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Catspere1 cation channel sperm associated auxiliary subunit epsilon 1 [ Mus musculus (house mouse) ]

Gene ID: 631584, updated on 9-Dec-2024

Summary

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Official Symbol
Catspere1provided by MGI
Official Full Name
cation channel sperm associated auxiliary subunit epsilon 1provided by MGI
Primary source
MGI:MGI:3647531
See related
Ensembl:ENSMUSG00000102483 AllianceGenome:MGI:3647531
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm7068; Catspere; EG631584
Summary
Predicted to be involved in flagellated sperm motility and sperm capacitation. Located in sperm principal piece. Part of CatSper complex. Orthologous to human CATSPERE (catsper channel auxiliary subunit epsilon). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward testis adult (RPKM 11.9) See more
Orthologs
human all
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Genomic context

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See Catspere1 in Genome Data Viewer
Location:
1 H4; 1 82.82 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (177635985..177789819)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (177808419..177962253)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30115 Neighboring gene STARR-seq mESC enhancer starr_03132 Neighboring gene sperm microtubule inner protein 3 Neighboring gene STARR-seq mESC enhancer starr_03133 Neighboring gene STARR-positive B cell enhancer ABC_E4395 Neighboring gene STARR-positive B cell enhancer ABC_E632 Neighboring gene STARR-seq mESC enhancer starr_03135 Neighboring gene adenylosuccinate synthase 2 Neighboring gene ribosomal protein S8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_03137 Neighboring gene STARR-positive B cell enhancer ABC_E2589 Neighboring gene cation channel sperm associated auxiliary subunit epsilon 2 Neighboring gene predicted gene, 25312 Neighboring gene STARR-seq mESC enhancer starr_03139 Neighboring gene translin-associated factor X pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CatSperζ regulates the structural continuity of sperm Ca(2+) signaling domains and is required for normal fertility. Chung JJ, et al. Elife, 2017 Feb 23. PMID 28226241, Free PMC Article
  2. Structure of a mammalian sperm cation channel complex. Lin S, et al. Nature, 2021 Jul. PMID 34225353
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in flagellated sperm motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sperm capacitation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of CatSper complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CatSper complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in sperm principal piece IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm principal piece IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm principal piece ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cation channel sperm-associated auxiliary subunit epsilon
Names
C1orf101-like protein
catSper-epsilon
catSperepsilon
cation channel sperm-associated protein subunit epsilon

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368823.1 → NP_001355752.1  cation channel sperm-associated auxiliary subunit epsilon precursor

    Status: VALIDATED

    Source sequence(s)
    AC157787, AC163217
    Consensus CDS
    CCDS87930.1
    UniProtKB/Swiss-Prot
    P0DP43
    UniProtKB/TrEMBL
    A0A5F8MPP5
    Related
    ENSMUSP00000159061.2, ENSMUST00000194528.3
    Conserved Domains (1) summary
    pfam15020
    Location:694 → 931
    CATSPERD; Cation channel sperm-associated protein subunit delta

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    177635985..177789819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314031.2 → XP_017169520.1  cation channel sperm-associated auxiliary subunit epsilon isoform X2

    UniProtKB/Swiss-Prot
    P0DP43
    Conserved Domains (1) summary
    pfam15020
    Location:652 → 889
    CATSPERD; Cation channel sperm-associated protein subunit delta

  2. XM_006497084.3 → XP_006497147.1  cation channel sperm-associated auxiliary subunit epsilon isoform X1

    UniProtKB/Swiss-Prot
    P0DP43
    Conserved Domains (1) summary
    pfam15020
    Location:723 → 917
    CATSPERD; Cation channel sperm-associated protein subunit delta

  3. XM_006497087.1 → XP_006497150.1  cation channel sperm-associated auxiliary subunit epsilon isoform X5

  4. XM_030241928.1 → XP_030097788.1  cation channel sperm-associated auxiliary subunit epsilon isoform X6

  5. XM_030241929.1 → XP_030097789.1  cation channel sperm-associated auxiliary subunit epsilon isoform X7

    UniProtKB/TrEMBL
    A0A5F8MPD0

  6. XM_017314033.1 → XP_017169522.1  cation channel sperm-associated auxiliary subunit epsilon isoform X4

    Conserved Domains (1) summary
    pfam15020
    Location:508 → 745
    CATSPERD; Cation channel sperm-associated protein subunit delta

  7. XM_006497085.2 → XP_006497148.1  cation channel sperm-associated auxiliary subunit epsilon isoform X3

    UniProtKB/Swiss-Prot
    P0DP43
    Conserved Domains (1) summary
    pfam15020
    Location:543 → 780
    CATSPERD; Cation channel sperm-associated protein subunit delta

RNA

  1. XR_001779559.1 RNA Sequence

  2. XR_001779564.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DP43.1 GenPept UniProtKB/Swiss-Prot:P0DP43

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