Slc6a17 solute carrier family 6 member 17 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc6a17provided by RGD
Official Full Name: solute carrier family 6 member 17provided by RGD
Primary source: RGD:1587185
See related: EnsemblRapid:ENSRNOG00000050090 AllianceGenome:RGD:1587185
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ntt4
Summary: Predicted to enable symporter activity. Involved in neutral amino acid transport and protein catabolic process. Located in synaptic vesicle. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic vesicle membrane. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 48. Orthologous to human SLC6A17 (solute carrier family 6 member 17). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 239.2), Heart (RPKM 80.7) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (197795622..197843883, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (195107434..195155697, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (210249663..210299770, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data of this results suggested that the B0AT3 transporter have a role in regulation of monoaminergic as well as glutamatergic synapses.
Title: Characterization of the transporterB0AT3 (Slc6a17) in the rodent central nervous system.
Expression of Slc6a17 increases ~9-fold at night in the rat pineal gland. Expression appears to be regulated by neural mechanisms involving norepinephrine and cyclic AMP signaling.
Title: Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.
The substrate profile of the NTT4/XT1-dependent activity is similar to that of the closely related B(0)AT2/SBAT1 (SLC6A15), including a submillimolar apparent affinity for proline and leucine and a low millimolar apparent affinity for glutamine.
Title: Synaptic Vesicle Protein NTT4/XT1 (SLC6A17) Catalyzes Na+-coupled Neutral Amino Acid Transport.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136805 (e-PCR)
- UniSTS:218894

RH137842 (e-PCR)
- UniSTS:219929

RH144290 (e-PCR)
- UniSTS:233535

RH135159 (e-PCR)
- UniSTS:218436

D2Rat259 (e-PCR), detects polymorphism
- UniSTS:227400

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-leucine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-leucine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in alanine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in alanine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in brain development	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter transport	IEA Inferred from Electronic Annotation more info
involved_in neutral amino acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in proline transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in proline transport	IDA Inferred from Direct Assay more info	PubMed
involved_in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sodium-dependent neutral amino acid transporter SLC6A17

Names: orphan sodium- and chloride-dependent neurotransmitter transporter NTT4; sodium-dependent neurotransmitter transporter NTT4; solute carrier family 6 (neurotransmitter transporter), member 17; solute carrier family 6 (neutral amino acid transporter), member 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033079.2 → NP_001028251.1 sodium-dependent neutral amino acid transporter SLC6A17

See identical proteins and their annotated locations for NP_001028251.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P31662

UniProtKB/TrEMBL

A6HUU3

Related

ENSRNOP00000065179.1, ENSRNOT00000075653.4

Conserved Domains (1) summary

cd11521
Location:60 → 648

SLC6sbd_NTT4; Na(+)-dependent neurotransmitter transporter 4; solute-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

197795622..197843883 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063282444.1 → XP_063138514.1 sodium-dependent neutral amino acid transporter SLC6A17 isoform X1

UniProtKB/Swiss-Prot

P31662
XM_063282445.1 → XP_063138515.1 sodium-dependent neutral amino acid transporter SLC6A17 isoform X1

UniProtKB/Swiss-Prot

P31662