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Gmfg glia maturation factor, gamma [ Mus musculus (house mouse) ]

Gene ID: 63986, updated on 27-Nov-2024

Summary

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Official Symbol
Gmfgprovided by MGI
Official Full Name
glia maturation factor, gammaprovided by MGI
Primary source
MGI:MGI:1927135
See related
Ensembl:ENSMUSG00000060791 AllianceGenome:MGI:1927135
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610039G16Rik; 2310057N07Rik
Summary
Predicted to enable Arp2/3 complex binding activity. Acts upstream of or within actin filament debranching and negative regulation of Arp2/3 complex-mediated actin nucleation. Predicted to be active in cortical actin cytoskeleton. Is expressed in several structures, including brain; cardiovascular system; gut; hemolymphoid system; and yolk sac. Orthologous to human GMFG (glia maturation factor gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in thymus adult (RPKM 15.0), liver E18 (RPKM 6.0) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Gmfg in Genome Data Viewer
Location:
7 A3; 7 16.76 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28136894..28147655)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28437469..28448230)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Paf1, RNA polymerase II complex component Neighboring gene STARR-positive B cell enhancer ABC_E289 Neighboring gene mediator complex subunit 29 Neighboring gene sterile alpha motif domain containing 4B Neighboring gene STARR-positive B cell enhancer ABC_E240 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29225831-29226014 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29231461-29231644 Neighboring gene STARR-seq mESC enhancer starr_18417 Neighboring gene leucine rich repeat and fibronectin type III domain containing 1 Neighboring gene predicted gene 6518

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Glia maturation factor-γ regulates murine macrophage iron metabolism and M2 polarization through mitochondrial ROS. Aerbajinai W, et al. Blood Adv, 2019 Apr 23. PMID 30971398, Free PMC Article
  2. Glia maturation factor-gamma is preferentially expressed in microvascular endothelial and inflammatory cells and modulates actin cytoskeleton reorganization. Ikeda K, et al. Circ Res, 2006 Aug 18. PMID 16873721
  3. Glia maturation factor-γ is involved in S1P-induced marginal zone B-cell chemotaxis and optimal IgM production to type II T-independent antigen. Li Y, et al. Int Immunol, 2022 Jan 1. PMID 34673932
  4. Identification and isolation of a full-length clone of mouse GMFB (Gmfb), a putative intracellular kinase regulator, differentially expressed in telencephalon. Bourgeois F, et al. Cytogenet Cell Genet, 2001. PMID 11435704
  5. Analysis of the interactions between GMF and Arp2/3 complex in two binding sites by molecular dynamics simulation. Popinako A, et al. Biochem Biophys Res Commun, 2018 Feb 5. PMID 29339159

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glia maturation factor-gamma is involved in S1P-induced marginal zone B-cell chemotaxis and optimal IgM production to type II T-independent antigen.
    Title: Glia maturation factor-γ is involved in S1P-induced marginal zone B-cell chemotaxis and optimal IgM production to type II T-independent antigen.
  2. findings suggest that GMFG is an important regulator in cellular iron metabolism and macrophage phenotype and could be a novel therapeutic target for modulating macrophage function in immune and metabolic disorders.
    Title: Glia maturation factor-γ regulates murine macrophage iron metabolism and M2 polarization through mitochondrial ROS.
  3. Gmfg has two separate binding sites on Arp2/3 complex with high (site 1) and low (site 2) affinity. X-ray crystallography revealed closely located positions of Gmfg in site 1. Molecular dynamics simulation allowed determining the binding pocket for Gmfg in site 2.
    Title: Analysis of the interactions between GMF and Arp2/3 complex in two binding sites by molecular dynamics simulation.
  4. GMF debranches filaments by a mechanism related to cofilin-mediated severing, but in which GMF has evolved to target molecular junctions between actin-related proteins in the Arp2/3 complex and actin subunits in the daughter filament of the branch.
    Title: GMF severs actin-Arp2/3 complex branch junctions by a cofilin-like mechanism.
  5. The GMF-Arp2 interface reveals how the ADF-H actin-binding domain in GMF is exploited to specifically recognize Arp2/3 complex and not actin.
    Title: Structural basis for regulation of Arp2/3 complex by GMF.
  6. GMFG is a novel factor in actin cytoskeleton reorganization and is expressed preferentially in microvascular endothelial and inflammatory cells in embryonic development.
    Title: Glia maturation factor-gamma is preferentially expressed in microvascular endothelial and inflammatory cells and modulates actin cytoskeleton reorganization.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Arp2/3 complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Arp2/3 complex binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament debranching IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within actin filament debranching IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glia maturation factor gamma
Names
GMF-gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039192.2 → NP_001034281.1  glia maturation factor gamma isoform a

    See identical proteins and their annotated locations for NP_001034281.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate first exon compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC149606, AK009967
    Consensus CDS
    CCDS39860.1
    UniProtKB/Swiss-Prot
    Q9ERL7
    UniProtKB/TrEMBL
    A7VJA4
    Related
    ENSMUSP00000077889.7, ENSMUST00000078845.13
    Conserved Domains (1) summary
    cd11283
    Location:9 → 130
    ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins

  2. NM_001290550.2 → NP_001277479.1  glia maturation factor gamma isoform b

    See identical proteins and their annotated locations for NP_001277479.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon and initiates translation at an alternate start codon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC149606, BE629139
    Consensus CDS
    CCDS80687.1
    UniProtKB/TrEMBL
    D3YY16
    Related
    ENSMUSP00000103924.2, ENSMUST00000108289.8
    Conserved Domains (1) summary
    cd11283
    Location:2 → 89
    ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins

  3. NM_001377092.1 → NP_001364021.1  glia maturation factor gamma isoform c

    Status: VALIDATED

    Source sequence(s)
    AC149606
    Conserved Domains (1) summary
    cd11283
    Location:1 → 97
    ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins

  4. NM_022024.3 → NP_071307.1  glia maturation factor gamma isoform a

    See identical proteins and their annotated locations for NP_071307.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC149606, AK002834
    Consensus CDS
    CCDS39859.1
    UniProtKB/Swiss-Prot
    Q9ERL7
    UniProtKB/TrEMBL
    A7VJA4
    Related
    ENSMUSP00000103927.3, ENSMUST00000108292.9
    Conserved Domains (1) summary
    cd11283
    Location:9 → 130
    ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    28136894..28147655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540273.4 → XP_006540336.1  glia maturation factor gamma isoform X1

    See identical proteins and their annotated locations for XP_006540336.1

    UniProtKB/TrEMBL
    D3YY16
    Conserved Domains (1) summary
    cd11283
    Location:2 → 89
    ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ERL7.1 GenPept UniProtKB/Swiss-Prot:Q9ERL7

Gene LinkOut

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