Tomm40l translocase of outer mitochondrial membrane 40-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tomm40lprovided by MGI
Official Full Name: translocase of outer mitochondrial membrane 40-likeprovided by MGI
Primary source: MGI:MGI:3589112
See related: Ensembl:ENSMUSG00000005674 AllianceGenome:MGI:3589112
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable mitochondrion targeting sequence binding activity; preprotein binding activity; and protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix. Located in mitochondrion. Orthologous to human TOMM40L (translocase of outer mitochondrial membrane 40 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver adult (RPKM 18.3), heart adult (RPKM 15.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 79.22 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (171043579..171050020, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (171217802..171222514, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI551208 (e-PCR)
- UniSTS:164138

AA209988 (e-PCR), detects polymorphism
- UniSTS:143018

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mitochondrion targeting sequence binding	IEA Inferred from Electronic Annotation more info
enables mitochondrion targeting sequence binding	ISO Inferred from Sequence Orthology more info
enables porin activity	IEA Inferred from Electronic Annotation more info
enables preprotein binding	IEA Inferred from Electronic Annotation more info
enables preprotein binding	ISO Inferred from Sequence Orthology more info
enables protein transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into mitochondrial matrix	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of mitochondrial outer membrane translocase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial outer membrane translocase complex	IEA Inferred from Electronic Annotation more info
part_of mitochondrial outer membrane translocase complex	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
part_of pore complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial import receptor subunit TOM40B

Names: translocase of outer mitochondrial membrane 40 homolog-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037170.3 → NP_001032247.1 mitochondrial import receptor subunit TOM40B

See identical proteins and their annotated locations for NP_001032247.1

Status: VALIDATED

Source sequence(s)

AC084821, AC163497

Consensus CDS

CCDS15481.1

UniProtKB/Swiss-Prot

Q9CZR3

UniProtKB/TrEMBL

D3YXS8

Related

ENSMUSP00000005817.3, ENSMUST00000005817.9

Conserved Domains (1) summary

cd07305
Location:24 → 308

Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)
NM_001412746.1 → NP_001399675.1 mitochondrial import receptor subunit TOM40B

Status: VALIDATED

Source sequence(s)

AC084821, AC163497

UniProtKB/Swiss-Prot

Q9CZR3