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syn2b synapsin IIb [ Danio rerio (zebrafish) ]

Gene ID: 641578, updated on 4-Jan-2025

Summary

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Official Symbol
syn2bprovided by ZNC
Official Full Name
synapsin IIbprovided by ZNC
Primary source
ZFIN:ZDB-GENE-051127-49
See related
Ensembl:ENSDARG00000101054 AllianceGenome:ZFIN:ZDB-GENE-051127-49
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:123199
Summary
Predicted to enable ATP binding activity. Predicted to be involved in synapse organization and synaptic vesicle clustering. Predicted to act upstream of or within neurotransmitter secretion. Predicted to be located in synaptic vesicle. Predicted to be active in synaptic vesicle membrane. Is expressed in DEL; nervous system; spinal cord neural tube; and yolk syncytial layer. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human SYN2 (synapsin II). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See syn2b in Genome Data Viewer
Location:
chromosome: 11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (674592..762721, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (648094..736223, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496662 Neighboring gene TSEN2 tRNA splicing endonuclease subunit Neighboring gene peroxisome proliferator-activated receptor gamma Neighboring gene TIMP metallopeptidase inhibitor 4, tandem duplicate 1 Neighboring gene TIMP metallopeptidase inhibitor 4, tandem duplicate 2 Neighboring gene TIMP metallopeptidase inhibitor 4, tandem duplicate 3 Neighboring gene TAM41 mitochondrial translocator assembly and maintenance homolog Neighboring gene vestigial-like family member 4b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Doublecortin in the Fish Visual System, a Specific Protein of Maturing Neurons. DeOliveira-Mello L, et al. Biology (Basel), 2022 Feb 6. PMID 35205114, Free PMC Article
  2. Identification of an endogenous substrate of zebrafish doublecortin-like protein kinase using a highly active truncation mutant. Shimomura S, et al. J Biochem, 2010 May. PMID 20097902
  3. Late recruitment of synapsin to nascent synapses is regulated by Cdk5. Easley-Neal C, et al. Cell Rep, 2013 Apr 25. PMID 23602570, Free PMC Article
  4. The expression patterns of vestigial like family member 4 genes in zebrafish embryogenesis. Xue C, et al. Gene Expr Patterns, 2018 Jun. PMID 29454044
  5. Differential expression of synapsin genes during early zebrafish development. Garbarino G, et al. Neuroscience, 2014 Nov 7. PMID 25239370

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC123199

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within neurotransmitter secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle clustering IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
synapsin-2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001327771.1 → NP_001314700.1  synapsin-2b

    Status: VALIDATED

    Source sequence(s)
    CABZ01061872, CABZ01061873, FQ311892
    UniProtKB/TrEMBL
    A0A0R4IJU5, A0A8M1P900
    Related
    ENSDARP00000133827.1, ENSDART00000166465.3
    Conserved Domains (3) summary
    pfam02078
    Location:108 → 205
    Synapsin; Synapsin, N-terminal domain
    pfam10581
    Location:1 → 27
    Synapsin_N; Synapsin N-terminal
    cl17255
    Location:207 → 409
    ATP-grasp_4; ATP-grasp domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    674592..762721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001037576.1: Suppressed sequence

    Description
    NM_001037576.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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