulin secretion in pancreatic β cells.
  5. Hepatic Small Ubiquitin-Related Modifier (SUMO)-Specific Protease 2 Controls Systemic Metabolism Through SUMOylation-Dependent Regulation of Liver-Adipose Tissue Crosstalk.
    Title: Hepatic Small Ubiquitin-Related Modifier (SUMO)-Specific Protease 2 Controls Systemic Metabolism Through SUMOylation-Dependent Regulation of Liver-Adipose Tissue Crosstalk.
  6. Silencing of SENP2 in Multiple Myeloma Induces Bortezomib Resistance by Activating NF-kappaB Through the Modulation of IkappaBalpha Sumoylation.
    Title: Silencing of SENP2 in Multiple Myeloma Induces Bortezomib Resistance by Activating NF-κB Through the Modulation of IκBα Sumoylation.
  7. Overexpression of SENP2 was correlated with a better overall survival of the Gastric Cancer patients with a marginally significance, indicating that SENP2 expression could be used as a novel biomarker to predict patient prognosis.
    Title: Comprehensive Analysis of the Canonical and Non-canonical Wnt Signaling Pathways in Gastric Cancer.
  8. SENP2 regulates its substrate for desumoylation, and also the role of SENP2 in TGF-beta induced cancer cell migration.
    Title: The role of sentrin-specific protease 2 substrate recognition in TGF-β-induced tumorigenesis.
  9. he nuclear factor (NF)kappaB signaling pathway was also regulated by the overexpression of SENP2. On the whole, the findings of this study indicate tha SENP2 can act as a tumor suppressor in CLL cells, and may thus prove to be a novel target for CLL treatment in clinical practice.
    Title: SENP2 exerts an anti‑tumor effect on chronic lymphocytic leukemia cells through the inhibition of the Notch and NF‑κB signaling pathways.
  10. SENP2 is amplified as part of the chromosome 3q amplification in many cancers and Increased SENP2 expression prolongs MDC1 focus retention and increases NHEJ and radioresistance
    Title: The deSUMOylase SENP2 coordinates homologous recombination and nonhomologous end joining by independent mechanisms.
Submit: New GeneRIF Correction See all GeneRIFs (39)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1331, DKFZp762A2316

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SUMO-specific endopeptidase activity EXP
Inferred from Experiment
more info
 PubMed 
enables SUMO-specific endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables deSUMOylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein destabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein desumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein desumoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein desumoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein sumoylation TAS
Traceable Author Statement
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Wnt signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with PML body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sentrin-specific protease 2
Names
SMT3-specific isopeptidase 2
SUMO1/sentrin/SMT3 specific peptidase 2
SUMO1/sentrin/SMT3 specific protease 2
sentrin (SUMO1) specific peptidase 2
sentrin/SUMO-specific protease SENP2
NP_067640.2
XP_005247747.2
XP_005247748.1
XP_054203397.1
XP_054203398.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021627.3 → NP_067640.2  sentrin-specific protease 2

    See identical proteins and their annotated locations for NP_067640.2

    Status: VALIDATED

    Source sequence(s)
    AC016961, AF151697, AL834380, BC018020, BC040609
    Consensus CDS
    CCDS33902.1
    UniProtKB/Swiss-Prot
    B4DQ42, Q8IW97, Q96SR2, Q9HC62, Q9P2L5
    UniProtKB/TrEMBL
    B4E2S4
    Related
    ENSP00000296257.5, ENST00000296257.10
    Conserved Domains (1) summary
    COG5160
    Location:384 → 589
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    185586295..185633551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247690.4 → XP_005247747.2  sentrin-specific protease 2 isoform X1

    UniProtKB/TrEMBL
    B4E2S4
    Conserved Domains (1) summary
    cl23802
    Location:370 → 540
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  2. XM_005247691.4 → XP_005247748.1  sentrin-specific protease 2 isoform X2

    UniProtKB/TrEMBL
    B4DKY9
    Conserved Domains (1) summary
    cl23802
    Location:221 → 469
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    188402099..188449380
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347422.1 → XP_054203397.1  sentrin-specific protease 2 isoform X1

  2. XM_054347423.1 → XP_054203398.1  sentrin-specific protease 2 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HC62.3 GenPept UniProtKB/Swiss-Prot:Q9HC62

Gene LinkOut

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