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H3f3c H3 histone, family 3C [ Mus musculus (house mouse) ]

Gene ID: 625328, updated on 27-Nov-2024

Summary

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Official Symbol
H3f3cprovided by MGI
Official Full Name
H3 histone, family 3Cprovided by MGI
Primary source
MGI:MGI:3650546
See related
AllianceGenome:MGI:3650546
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H3-5; H3mm11; Gm14384
Summary
Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Predicted to be involved in nucleosome assembly. Predicted to be located in nucleoplasm. Predicted to be part of nucleosome. Predicted to be active in nucleus. Orthologous to human H3C14 (H3 clustered histone 14). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See H3f3c in Genome Data Viewer
Location:
2 E5; 2 59.97 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (119495597..119496633, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (119665116..119666152, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene nucleolar and spindle associated protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E3395 Neighboring gene nuclear encoded rRNA 5S 204 Neighboring gene STARR-positive B cell enhancer ABC_E9201 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 1 Neighboring gene RTF1, Paf1/RNA polymerase II complex component Neighboring gene STARR-positive B cell enhancer ABC_E7852 Neighboring gene STARR-seq mESC enhancer starr_05489 Neighboring gene predicted gene, 25857

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Short sequences can efficiently recruit histone H3 lysine 27 trimethylation in the absence of enhancer activity and DNA methylation. Jermann P, et al. Proc Natl Acad Sci U S A, 2014 Aug 19. PMID 25092339, Free PMC Article
  2. Heterochromatin formation in the mouse embryo requires critical residues of the histone variant H3.3. Santenard A, et al. Nat Cell Biol, 2010 Sep. PMID 20676102, Free PMC Article
  3. Histone variant H3.3 orchestrates neural stem cell differentiation in the developing brain. Xia W, et al. Cell Death Differ, 2017 Sep. PMID 28524856, Free PMC Article
  4. The role of histone chaperones in osteoblastic differentiation of C2C12 myoblasts. Song TY, et al. Biochem Biophys Res Commun, 2012 Jul 13. PMID 22705305
  5. Every amino acid matters: essential contributions of histone variants to mammalian development and disease. Maze I, et al. Nat Rev Genet, 2014 Apr. PMID 24614311, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nucleosome assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
  
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
histone H3.3C
Names
embryonic

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370931.1 → NP_001357860.1  histone H3.3C

    Status: VALIDATED

    Source sequence(s)
    AL844536
    UniProtKB/Swiss-Prot
    P02301
    UniProtKB/TrEMBL
    A1L0U3, A1L0V4
    Conserved Domains (1) summary
    PTZ00018
    Location:1 → 136
    PTZ00018; histone H3; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    119495597..119496633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02301.3 GenPept UniProtKB/Swiss-Prot:P02301

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials