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Btnl4 butyrophilin-like 4 [ Mus musculus (house mouse) ]

Gene ID: 632126, updated on 4-Jan-2025

Summary

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Official Symbol
Btnl4provided by MGI
Official Full Name
butyrophilin-like 4provided by MGI
Primary source
MGI:MGI:1932036
See related
Ensembl:ENSMUSG00000058435 AllianceGenome:MGI:1932036
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NG11; Btn3a3; EG632126
Summary
Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in large intestine adult (RPKM 30.7), small intestine adult (RPKM 15.5) and 3 other tissues See more
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Genomic context

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See Btnl4 in Genome Data Viewer
Location:
17 B1; 17 18.06 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34687320..34696402, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34468410..34477428, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34535059-34535242 Neighboring gene STARR-positive B cell enhancer ABC_E4211 Neighboring gene non-histone chromosomal protein HMG-14-like Neighboring gene testis expressed basic protein 1 Neighboring gene butyrophilin-like 5, pseudogene Neighboring gene predicted gene 15331

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments. Di Marco Barros R, et al. Cell, 2016 Sep 22. PMID 27641500, Free PMC Article
  2. Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial γδ T cell compartments. Jandke A, et al. Nat Commun, 2020 Jul 28. PMID 32724083, Free PMC Article
  3. BTL-II: a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse. Stammers M, et al. Immunogenetics, 2000 Apr. PMID 10803852
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC54828

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
butyrophilin-like 4
Names
butyrophilin, subfamily 3, member A3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030746.2 → NP_109671.1  butyrophilin-like 4 precursor

    See identical proteins and their annotated locations for NP_109671.1

    Status: VALIDATED

    Source sequence(s)
    CT009767
    Consensus CDS
    CCDS50077.1
    UniProtKB/TrEMBL
    A2CG29
    Related
    ENSMUSP00000064161.5, ENSMUST00000065841.5
    Conserved Domains (2) summary
    cd13733
    Location:344 → 497
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
    cl11960
    Location:45 → 145
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34687320..34696402 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249964.2 → XP_030105824.1  butyrophilin-like 4 isoform X3

    Conserved Domains (1) summary
    cl11960
    Location:45 → 145
    Ig; Immunoglobulin domain

  2. XM_030249962.1 → XP_030105822.1  butyrophilin-like 4 isoform X2

    Conserved Domains (1) summary
    cl11960
    Location:45 → 145
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

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