U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NCAPG non-SMC condensin I complex subunit G [ Homo sapiens (human) ]

Gene ID: 64151, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
NCAPGprovided by HGNC
Official Full Name
non-SMC condensin I complex subunit Gprovided by HGNC
Primary source
HGNC:HGNC:24304
See related
Ensembl:ENSG00000109805 MIM:606280; AllianceGenome:HGNC:24304
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAPG; CHCG; YCG1; NY-MEL-3
Summary
This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Expression
Broad expression in bone marrow (RPKM 7.5), lymph node (RPKM 7.1) and 21 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See NCAPG in Genome Data Viewer
Location:
4p15.31
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (17810979..17844865)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (17793327..17827212)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (17812602..17846488)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15312 Neighboring gene mediator complex subunit 28 Neighboring gene family with sequence similarity 184 member B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21355 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:17812049-17812560 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:17812561-17813073 Neighboring gene DDB1 and CUL4 associated factor 16 Neighboring gene ligand dependent nuclear receptor corepressor like Neighboring gene keratin 18 pseudogene 63 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15313 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21357 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21358 Neighboring gene uncharacterized LOC107986220

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Inhibition of NCAPG expression inactivates the Wnt/β-catenin signal to suppresses endometrial cancer cell growth in vitro. Liu C, et al. Environ Toxicol, 2021 Dec. PMID 34480403
  2. Increased expression of NCAPG (Non-SMC condensing I complex subunit G) is associated with progression and poor prognosis of lung adenocarcinoma. Wang X, et al. Bioengineered, 2022 Mar. PMID 35254214, Free PMC Article
  3. Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression. Ryu B, et al. PLoS One, 2007 Jul 4. PMID 17611626, Free PMC Article
  4. NCAPG promotes tumorigenesis of bladder cancer through NF-κB signaling pathway. Tang F, et al. Biochem Biophys Res Commun, 2022 Sep 24. PMID 35843088
  5. NCAPG is a prognostic biomarker of immune infiltration in non-small-cell lung cancer. Zhou Y, et al. Biomark Med, 2022 May. PMID 35199566

See all (121) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reduced miR-99a-3p levels in systemic lupus erythematosus may promote B cell proliferation via NCAPG and the PI3K/AKT signaling pathway.
    Title: Reduced miR-99a-3p levels in systemic lupus erythematosus may promote B cell proliferation via NCAPG and the PI3K/AKT signaling pathway.
  2. The Diagnostic and Therapeutic Value of NCAPG as a Proposed Biomarker Candidate in Acute Liver Failure.
    Title: The Diagnostic and Therapeutic Value of NCAPG as a Proposed Biomarker Candidate in Acute Liver Failure.
  3. Galectin-1-mediated high NCAPG expression correlates with poor prognosis in gastric cancer.
    Title: Galectin-1-mediated high NCAPG expression correlates with poor prognosis in gastric cancer.
  4. NCAPG as a novel prognostic biomarker in numerous cancers: a meta-analysis and bioinformatics analysis.
    Title: NCAPG as a novel prognostic biomarker in numerous cancers: a meta-analysis and bioinformatics analysis.
  5. The U2AF65/circNCAPG/RREB1 feedback loop promotes malignant phenotypes of glioma stem cells through activating the TGF-beta pathway.
    Title: The U2AF65/circNCAPG/RREB1 feedback loop promotes malignant phenotypes of glioma stem cells through activating the TGF-β pathway.
  6. The role of NCAPG in various of tumors.
    Title: The role of NCAPG in various of tumors.
  7. NCAPG Promotes Pulmonary Artery Smooth Muscle Cell Proliferation as a Promising Therapeutic Target of Idiopathic Pulmonary Hypertension: Bioinformatics Analysis and Experiment Verification.
    Title: NCAPG Promotes Pulmonary Artery Smooth Muscle Cell Proliferation as a Promising Therapeutic Target of Idiopathic Pulmonary Hypertension: Bioinformatics Analysis and Experiment Verification.
  8. Overexpression of NCAPG in ovarian cancer is associated with ovarian cancer proliferation and apoptosis via p38 MAPK signaling pathway.
    Title: Overexpression of NCAPG in ovarian cancer is associated with ovarian cancer proliferation and apoptosis via p38 MAPK signaling pathway.
  9. NCAPG promotes tumorigenesis of bladder cancer through NF-kappaB signaling pathway.
    Title: NCAPG promotes tumorigenesis of bladder cancer through NF-κB signaling pathway.
  10. NCAPG Promotes the Proliferation of Renal Clear Cell Carcinoma via Mediating with CDK1.
    Title: NCAPG Promotes the Proliferation of Renal Clear Cell Carcinoma via Mediating with CDK1.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci.
EBI GWAS Catalog
Many sequence variants affecting diversity of adult human height.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ12450, MGC126525

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic chromosome condensation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic chromosome condensation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of chromosome condensation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of chromosome separation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in condensed chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in condensed chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
  
part_of condensin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of condensin complex NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in membrane HDA PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
condensin complex subunit 3
Names
XCAP-G homolog
chromosome condensation protein G
chromosome-associated protein G
condensin subunit CAP-G
melanoma antigen NY-MEL-3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022346.5 → NP_071741.2  condensin complex subunit 3

    See identical proteins and their annotated locations for NP_071741.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
    Source sequence(s)
    AC005768, AF331796, BG398543, DB451361
    Consensus CDS
    CCDS3424.1
    UniProtKB/Swiss-Prot
    Q3MJE0, Q96SV9, Q9BPX3, Q9BUR3, Q9BVY1, Q9H914, Q9H9Z6, Q9HBI9
    UniProtKB/TrEMBL
    Q6NUR1
    Related
    ENSP00000251496.2, ENST00000251496.7
    Conserved Domains (3) summary
    pfam12719
    Location:559 → 853
    Cnd3; Nuclear condensing complex subunits, C-term domain
    pfam13646
    Location:103 → 204
    HEAT_2; HEAT repeats
    sd00044
    Location:208 → 234
    HEAT; HEAT repeat [structural motif]

RNA

  1. NR_073124.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005768, BC143383, BG398543, DB451361

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    17810979..17844865
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008543.3 → XP_016864032.1  condensin complex subunit 3 isoform X1

    UniProtKB/TrEMBL
    Q6NUR1

  2. XM_047416072.1 → XP_047272028.1  condensin complex subunit 3 isoform X2

  3. XM_047416073.1 → XP_047272029.1  condensin complex subunit 3 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    17793327..17827212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350710.1 → XP_054206685.1  condensin complex subunit 3 isoform X1

  2. XM_054350711.1 → XP_054206686.1  condensin complex subunit 3 isoform X2

  3. XM_054350712.1 → XP_054206687.1  condensin complex subunit 3 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BPX3.1 GenPept UniProtKB/Swiss-Prot:Q9BPX3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous