NRON non-coding repressor of NFAT [Homo sapiens (human)] - Gene

Summary

Official Symbol: NRONprovided by HGNC
Official Full Name: non-coding repressor of NFATprovided by HGNC
Primary source: HGNC:HGNC:37079
See related: MIM:609618; AllianceGenome:HGNC:37079
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NCRNA00194
Summary: Predicted to act upstream of or within negative regulation of dephosphorylation; regulation of calcineurin-NFAT signaling cascade; and regulation of cytokine production. Predicted to be part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: mouse all
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Genomic context

Location:: 9q33.3; 9

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (126407775..126410504, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (138613545..138616268, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (129170054..129172783, complement)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA NRON negatively regulates cisplatin-induced cell apoptosis via downregulating miR-31 in esophageal squamous cell carcinomas.
Title: LncRNA NRON negatively regulates cisplatin-induced cell apoptosis via downregulating miR-31 in esophageal squamous cell carcinomas.
Increased Expression of the lncRNA NRON Along With NFATc1/PIM-1 in Labial Salivary Glands of Sjogren's Syndrome Patients.
Title: Increased Expression of the lncRNA NRON Along With NFATc1/PIM-1 in Labial Salivary Glands of Sjögren's Syndrome Patients.
LncRNA snaR was up-regulated in triple-negative breast cancer tissues and was inversely correlated with NRON. . NRON overexpression inhibited cancer cell proliferation and down-regulated snaR. The snaR overexpression reduced the effects of NRON overexpression.
Title: LncRNA NRON down-regulates lncRNA snaR and inhibits cancer cell proliferation in TNBC.
expression of an age-accumulated lncRNA (NRON) was decreased, whereas that of its immunity-related target gene (NFAT) was increased, in both CD28(null)CD8(+) T cells and CMVpp65CD8(+) T cells of elderly individuals with persistent cytomegalovirus infection
Title: Reduced expression of the lncRNA NRON is a potential hallmark of the CMV-amplified CD8+ T cell accumulations commonly seen in older humans.
data indicated that NRON alleviates atrial fibrosis via promoting NFATc3 phosphorylation.
Title: LncRNA NRON alleviates atrial fibrosis via promoting NFATc3 phosphorylation.
LncNRON may function as a new HCC prognostic marker.
Title: Long non-coding RNA NRON is downregulated in HCC and suppresses tumour cell proliferation and metastasis.
NRON Long noncoding RNA potently suppresses the viral transcription by decreasing the cellular abundance of viral transactivator protein Tat.
Title: Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradation.
elevation of circulating NRON and MHRT predicts heart failure (HF) and may be considered as novel biomarkers of HF.
Title: Circulating long non-coding RNAs NRON and MHRT as novel predictive biomarkers of heart failure.
The effects of NRON on HIV-1 replication are shown to be mediated by NFAT, and the viral Nef and Vpu proteins to modulate NFAT activity through their effects on NRON.
Title: The lncRNA NRON modulates HIV-1 replication in a NFAT-dependent manner and is differentially regulated by early and late viral proteins.

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Phenotypes

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Variation

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Other Names

non-protein coding RNA, repressor of NFAT
noncoding repressor of NFAT

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.