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Ube4b ubiquitination factor E4B [ Mus musculus (house mouse) ]

Gene ID: 63958, updated on 27-Nov-2024

Summary

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Official Symbol
Ube4bprovided by MGI
Official Full Name
ubiquitination factor E4Bprovided by MGI
Primary source
MGI:MGI:1927086
See related
Ensembl:ENSMUSG00000028960 AllianceGenome:MGI:1927086
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UFD2; UFD2a; Ufd2p; mKIAA0684; D4Bwg0973e; 4930551I19Rik; 4933406G05Rik
Summary
Enables ATP binding activity; enzyme binding activity; and ubiquitin-ubiquitin ligase activity. Acts upstream of or within several processes, including protein ubiquitination; ubiquitin-dependent protein catabolic process; and ventricular trabecula myocardium morphogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human UBE4B (ubiquitination factor E4B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 14.6), cerebellum adult (RPKM 13.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ube4b in Genome Data Viewer
Location:
4 E2; 4 79.08 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (149412873..149512618, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (149328416..149428161, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12104 Neighboring gene STARR-positive B cell enhancer ABC_E3554 Neighboring gene phosphogluconate dehydrogenase Neighboring gene kinesin family member 1B Neighboring gene STARR-positive B cell enhancer ABC_E845 Neighboring gene ubiquitination factor E4B, opposite strand 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:148775428-148775611 Neighboring gene STARR-positive B cell enhancer ABC_E8033 Neighboring gene STARR-seq mESC enhancer starr_12112 Neighboring gene STARR-seq mESC enhancer starr_12113 Neighboring gene STARR-seq mESC enhancer starr_12114 Neighboring gene tRNA methyltransferase 11-2, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_12115 Neighboring gene retinol binding protein 7, cellular Neighboring gene nicotinamide nucleotide adenylyltransferase 1 Neighboring gene transmembrame protein 274

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Increased E4 activity in mice leads to ubiquitin-containing aggregates and degeneration of hypothalamic neurons resulting in obesity. Susaki E, et al. J Biol Chem, 2010 May 14. PMID 20190229, Free PMC Article
  2. Downregulation of UBE4B promotes CNS axon regrowth and functional recovery after stroke. Jin S, et al. iScience, 2023 Jan 20. PMID 36654858, Free PMC Article
  3. Non-nuclear Wld(S) determines its neuroprotective efficacy for axons and synapses in vivo. Beirowski B, et al. J Neurosci, 2009 Jan 21. PMID 19158292, Free PMC Article
  4. A Ufd2/D4Cole1e chimeric protein and overexpression of Rbp7 in the slow Wallerian degeneration (WldS) mouse. Conforti L, et al. Proc Natl Acad Sci U S A, 2000 Oct 10. PMID 11027338, Free PMC Article
  5. The gene for slow Wallerian degeneration (Wld(s)) is also protective against vincristine neuropathy. Wang M, et al. Neurobiol Dis, 2001 Feb. PMID 11162249

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development.
    Title: Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development.
  2. The regulated expression of these UFD2a isoforms most likely imparts divergent functions that are important for myogenesis.
    Title: A novel conserved isoform of the ubiquitin ligase UFD2a/UBE4B is expressed exclusively in mature striated muscle cells.
  3. Characterization of the UFD2a gene.
    Title: Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a.
  4. UFD2a is essential for the development of cardiac muscle, as well as for the protection of spinocerebellar neurons from degeneration induced by endoplasmic reticulum stress.
    Title: Mammalian E4 is required for cardiac development and maintenance of the nervous system.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity TAS
Traceable Author Statement
more info
 PubMed 
enables ubiquitin-ubiquitin ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-ubiquitin ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables unfolded protein binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in granzyme-mediated apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in granzyme-mediated apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within protein autoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within protein monoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein polyubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to UV ISO
Inferred from Sequence Orthology
more info
  
involved_in response to UV ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within ventricular trabecula myocardium morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ubiquitin ligase complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin conjugation factor E4 B
Names
RING-type E3 ubiquitin transferase E4 B
ubiquitin fusion degradation protein 2
ubiquitination factor E4B, UFD2 homolog
NP_001391797.1
NP_001391798.1
NP_071305.2
XP_006539151.1
XP_036020184.1
XP_036020185.1
XP_036020187.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001404868.1 → NP_001391797.1  ubiquitin conjugation factor E4 B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606973

  2. NM_001404869.1 → NP_001391798.1  ubiquitin conjugation factor E4 B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL606973
    Related
    ENSMUSP00000158872.2, ENSMUST00000239095.2

  3. NM_022022.4 → NP_071305.2  ubiquitin conjugation factor E4 B isoform 1

    See identical proteins and their annotated locations for NP_071305.2

    Status: VALIDATED

    Source sequence(s)
    AL606973
    Consensus CDS
    CCDS18958.1
    UniProtKB/Swiss-Prot
    Q6DID4, Q9EQE0, Q9ES00
    UniProtKB/TrEMBL
    Q6NWW1
    Related
    ENSMUSP00000099501.4, ENSMUST00000103212.10
    Conserved Domains (2) summary
    pfam04564
    Location:1099 → 1169
    U-box; U-box domain
    pfam10408
    Location:462 → 1082
    Ufd2P_core; Ubiquitin elongating factor core

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    149412873..149512618 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539088.4 → XP_006539151.1  ubiquitin conjugation factor E4 B isoform X4

    UniProtKB/TrEMBL
    A0A571BD95
    Conserved Domains (3) summary
    PHA03307
    Location:275 → 522
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16658
    Location:1341 → 1415
    RING-Ubox_UBE4B; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 B (UBE4B) and similar proteins
    pfam10408
    Location:708 → 1328
    Ufd2P_core; Ubiquitin elongating factor core

  2. XM_036164292.1 → XP_036020185.1  ubiquitin conjugation factor E4 B isoform X3

    UniProtKB/TrEMBL
    A0A571BD95
    Conserved Domains (3) summary
    PHA03307
    Location:275 → 522
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16658
    Location:1341 → 1399
    RING-Ubox_UBE4B; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 B (UBE4B) and similar proteins
    pfam10408
    Location:708 → 1328
    Ufd2P_core; Ubiquitin elongating factor core

  3. XM_036164291.1 → XP_036020184.1  ubiquitin conjugation factor E4 B isoform X2

    UniProtKB/TrEMBL
    A0A5F8MP95
    Conserved Domains (3) summary
    PHA03247
    Location:289 → 514
    PHA03247; large tegument protein UL36; Provisional
    cd16658
    Location:1380 → 1454
    RING-Ubox_UBE4B; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 B (UBE4B) and similar proteins
    pfam10408
    Location:747 → 1367
    Ufd2P_core; Ubiquitin elongating factor core

  4. XM_036164294.1 → XP_036020187.1  ubiquitin conjugation factor E4 B isoform X6

    Conserved Domains (2) summary
    cd16658
    Location:898 → 956
    RING-Ubox_UBE4B; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 B (UBE4B) and similar proteins
    pfam10408
    Location:265 → 885
    Ufd2P_core; Ubiquitin elongating factor core
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ES00.3 GenPept UniProtKB/Swiss-Prot:Q9ES00

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