Rhd Rh blood group, D antigen [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rhdprovided by RGD
Official Full Name: Rh blood group, D antigenprovided by RGD
Primary source: RGD:620451
See related: EnsemblRapid:ENSRNOG00000017130 AllianceGenome:RGD:620451
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rh; Rhced
Summary: Predicted to enable ammonium channel activity. Predicted to be involved in ammonium homeostasis and ammonium transmembrane transport. Predicted to act upstream of or within erythrocyte development and multicellular organismal-level iron ion homeostasis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Rh isoimmunization. Orthologous to several human genes including RHD (Rh blood group D antigen). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Restricted expression toward (RPKM 483.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (152371160..152405396)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (147087479..147121716)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (153197416..153232009)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ammonium channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ammonium homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ammonium transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ammonium transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within erythrocyte development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: blood group Rh(D) polypeptide

Names: Rhesus blood group CE and D; erythrocyte membrane glycoprotein Rh30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429898.1 → NP_001416827.1 blood group Rh(D) polypeptide isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A6IT38
NM_022505.3 → NP_071950.1 blood group Rh(D) polypeptide isoform 1

See identical proteins and their annotated locations for NP_071950.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

O88298

UniProtKB/TrEMBL

A6IT38

Related

ENSRNOP00000023187.4, ENSRNOT00000023187.7

Conserved Domains (1) summary

cl03012
Location:46 → 397

Ammonium_transp; Ammonium Transporter Family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

152371160..152405396

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006239268.4 → XP_006239330.1 blood group Rh(D) polypeptide isoform X1

Conserved Domains (1) summary

cl03012
Location:46 → 275

Ammonium_transp; Ammonium Transporter Family
XM_039110697.2 → XP_038966625.1 blood group Rh(D) polypeptide isoform X2

Conserved Domains (1) summary

cl03012
Location:49 → 226

Ammonium_transp; Ammonium Transporter Family