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Kifbp kinesin family binding protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 606294, updated on 27-Nov-2024

Summary

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Official Symbol
Kifbpprovided by RGD
Official Full Name
kinesin family binding proteinprovided by RGD
Primary source
RGD:1593126
See related
EnsemblRapid:ENSRNOG00000000395 AllianceGenome:RGD:1593126
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kbp; Kif1bp
Summary
Predicted to enable kinesin binding activity and protein sequestering activity. Predicted to be involved in microtubule cytoskeleton organization; mitochondrion transport along microtubule; and plasma membrane bounded cell projection organization. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in Goldberg-Shprintzen syndrome. Orthologous to human KIFBP (kinesin family binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 225.3), Kidney (RPKM 130.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kifbp in Genome Data Viewer
Location:
20q11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (31055625..31075232, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (30512899..30532504, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (32191731..32211295, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene serglycin Neighboring gene large ribosomal subunit protein eL39-like Neighboring gene uncharacterized LOC134483921 Neighboring gene DExD-box helicase 21 Neighboring gene DExD-box helicase 50

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The novel protein KBP regulates mitochondria localization by interaction with a kinesin-like protein. Wozniak MJ, et al. BMC Cell Biol, 2005 Oct 14. PMID 16225668, Free PMC Article
  2. KBP interacts with SCG10, linking Goldberg-Shprintzen syndrome to microtubule dynamics and neuronal differentiation. Alves MM, et al. Hum Mol Genet, 2010 Sep 15. PMID 20621975, Free PMC Article
  3. Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice. Wilson R, et al. Wellcome Open Res, 2016. PMID 27996060, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables kinesin binding IEA
Inferred from Electronic Annotation
more info
  
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein sequestering activity IEA
Inferred from Electronic Annotation
more info
  
enables protein sequestering activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in central nervous system projection neuron axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion transport along microtubule IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrion transport along microtubule ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion transport along microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron projection maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transport along microtubule ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
KIF-binding protein
Names
KIF1 binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031627.1 → NP_001026797.1  KIF-binding protein

    See identical proteins and their annotated locations for NP_001026797.1

    Status: VALIDATED

    Source sequence(s)
    BC060521, BC098692
    UniProtKB/Swiss-Prot
    Q4G074
    UniProtKB/TrEMBL
    A6K453, G3V614
    Related
    ENSRNOP00000000444.6, ENSRNOT00000000444.9
    Conserved Domains (1) summary
    pfam12309
    Location:243 → 609
    KBP_C; KIF-1 binding protein C terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    31055625..31075232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099049.2 → XP_038954977.1  KIF-binding protein isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZUA6
    Related
    ENSRNOP00000082090.1, ENSRNOT00000103307.2
    Conserved Domains (1) summary
    pfam12309
    Location:243 → 293
    KBP_C; KIF-1 binding protein C terminal

  2. XM_063279488.1 → XP_063135558.1  KIF-binding protein isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4G074.1 GenPept UniProtKB/Swiss-Prot:Q4G074

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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