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Yeats4 YEATS domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 64050, updated on 27-Nov-2024

Summary

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Official Symbol
Yeats4provided by MGI
Official Full Name
YEATS domain containing 4provided by MGI
Primary source
MGI:MGI:1927224
See related
Ensembl:ENSMUSG00000020171 AllianceGenome:MGI:1927224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GAS41; NuBI-1; 4930573H17Rik; B230215M10Rik
Summary
Predicted to enable lysine-acetylated histone binding activity. Predicted to be involved in chromatin remodeling; regulation of cell cycle; and regulation of nucleobase-containing compound metabolic process. Located in nucleoplasm. Is expressed in genitourinary system; sensory organ; tooth; and trunk somite. Orthologous to human YEATS4 (YEATS domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 52.0), whole brain E14.5 (RPKM 41.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Yeats4 in Genome Data Viewer
Location:
10 D2; 10 65.26 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (117051046..117060412, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (117215141..117224507, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53635 Neighboring gene RIKEN cDNA 4930423D24 gene Neighboring gene predicted gene, 40769 Neighboring gene STARR-positive B cell enhancer ABC_E3918 Neighboring gene STARR-positive B cell enhancer ABC_E8367 Neighboring gene STARR-positive B cell enhancer ABC_E9353 Neighboring gene lysozyme 3 Neighboring gene lysozyme 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription. Liu B, et al. J Exp Med, 2019 Nov 4. PMID 31434684, Free PMC Article
  2. Anomalous incisor morphology indicates tissue-specific roles for Tfap2a and Tfap2b in tooth development. Woodruff ED, et al. Dev Biol, 2021 Apr. PMID 33460639, Free PMC Article
  3. Expression, cellular distribution and protein binding of the glioma amplified sequence (GAS41), a highly conserved putative transcription factor. Munnia A, et al. Oncogene, 2001 Aug 9. PMID 11521196
  4. GAS41, a highly conserved protein in eukaryotic nuclei, binds to NuMA. Harborth J, et al. J Biol Chem, 2000 Oct 13. PMID 10913114
  5. Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes. Ruhl DD, et al. Biochemistry, 2006 May 2. PMID 16634648

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysine-acetylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables lysine-acetylated histone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables modification-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of apoptotic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of double-strand break repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NuA4 histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of NuA4 histone acetyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
  
part_of nucleosome NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
YEATS domain-containing protein 4
Names
glioma-amplified sequence 41 homolog
glioma-amplified sequence-41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026570.4 → NP_080846.1  YEATS domain-containing protein 4

    See identical proteins and their annotated locations for NP_080846.1

    Status: VALIDATED

    Source sequence(s)
    AK010522, CJ213771
    Consensus CDS
    CCDS24191.1
    UniProtKB/Swiss-Prot
    Q9CR11, Q9CW86
    Related
    ENSMUSP00000020382.7, ENSMUST00000020382.8
    Conserved Domains (1) summary
    cd16909
    Location:19 → 155
    YEATS_GAS41_like; YEATS domain found in YEATS domain-containing protein 4 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    117051046..117060412 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CR11.1 GenPept UniProtKB/Swiss-Prot:Q9CR11

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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