CXCL5 C-X-C motif chemokine ligand 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CXCL5provided by HGNC
Official Full Name: C-X-C motif chemokine ligand 5provided by HGNC
Primary source: HGNC:HGNC:10642
See related: Ensembl:ENSG00000163735 MIM:600324; AllianceGenome:HGNC:10642
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SCYB5; ENA-78
Summary: This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression: Biased expression in appendix (RPKM 23.4), urinary bladder (RPKM 8.7) and 5 other tissues See more
Orthologs: all
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Genomic context

Location:: 4q13.3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (73995642..73998677, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (77339277..77342312, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (74861359..74864394, complement)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CXCL5 impedes CD8[+] T cell immunity by upregulating PD-L1 expression in lung cancer via PXN/AKT signaling phosphorylation and neutrophil chemotaxis.
Title: CXCL5 impedes CD8(+) T cell immunity by upregulating PD-L1 expression in lung cancer via PXN/AKT signaling phosphorylation and neutrophil chemotaxis.
A2AR-mediated CXCL5 upregulation on macrophages promotes NSCLC progression via NETosis.
Title: A2AR-mediated CXCL5 upregulation on macrophages promotes NSCLC progression via NETosis.
CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint pain and inflammation in experimental gouty arthritis.
Title: CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint pain and inflammation in experimental gouty arthritis.
Serum levels of CXCL5 are decreased and correlate with circulating platelet counts in systemic lupus erythematosus.
Title: Serum levels of CXCL5 are decreased and correlate with circulating platelet counts in systemic lupus erythematosus.
Prognostic marker CXCL5 in glioblastoma polyformis and its mechanism of immune invasion.
Title: Prognostic marker CXCL5 in glioblastoma polyformis and its mechanism of immune invasion.
CircNRIP1 promotes proliferation, migration and phenotypic switch of Ang II-induced HA-VSMCs by increasing CXCL5 mRNA stability via recruiting IGF2BP1.
Title: CircNRIP1 promotes proliferation, migration and phenotypic switch of Ang II-induced HA-VSMCs by increasing CXCL5 mRNA stability via recruiting IGF2BP1.
CXCL5 and CXCL14, but not CXCL16 as potential biomarkers of colorectal cancer.
Title: CXCL5 and CXCL14, but not CXCL16 as potential biomarkers of colorectal cancer.
DIA-based analysis of the menstrual blood proteome identifies association between CXCL5 and IL1RN and endometriosis.
Title: DIA-based analysis of the menstrual blood proteome identifies association between CXCL5 and IL1RN and endometriosis.
CXCL5 promotes tumorigenesis and angiogenesis of glioblastoma via JAK-STAT/NF-kappab signaling pathways.
Title: CXCL5 promotes tumorigenesis and angiogenesis of glioblastoma via JAK-STAT/NF-κb signaling pathways.
Mechanistic role of CXCL5 in cardiovascular disease, diabetes mellitus, and kidney disease.
Title: Mechanistic role of CXCL5 in cardiovascular disease, diabetes mellitus, and kidney disease.

Submit: New GeneRIF Correction See all GeneRIFs (133)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope transmembrane glycoprotein gp41	env	A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of chemokine (C-X-C motif) ligand 5 (CXCL5) in peptide-treated PBMCs	PubMed
Tat	tat	HIV-1 Tat upregulates the expression of chemokine (C-X-C motif) ligand 5 (CXCL5) in human primary T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-67727 (e-PCR)
- UniSTS:62468

PMC201041P1 (e-PCR)
- UniSTS:271877

SHGC-67260 (e-PCR)
- UniSTS:38193

SHGC-59754 (e-PCR)
- UniSTS:49501

D4S873 (e-PCR)
- UniSTS:29534

STS-X78686 (e-PCR)
- UniSTS:47855

SHGC-67680 (e-PCR)
- UniSTS:73209

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables CXCR chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: C-X-C motif chemokine 5

Names: chemokine (C-X-C motif) ligand 5; epithelial-derived neutrophil-activating protein 78; neutrophil-activating peptide ENA-78; neutrophil-activating protein 78; small inducible cytokine subfamily B (Cys-X-Cys), member 5 (epithelial-derived neutrophil-activating peptide 78)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002994.5 → NP_002985.1 C-X-C motif chemokine 5 precursor

See identical proteins and their annotated locations for NP_002985.1

Status: REVIEWED

Source sequence(s)

AC097709

Consensus CDS

CCDS34006.1

UniProtKB/Swiss-Prot

P42830, Q96QE1

UniProtKB/TrEMBL

Q6I9S7

Related

ENSP00000296027.4, ENST00000296027.5

Conserved Domains (1) summary

cd00273
Location:46 → 107

Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...