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Rgs21 regulator of G-protein signalling 21 [ Mus musculus (house mouse) ]

Gene ID: 624910, updated on 9-Dec-2024

Summary

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Official Symbol
Rgs21provided by MGI
Official Full Name
regulator of G-protein signalling 21provided by MGI
Primary source
MGI:MGI:3645243
See related
Ensembl:ENSMUSG00000098509 AllianceGenome:MGI:3645243
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EG624910
Summary
Involved in sensory perception of taste and transmission of nerve impulse. Orthologous to human RGS21 (regulator of G protein signaling 21). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human all
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Genomic context

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See Rgs21 in Genome Data Viewer
Location:
1 F; 1 62.66 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (144392388..144443185, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (144519690..144567667, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02538 Neighboring gene regulator of G-protein signaling 1 Neighboring gene STARR-positive B cell enhancer ABC_E5816 Neighboring gene predicted gene 7266 Neighboring gene STARR-seq mESC enhancer starr_02539 Neighboring gene STARR-seq mESC enhancer starr_02540 Neighboring gene regulator of G-protein signaling 18 Neighboring gene STARR-seq mESC enhancer starr_02541 Neighboring gene cytokine receptor-like factor 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The stability of tastant detection by mouse lingual chemosensory tissue requires Regulator of G protein Signaling-21 (RGS21). Schroer AB, et al. Chem Senses, 2021 Jan 1. PMID 34718440, Free PMC Article
  2. Development of Full Sweet, Umami, and Bitter Taste Responsiveness Requires Regulator of G protein Signaling-21 (RGS21). Schroer AB, et al. Chem Senses, 2018 May 23. PMID 29701767, Free PMC Article
  3. RGS21, a regulator of taste and mucociliary clearance? Kimple AJ, et al. Laryngoscope, 2014 Mar. PMID 23908053, Free PMC Article
  4. Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia. Cohen SP, et al. J Biol Chem, 2012 Dec 7. PMID 23095746, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The stability of tastant detection by mouse lingual chemosensory tissue requires Regulator of G protein Signaling-21 (RGS21).
    Title: The stability of tastant detection by mouse lingual chemosensory tissue requires Regulator of G protein Signaling-21 (RGS21).
  2. RGS21 protein a regulator of taste and mucociliary clearance.
    Title: RGS21, a regulator of taste and mucociliary clearance?
  3. RGS21 modulates bitter taste signal transduction.
    Title: Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in sensory perception of bitter taste IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of sweet taste IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of umami taste IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmission of nerve impulse IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
regulator of G-protein signaling 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290269.2 → NP_001277198.1  regulator of G-protein signaling 21 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC158950
    Consensus CDS
    CCDS69952.1
    UniProtKB/TrEMBL
    V9GXQ3
    Related
    ENSMUSP00000139265.2, ENSMUST00000184189.3
    Conserved Domains (1) summary
    cl02565
    Location:25 → 135
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  2. NM_001421024.1 → NP_001407953.1  regulator of G-protein signaling 21 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158950
    UniProtKB/TrEMBL
    A0A5S9EHU3

  3. NM_001421025.1 → NP_001407954.1  regulator of G-protein signaling 21 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158950
    UniProtKB/TrEMBL
    A0A5S9EHU9

RNA

  1. NR_110891.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158950

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    144392388..144443185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152654.1 → XP_036008547.1  regulator of G-protein signaling 21 isoform X3

    UniProtKB/TrEMBL
    A0A5S9EHU9
    Conserved Domains (1) summary
    cl02565
    Location:4 → 114
    RGS; Regulator of G protein signaling (RGS) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version

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