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Doc2g double C2, gamma [ Mus musculus (house mouse) ]

Gene ID: 60425, updated on 27-Nov-2024

Summary

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Official Symbol
Doc2gprovided by MGI
Official Full Name
double C2, gammaprovided by MGI
Primary source
MGI:MGI:1926250
See related
Ensembl:ENSMUSG00000024871 AllianceGenome:MGI:1926250
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D830013O18Rik
Summary
Predicted to enable metal ion binding activity. Acts upstream of or within spontaneous neurotransmitter secretion. Predicted to be located in membrane and presynapse. Predicted to be active in synapse. Is expressed in central nervous system and retina. Orthologous to human DOC2GP (double C2 domain gamma, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in heart adult (RPKM 156.3), frontal lobe adult (RPKM 65.6) and 1 other tissue See more
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Genomic context

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See Doc2g in Genome Data Viewer
Location:
19 A; 19 3.72 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4053385..4057005)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4003385..4007005)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene T-box 10 Neighboring gene nudix hydrolase 8 Neighboring gene NADH:ubiquinone oxidoreductase core subunit V1 Neighboring gene STARR-positive B cell enhancer ABC_E2517 Neighboring gene glutathione S-transferase, pi 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Doc2gamma, a third isoform of double C2 protein, lacking calcium-dependent phospholipid binding activity. Fukuda M, et al. Biochem Biophys Res Commun, 2000 Sep 24. PMID 11027523
  2. Ca(2+) sensor proteins in spontaneous release and synaptic plasticity: Limited contribution of Doc2c, rabphilin-3a and synaptotagmin 7 in hippocampal glutamatergic neurons. Bourgeois-Jaarsma Q, et al. Mol Cell Neurosci, 2021 Apr. PMID 33753311
  3. Doc2 supports spontaneous synaptic transmission by a Ca(2+)-independent mechanism. Pang ZP, et al. Neuron, 2011 Apr 28. PMID 21521611, Free PMC Article
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Readthrough Gm49405

Readthrough gene: Gm49405, Included gene: Nudt8

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium-dependent activation of synaptic vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spontaneous neurotransmitter secretion IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
double C2-like domain-containing protein gamma
Names
doc2-gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021791.3 → NP_068563.2  double C2-like domain-containing protein gamma

    See identical proteins and their annotated locations for NP_068563.2

    Status: VALIDATED

    Source sequence(s)
    BC061104
    Consensus CDS
    CCDS29409.1
    UniProtKB/Swiss-Prot
    Q6P8R8, Q9ESN1
    UniProtKB/TrEMBL
    A0A0R4J053
    Related
    ENSMUSP00000025806.4, ENSMUST00000025806.5
    Conserved Domains (2) summary
    cd04035
    Location:84 → 209
    C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
    cl14603
    Location:246 → 378
    C2; C2 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    4053385..4057005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ESN1.1 GenPept UniProtKB/Swiss-Prot:Q9ESN1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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