TTTY2 testis expressed transcript, Y-linked 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TTTY2provided by HGNC
Official Full Name: testis expressed transcript, Y-linked 2provided by HGNC
Primary source: HGNC:HGNC:14023
See related: Ensembl:ENSG00000212855 AllianceGenome:HGNC:14023
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TTY2; lINC00109; NCRNA00109
Expression: Biased expression in gall bladder (RPKM 3.9), testis (RPKM 1.4) and 1 other tissue See more
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Genomic context

Location:: Yp11.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	Y	NC_000024.10 (9736286..9758476)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	Y	NC_060948.1 (10044989..10067190)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	Y	NC_000024.9 (9573895..9596085)

Chromosome Y - NC_000024.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that TTY2 gene family TTY2L2A and TTY2L12A deletions can be considered as one of the genetic risk factors for non-obstructive azoospermia.
Title: TTY2 genes deletions as genetic risk factor of male infertility.
Results indicate that the TTTY2 gene family may play a significant role in spermatogenesis and suggest a possible mechanism of nonhomologous recombinational events that may cause genomic instability and ultimately lead to male infertility.
Title: High frequency of TTTY2-like gene-related deletions in patients with idiopathic oligozoospermia and azoospermia.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

G66137 (e-PCR)
- UniSTS:229975

G65854 (e-PCR)
- UniSTS:230520

G34978 (e-PCR)
- UniSTS:37555

SHGC-102520 (e-PCR)
- UniSTS:168905

Other Names

long intergenic non-protein coding RNA 109
testis-specific testis transcript Y 2
testis-specific transcript, Y-linked 2 (non-protein coding)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.