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KIF9 kinesin family member 9 [ Homo sapiens (human) ]

Gene ID: 64147, updated on 27-Nov-2024

Summary

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Official Symbol
KIF9provided by HGNC
Official Full Name
kinesin family member 9provided by HGNC
Primary source
HGNC:HGNC:16666
See related
Ensembl:ENSG00000088727 MIM:607910; AllianceGenome:HGNC:16666
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables identical protein binding activity. Involved in extracellular matrix disassembly; organelle disassembly; and regulation of podosome assembly. Located in microtubule; podosome; and vesicle. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis (RPKM 11.7), thyroid (RPKM 1.7) and 10 other tissues See more
Orthologs
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Genomic context

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See KIF9 in Genome Data Viewer
Location:
3p21.31
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (47227998..47282799, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (47244385..47299181, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (47269488..47324289, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr3:47082829-47083038 Neighboring gene mitochondrial ribosomal protein L57 pseudogene 3 Neighboring gene SET domain containing 2, histone lysine methyltransferase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:47108907-47109512 Neighboring gene NANOG hESC enhancer GRCh37_chr3:47125242-47125743 Neighboring gene uncharacterized LOC124906375 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:47155200-47155707 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:47155708-47156216 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14304 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14305 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14306 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19809 Neighboring gene KIF9 antisense RNA 1 Neighboring gene MPRA-validated peak4632 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:47238926-47239426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19810 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:47301362-47302268 Neighboring gene small nucleolar RNA, C/D box 13 pseudogene 3 Neighboring gene small nucleolar RNA, C/D box 13J Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:47323613-47324812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19812 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14308 Neighboring gene kelch like family member 18 Neighboring gene Sharpr-MPRA regulatory region 13740 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:47403837-47405036 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:47421897-47422574 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:47422575-47423250 Neighboring gene PTPN23 divergent transcript Neighboring gene protein tyrosine phosphatase non-receptor type 23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of bi-allelic KIF9 loss-of-function variants contributing to asthenospermia and male infertility in two Chinese families. Meng Z, et al. Front Endocrinol (Lausanne), 2022. PMID 36686457, Free PMC Article
  2. The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9. Piddini E, et al. EMBO J, 2001 Aug 1. PMID 11483511, Free PMC Article
  3. The GTPase Gem and its partner Kif9 are required for chromosome alignment, spindle length control, and mitotic progression. Andrieu G, et al. FASEB J, 2012 Dec. PMID 22964304
  4. The kinesin KIF9 and reggie/flotillin proteins regulate matrix degradation by macrophage podosomes. Cornfine S, et al. Mol Biol Cell, 2011 Jan 15. PMID 21119006, Free PMC Article
  5. Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies. Armstrong LA, et al. PLoS One, 2021. PMID 34270554, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of bi-allelic KIF9 loss-of-function variants contributing to asthenospermia and male infertility in two Chinese families.
    Title: Identification of bi-allelic KIF9 loss-of-function variants contributing to asthenospermia and male infertility in two Chinese families.
  2. Data show a mechanism by which GTPase Gem contributes to the mitotic progression by maintaining correct spindle length through the kinesin Kif9.
    Title: The GTPase Gem and its partner Kif9 are required for chromosome alignment, spindle length control, and mitotic progression.
  3. kinesin KIF9 and reggie/flotillin proteins are novel regulators of macrophage podosomes and their interaction is critical for podosomal matrix-degradation
    Title: The kinesin KIF9 and reggie/flotillin proteins regulate matrix degradation by macrophage podosomes.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC104186

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in organelle disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of podosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in podosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kinesin-like protein KIF9
Names
kinesin protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134878.3 → NP_001128350.1  kinesin-like protein KIF9 isoform 2

    See identical proteins and their annotated locations for NP_001128350.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and includes an alternate in-frame exon in the mid coding region, compared to variant 1. The encoded isoform (2) is longer than isoform 1. Both variants 2 and 4 encode the same isoform.
    Source sequence(s)
    AC104447, AI741745, AK292547, AK314418
    Consensus CDS
    CCDS2752.1
    UniProtKB/Swiss-Prot
    Q86Z28, Q9H8A4, Q9HAQ2
    UniProtKB/TrEMBL
    A8K932
    Related
    ENSP00000391100.2, ENST00000452770.6
    Conserved Domains (2) summary
    cd01375
    Location:6 → 338
    KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
    pfam00225
    Location:12 → 340
    Kinesin; Kinesin motor domain

  2. NM_001377474.1 → NP_001364403.1  kinesin-like protein KIF9 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC104447
    UniProtKB/TrEMBL
    A8K932
    Conserved Domains (1) summary
    cl22853
    Location:6 → 263
    Motor_domain; Myosin and Kinesin motor domain

  3. NM_001377475.1 → NP_001364404.1  kinesin-like protein KIF9 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC104447
    UniProtKB/TrEMBL
    A8K932
    Conserved Domains (1) summary
    cl22853
    Location:6 → 263
    Motor_domain; Myosin and Kinesin motor domain

  4. NM_001377476.1 → NP_001364405.1  kinesin-like protein KIF9 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC104447
    Consensus CDS
    CCDS93262.1
    UniProtKB/TrEMBL
    E7EUW8, Q6PJI1
    Related
    ENSP00000391099.1, ENST00000432493.5
    Conserved Domains (1) summary
    cl22853
    Location:6 → 89
    Motor_domain; Myosin and Kinesin motor domain

  5. NM_001377477.1 → NP_001364406.1  kinesin-like protein KIF9 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC104447
    Consensus CDS
    CCDS93262.1
    UniProtKB/TrEMBL
    E7EUW8, Q6PJI1
    Related
    ENSP00000406815.1, ENST00000425853.5
    Conserved Domains (1) summary
    cl22853
    Location:6 → 89
    Motor_domain; Myosin and Kinesin motor domain

  6. NM_001413975.1 → NP_001400904.1  kinesin-like protein KIF9 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC104447

  7. NM_001413976.1 → NP_001400905.1  kinesin-like protein KIF9 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC104447

  8. NM_022342.6 → NP_071737.1  kinesin-like protein KIF9 isoform 1

    See identical proteins and their annotated locations for NP_071737.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (1).
    Source sequence(s)
    AC104447, AF311212, AI741745, AK292547
    Consensus CDS
    CCDS2751.1
    UniProtKB/TrEMBL
    A8K932
    Related
    ENSP00000414987.2, ENST00000444589.6
    Conserved Domains (2) summary
    cd01375
    Location:6 → 338
    KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
    pfam00225
    Location:12 → 340
    Kinesin; Kinesin motor domain

  9. NM_182902.4 → NP_878905.2  kinesin-like protein KIF9 isoform 2

    See identical proteins and their annotated locations for NP_878905.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate in-frame exon in the mid coding region, compared to variant 1, and encodes an isoform (2) that is longer than isoform 1. Both variants 2 and 4 encode the same isoform.
    Source sequence(s)
    AC104447, AI741745, AK292547, AK314418, BC030657
    Consensus CDS
    CCDS2752.1
    UniProtKB/Swiss-Prot
    Q86Z28, Q9H8A4, Q9HAQ2
    UniProtKB/TrEMBL
    A8K932
    Related
    ENSP00000507186.1, ENST00000684063.1
    Conserved Domains (2) summary
    cd01375
    Location:6 → 338
    KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
    pfam00225
    Location:12 → 340
    Kinesin; Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    47227998..47282799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448712.1 → XP_047304668.1  kinesin-like protein KIF9 isoform X6

  2. XM_006713291.4 → XP_006713354.1  kinesin-like protein KIF9 isoform X4

    UniProtKB/TrEMBL
    A8K932
    Conserved Domains (2) summary
    cl22853
    Location:39 → 296
    Motor_domain; Myosin and Kinesin motor domain
    pfam00225
    Location:45 → 298
    Kinesin; Kinesin motor domain

  3. XM_005265389.5 → XP_005265446.1  kinesin-like protein KIF9 isoform X2

    UniProtKB/TrEMBL
    A8K932
    Conserved Domains (2) summary
    cd01375
    Location:39 → 371
    KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
    pfam00225
    Location:45 → 373
    Kinesin; Kinesin motor domain

  4. XM_047448709.1 → XP_047304665.1  kinesin-like protein KIF9 isoform X1

    UniProtKB/Swiss-Prot
    Q86Z28, Q9H8A4, Q9HAQ2

  5. XM_017007029.2 → XP_016862518.1  kinesin-like protein KIF9 isoform X1

    UniProtKB/Swiss-Prot
    Q86Z28, Q9H8A4, Q9HAQ2
    UniProtKB/TrEMBL
    A8K932
    Conserved Domains (2) summary
    cd01375
    Location:6 → 338
    KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
    pfam00225
    Location:12 → 340
    Kinesin; Kinesin motor domain

  6. XM_047448711.1 → XP_047304667.1  kinesin-like protein KIF9 isoform X5

  7. XM_011534007.3 → XP_011532309.1  kinesin-like protein KIF9 isoform X8

  8. XM_047448710.1 → XP_047304666.1  kinesin-like protein KIF9 isoform X3

  9. XM_047448713.1 → XP_047304669.1  kinesin-like protein KIF9 isoform X7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    47244385..47299181 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347531.1 → XP_054203506.1  kinesin-like protein KIF9 isoform X6

  2. XM_054347529.1 → XP_054203504.1  kinesin-like protein KIF9 isoform X4

  3. XM_054347527.1 → XP_054203502.1  kinesin-like protein KIF9 isoform X2

  4. XM_054347525.1 → XP_054203500.1  kinesin-like protein KIF9 isoform X1

  5. XM_054347526.1 → XP_054203501.1  kinesin-like protein KIF9 isoform X1

  6. XM_054347530.1 → XP_054203505.1  kinesin-like protein KIF9 isoform X5

  7. XM_054347533.1 → XP_054203508.1  kinesin-like protein KIF9 isoform X8

  8. XM_054347528.1 → XP_054203503.1  kinesin-like protein KIF9 isoform X3

  9. XM_054347532.1 → XP_054203507.1  kinesin-like protein KIF9 isoform X7

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_182903.2: Suppressed sequence

    Description
    NM_182903.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HAQ2.4 GenPept UniProtKB/Swiss-Prot:Q9HAQ2

Gene LinkOut

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