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IFS2 2-hydroxyisoflavanone synthase [ Glycine max (soybean) ]

Gene ID: 606705, updated on 3-Feb-2025

Summary

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Gene symbol
IFS2
Gene description
2-hydroxyisoflavanone synthase
Locus tag
GLYMA_13G173500v4
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Glycine max
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade; NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Glycine; Glycine subgen. Soja
Also known as
IFS1; CYP93C1v2
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Genomic context

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See IFS2 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2025_01 current Glycine_max_v4.0 (GCF_000004515.6) 13 NC_038249.2 (28182456..28184534)
103 previous assembly Glycine_max_v2.1 (GCF_000004515.5) 13 NC_038249.1 (28761503..28763581)

Chromosome 13 - NC_038249.2Genomic Context describing neighboring genes Neighboring gene 2-hydroxyisoflavanone synthase-like Neighboring gene uncharacterized LOC100780130 Neighboring gene isoflavone 4'-O-methyltransferase Neighboring gene isoflavone 4'-O-methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cytosine Methylation of Isoflavone Synthase Gene in the Genic Region Positively Regulates Its Expression and Isoflavone Biosynthesis in Soybean Seeds. Gupta OP, et al. DNA Cell Biol, 2019 Jun. PMID 31017480
  2. Genistein production in rice seed via transformation with soybean IFS genes. Sohn SI, et al. Plant Sci, 2014 Mar. PMID 24467893
  3. RNA interference of soybean isoflavone synthase genes leads to silencing in tissues distal to the transformation site and to enhanced susceptibility to Phytophthora sojae. Subramanian S, et al. Plant Physiol, 2005 Apr. PMID 15778457, Free PMC Article
  4. Isoflavonoid biosynthesis and accumulation in developing soybean seeds. Dhaubhadel S, et al. Plant Mol Biol, 2003 Dec. PMID 15082922
  5. Molecular characterization of the enzyme catalyzing the aryl migration reaction of isoflavonoid biosynthesis in soybean. Steele CL, et al. Arch Biochem Biophys, 1999 Jul 1. PMID 10375412

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cytosine Methylation of both isoforms of the Isoflavone Synthase Gene Positively Regulates Its Expression and Isoflavone Biosynthesis in Soybean Seeds
    Title: Cytosine Methylation of Isoflavone Synthase Gene in the Genic Region Positively Regulates Its Expression and Isoflavone Biosynthesis in Soybean Seeds.
  2. IFS2 is anchored in the endoplasmic reticulum and is involved in the isoflavonoid metabolon.
    Title: Twin anchors of the soybean isoflavonoid metabolon: evidence for tethering of the complex to the endoplasmic reticulum by IFS and C4H.
  3. Southern blot analysis of eight transgenic rice plants reveals that the transgenic plants have one to three copies of both the soybean IFS1 or IFS2 genes.
    Title: Genistein production in rice seed via transformation with soybean IFS genes.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
2-hydroxyisoflavanone synthase
Names
Cytochrome P450 93C1v2
cytochrome P450 monooxygenase CYP93C1v2p
isoflavone synthase 2
max cytochrome P450 monooxygenase CYP93C1
NP_001238515.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001251586.2 → NP_001238515.2  2-hydroxyisoflavanone synthase

    Status: VALIDATED

    Source sequence(s)
    ACUP04004714, AK245122
    UniProtKB/Swiss-Prot
    Q9SWR5
    UniProtKB/TrEMBL
    A0A411P320, B5L5F6, K9LH71
    Conserved Domains (1) summary
    cd20655
    Location:68 → 509
    CYP93; cytochrome P450 family 93

RefSeqs of Annotated Genomes: GCF_000004515.6-RS_2025_01

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Glycine_max_v4.0 Primary Assembly

Genomic

  1. NC_038249.2 Reference Glycine_max_v4.0 Primary Assembly

    Range
    28182456..28184534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SWR5.1 GenPept UniProtKB/Swiss-Prot:Q9SWR5

Gene LinkOut

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Molecular Biology Databases