RPL17 ribosomal protein L17 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RPL17provided by HGNC
Official Full Name: ribosomal protein L17provided by HGNC
Primary source: HGNC:HGNC:10307
See related: Ensembl:ENSG00000265681 MIM:603661; AllianceGenome:HGNC:10307
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: L17; PD-1; uL22; RPL23
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL23 because the encoded protein shares amino acid identity with ribosomal protein L23 from Halobacterium marismortui; however, its official symbol is RPL17. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream C18orf32 (chromosome 18 open reading frame 32) gene. [provided by RefSeq, Dec 2010]
Expression: Ubiquitous expression in ovary (RPKM 688.1), bone marrow (RPKM 341.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 18q21.1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	18	NC_000018.10 (49488481..49492465, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	18	NC_060942.1 (49686222..49690206, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	18	NC_000018.9 (47014851..47018835, complement)

Chromosome 18 - NC_000018.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An atypical form of 60S ribosomal subunit in Diamond-Blackfan anemia linked to RPL17 variants.
Title: An atypical form of 60S ribosomal subunit in Diamond-Blackfan anemia linked to RPL17 variants.
The present study combines an individual-based phenotypic profiling with a transdiagnostic approach and shows that several ribosomal genes including RPL17 is involved in stress vulnerability across nonclinical and clinical conditions.
Title: Integrated profiling of phenotype and blood transcriptome for stress vulnerability and depression.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L17 (RPL17), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Gag-Pol	gag-pol	Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L17 (RPL17), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Nef	nef	Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L17 (RPL17), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Pr55(Gag)	gag	Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L17 (RPL17), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Rev	rev	HIV-1 Rev interacting protein, ribosomal protein L17 (RPL17), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells	PubMed
Tat	tat	Expression of HIV-1 Tat upregulates the abundance of ribosomal protein L17 (RPL17) in the nucleoli of Jurkat T-cells	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D18S1247 (e-PCR)
- UniSTS:31603

D17S1714 (e-PCR)
- UniSTS:79056

Readthrough RPL17-C18orf32

Readthrough gene: RPL17-C18orf32, Included gene: C18orf32

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of ribosome	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoplasmic translation	IC Inferred by Curator more info	PubMed
involved_in cytoplasmic translation	NAS Non-traceable Author Statement more info	PubMed
involved_in translation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
part_of cytosolic large ribosomal subunit	HDA more info	PubMed
part_of cytosolic large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic large ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic large ribosomal subunit	IPI Inferred from Physical Interaction more info	PubMed
located_in cytosolic ribosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: large ribosomal subunit protein uL22

Names: 60S ribosomal protein L17; 60S ribosomal protein L23; gene encoding putative NFkB activating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_000985.5 → NP_000976.1 large ribosomal subunit protein uL22 isoform a

See identical proteins and their annotated locations for NP_000976.1

Status: REVIEWED

Source sequence(s)

AC100778

Consensus CDS

CCDS45865.1

UniProtKB/Swiss-Prot

B2R4H3, B4E3C2, B5ME31, J3QL51, P18621, Q3KQW2, Q6NZ54, Q7M4M5

UniProtKB/TrEMBL

J3KRX5

Related

ENSP00000463842.1, ENST00000579408.5

Conserved Domains (1) summary

PTZ00178
Location:1 → 165

PTZ00178; 60S ribosomal protein L17; Provisional
NM_001035006.5 → NP_001030178.1 large ribosomal subunit protein uL22 isoform a

See identical proteins and their annotated locations for NP_001030178.1

Status: REVIEWED

Source sequence(s)

AC100778

Consensus CDS

CCDS45865.1

UniProtKB/Swiss-Prot

B2R4H3, B4E3C2, B5ME31, J3QL51, P18621, Q3KQW2, Q6NZ54, Q7M4M5

UniProtKB/TrEMBL

J3KRX5

Related

ENSP00000462385.1, ENST00000580261.6

Conserved Domains (1) summary

PTZ00178
Location:1 → 165

PTZ00178; 60S ribosomal protein L17; Provisional
NM_001199340.2 → NP_001186269.1 large ribosomal subunit protein uL22 isoform a

See identical proteins and their annotated locations for NP_001186269.1

Status: REVIEWED

Source sequence(s)

AC100778

Consensus CDS

CCDS45865.1

UniProtKB/Swiss-Prot

B2R4H3, B4E3C2, B5ME31, J3QL51, P18621, Q3KQW2, Q6NZ54, Q7M4M5

UniProtKB/TrEMBL

J3KRX5

Conserved Domains (1) summary

PTZ00178
Location:1 → 165

PTZ00178; 60S ribosomal protein L17; Provisional
NM_001199341.3 → NP_001186270.1 large ribosomal subunit protein uL22 isoform a

See identical proteins and their annotated locations for NP_001186270.1

Status: REVIEWED

Source sequence(s)

AC100778

Consensus CDS

CCDS45865.1

UniProtKB/Swiss-Prot

B2R4H3, B4E3C2, B5ME31, J3QL51, P18621, Q3KQW2, Q6NZ54, Q7M4M5

UniProtKB/TrEMBL

J3KRX5

Related

ENSP00000462023.1, ENST00000579248.5

Conserved Domains (1) summary

PTZ00178
Location:1 → 165

PTZ00178; 60S ribosomal protein L17; Provisional
NM_001199342.3 → NP_001186271.1 large ribosomal subunit protein uL22 isoform a

See identical proteins and their annotated locations for NP_001186271.1

Status: REVIEWED

Source sequence(s)

AC100778

Consensus CDS

CCDS45865.1

UniProtKB/Swiss-Prot

B2R4H3, B4E3C2, B5ME31, J3QL51, P18621, Q3KQW2, Q6NZ54, Q7M4M5

UniProtKB/TrEMBL

J3KRX5

Related

ENSP00000480555.1, ENST00000618613.5

Conserved Domains (1) summary

PTZ00178
Location:1 → 165

PTZ00178; 60S ribosomal protein L17; Provisional
NM_001199343.3 → NP_001186272.1 large ribosomal subunit protein uL22 isoform a

See identical proteins and their annotated locations for NP_001186272.1

Status: REVIEWED

Source sequence(s)

AC100778

Consensus CDS

CCDS45865.1

UniProtKB/Swiss-Prot

B2R4H3, B4E3C2, B5ME31, J3QL51, P18621, Q3KQW2, Q6NZ54, Q7M4M5

UniProtKB/TrEMBL

J3KRX5

Related

ENSP00000462203.1, ENST00000583637.5

Conserved Domains (1) summary

PTZ00178
Location:1 → 165

PTZ00178; 60S ribosomal protein L17; Provisional
NM_001199344.3 → NP_001186273.1 large ribosomal subunit protein uL22 isoform a

See identical proteins and their annotated locations for NP_001186273.1

Status: REVIEWED

Source sequence(s)

AC100778

Consensus CDS

CCDS45865.1

UniProtKB/Swiss-Prot

B2R4H3, B4E3C2, B5ME31, J3QL51, P18621, Q3KQW2, Q6NZ54, Q7M4M5

UniProtKB/TrEMBL

J3KRX5

Related

ENSP00000463885.1, ENST00000578532.5

Conserved Domains (1) summary

PTZ00178
Location:1 → 165

PTZ00178; 60S ribosomal protein L17; Provisional
NM_001199345.2 → NP_001186274.1 large ribosomal subunit protein uL22 isoform b

See identical proteins and their annotated locations for NP_001186274.1

Status: REVIEWED

Source sequence(s)

AC100778

Consensus CDS

CCDS56070.1

UniProtKB/Swiss-Prot

P18621

Related

ENSP00000462944.1, ENST00000581373.5

Conserved Domains (1) summary

PTZ00178
Location:1 → 127

PTZ00178; 60S ribosomal protein L17; Provisional
NM_001369555.1 → NP_001356484.1 large ribosomal subunit protein uL22 isoform c

Status: REVIEWED

Source sequence(s)

AC100778

UniProtKB/TrEMBL

J3KRX5

Conserved Domains (1) summary

PTZ00178
Location:1 → 170

PTZ00178; 60S ribosomal protein L17; Provisional
NM_001369556.1 → NP_001356485.1 large ribosomal subunit protein uL22 isoform a

Status: REVIEWED

Source sequence(s)

AC100778

Consensus CDS

CCDS45865.1

UniProtKB/Swiss-Prot

B2R4H3, B4E3C2, B5ME31, J3QL51, P18621, Q3KQW2, Q6NZ54, Q7M4M5

UniProtKB/TrEMBL

J3KRX5

Related

ENSP00000482577.1, ENST00000618619.4

Conserved Domains (1) summary

PTZ00178
Location:1 → 165

PTZ00178; 60S ribosomal protein L17; Provisional
NM_001369557.1 → NP_001356486.1 large ribosomal subunit protein uL22 isoform a

Status: REVIEWED

Source sequence(s)

AC100778

Consensus CDS

CCDS45865.1

UniProtKB/Swiss-Prot

B2R4H3, B4E3C2, B5ME31, J3QL51, P18621, Q3KQW2, Q6NZ54, Q7M4M5

UniProtKB/TrEMBL

J3KRX5

Conserved Domains (1) summary

PTZ00178
Location:1 → 165

PTZ00178; 60S ribosomal protein L17; Provisional
NM_001369558.1 → NP_001356487.1 large ribosomal subunit protein uL22 isoform a

Status: REVIEWED

Source sequence(s)

AC100778

Consensus CDS

CCDS45865.1

UniProtKB/Swiss-Prot

B2R4H3, B4E3C2, B5ME31, J3QL51, P18621, Q3KQW2, Q6NZ54, Q7M4M5

UniProtKB/TrEMBL

J3KRX5

Conserved Domains (1) summary

PTZ00178
Location:1 → 165

PTZ00178; 60S ribosomal protein L17; Provisional
NM_001369560.1 → NP_001356489.1 large ribosomal subunit protein uL22 isoform d

Status: REVIEWED

Source sequence(s)

AC100778

Consensus CDS

CCDS92461.1

UniProtKB/TrEMBL

J3KRX5, J3QLC8

Related

ENSP00000463490.1, ENST00000580210.5

Conserved Domains (1) summary

PTZ00178
Location:4 → 155

PTZ00178; 60S ribosomal protein L17; Provisional
NM_001369561.1 → NP_001356490.1 large ribosomal subunit protein uL22 isoform d

Status: REVIEWED

Source sequence(s)

AC100778

Consensus CDS

CCDS92461.1

UniProtKB/TrEMBL

J3KRX5, J3QLC8

Conserved Domains (1) summary

PTZ00178
Location:4 → 155

PTZ00178; 60S ribosomal protein L17; Provisional
NM_001369562.1 → NP_001356491.1 large ribosomal subunit protein uL22 isoform b

Status: REVIEWED

Source sequence(s)

AC100778

Consensus CDS

CCDS56070.1

Conserved Domains (1) summary

PTZ00178
Location:1 → 127

PTZ00178; 60S ribosomal protein L17; Provisional
NM_001369563.1 → NP_001356492.1 large ribosomal subunit protein uL22 isoform b

Status: REVIEWED

Source sequence(s)

AC100778

Consensus CDS

CCDS56070.1

Related

ENST00000584364.5

Conserved Domains (1) summary

PTZ00178
Location:1 → 127

PTZ00178; 60S ribosomal protein L17; Provisional