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COP1 COP1 E3 ubiquitin ligase [ Homo sapiens (human) ]

Gene ID: 64326, updated on 27-Nov-2024

Summary

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Official Symbol
COP1provided by HGNC
Official Full Name
COP1 E3 ubiquitin ligaseprovided by HGNC
Primary source
HGNC:HGNC:17440
See related
Ensembl:ENSG00000143207 MIM:608067; AllianceGenome:HGNC:17440
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAP78; RFWD2; CFAP78; RNF200
Summary
Enables ubiquitin protein ligase activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and response to ionizing radiation. Part of Cul4A-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 5.8), colon (RPKM 4.2) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See COP1 in Genome Data Viewer
Location:
1q25.1-q25.2
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (175944831..176207286, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (175300159..175562553, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (175913967..176176422, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2803 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:175885507-175885694 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:175892848-175893023 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:175903651-175904515 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:175905380-175906244 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:175906245-175907107 Neighboring gene ribosomal protein S29 pseudogene 5 Neighboring gene microRNA 1843 Neighboring gene small Cajal body-specific RNA 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:175976701-175977202 Neighboring gene MPRA-validated peak473 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:176065569-176066068 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1569 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2140 Neighboring gene U7 small nuclear RNA Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:176193870-176194506 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:176194507-176195142 Neighboring gene NANOG hESC enhancer GRCh37_chr1:176196158-176197147 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:176198991-176199490 Neighboring gene COP1 divergent transcript Neighboring gene ribosomal protein L13 pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. UVB-dependent changes in the expression of fast-responding early genes is modulated by huCOP1 in keratinocytes. Fazekas B, et al. J Photochem Photobiol B, 2014 Nov. PMID 25169772
  2. COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas. Dornan D, et al. Cancer Res, 2004 Oct 15. PMID 15492238
  3. Constitutively Photomorphogenic 1 Reduces the Sensitivity of Chronic Lymphocytic Leukemia Cells to Fludarabine Through Promotion of Ubiquitin-Mediated P53 Degradation. Fu C, et al. Cell Physiol Biochem, 2018. PMID 30423551
  4. RFWD2 induces cellular proliferation and selective proteasome inhibitor resistance by mediating P27 ubiquitination in multiple myeloma. Gu C, et al. Leukemia, 2021 Jun. PMID 32901100
  5. COP1 contributes to UVB-induced signaling in human keratinocytes. Kinyó A, et al. J Invest Dermatol, 2010 Feb. PMID 19741714

See all (112) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RFWD2 increases proliferation and CDDP resistance of osteosarcoma cells.
    Title: RFWD2 increases proliferation and CDDP resistance of osteosarcoma cells.
  2. STK40 inhibits trophoblast fusion by mediating COP1 ubiquitination to degrade P57[Kip2].
    Title: STK40 inhibits trophoblast fusion by mediating COP1 ubiquitination to degrade P57(Kip2).
  3. Constitutive photomorphogenic protein 1 ubiquitinates interleukin-1 receptor accessory protein in human liver cancer.
    Title: Constitutive photomorphogenic protein 1 ubiquitinates interleukin-1 receptor accessory protein in human liver cancer.
  4. Effect of COP1 in Promoting the Tumorigenesis of Gastric Cancer by Down-Regulation of CDH18 via PI3K/AKT Signal Pathway.
    Title: Effect of COP1 in Promoting the Tumorigenesis of Gastric Cancer by Down-Regulation of CDH18 via PI3K/AKT Signal Pathway.
  5. A COP1-GATA2 axis suppresses AR signaling and prostate cancer.
    Title: A COP1-GATA2 axis suppresses AR signaling and prostate cancer.
  6. COP1 Acts as a Ubiquitin Ligase for PCDH9 Ubiquitination and Degradation in Human Glioma.
    Title: COP1 Acts as a Ubiquitin Ligase for PCDH9 Ubiquitination and Degradation in Human Glioma.
  7. Role of the COP1 protein in cancer development and therapy.
    Title: Role of the COP1 protein in cancer development and therapy.
  8. RFWD2 induces cellular proliferation and selective proteasome inhibitor resistance by mediating P27 ubiquitination in multiple myeloma.
    Title: RFWD2 induces cellular proliferation and selective proteasome inhibitor resistance by mediating P27 ubiquitination in multiple myeloma.
  9. Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPbeta in Microglia.
    Title: Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia.
  10. Palmitate induces COP1 expression in hepG2 cells. COP1 functioned as an E3 Ub-ligase of SIRT1, responsible for its proteasomal degradation under lipotoxic conditions. TRB3 recruited COP1 to SIRT1 to promote its ubiquitination.The TRB3-COP1-SIRT1 pathway played an important role in lipotoxicity leading to insulin resistance in hepatocytes.
    Title: TRB3 stimulates SIRT1 degradation and induces insulin resistance by lipotoxicity via COP1.
Submit: New GeneRIF Correction See all GeneRIFs (51)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10416, RP11-318C24.3

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in response to ionizing radiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul4A-RING E3 ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase COP1
Names
E3 ubiquitin-protein ligase RFWD2
RING finger protein 200
RING-type E3 ubiquitin transferase RFWD2
constitutive photomorphogenesis protein 1 homolog
constitutive photomorphogenic protein 1
putative ubiquitin ligase COP1
ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
NP_001001740.1
NP_001273573.1
NP_071902.2
XP_005245504.1
XP_005245505.1
XP_006711550.1
XP_011508183.1
XP_016857548.1
XP_016857549.1
XP_016857550.1
XP_016857551.1
XP_016857552.1
XP_016857553.1
XP_016857554.1
XP_016857555.1
XP_016857556.1
XP_016857558.1
XP_016857560.1
XP_016857561.1
XP_016857562.1
XP_016857563.1
XP_016857566.1
XP_016857569.1
XP_047283718.1
XP_047283734.1
XP_047283736.1
XP_047283738.1
XP_047283742.1
XP_047283749.1
XP_047283754.1
XP_047283755.1
XP_054194157.1
XP_054194158.1
XP_054194159.1
XP_054194160.1
XP_054194161.1
XP_054194162.1
XP_054194163.1
XP_054194164.1
XP_054194165.1
XP_054194166.1
XP_054194167.1
XP_054194168.1
XP_054194169.1
XP_054194170.1
XP_054194171.1
XP_054194172.1
XP_054194173.1
XP_054194174.1
XP_054194175.1
XP_054194176.1
XP_054194177.1
XP_054194178.1
XP_054194179.1
XP_054194180.1
XP_054194181.1
XP_054194182.1
XP_054194183.1
XP_054194184.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001740.4 → NP_001001740.1  E3 ubiquitin-protein ligase COP1 isoform b

    See identical proteins and their annotated locations for NP_001001740.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b, also known as delta24) is shorter, compared to isoform a.
    Source sequence(s)
    AF527539, AL359265, AY509921, BG717002, CA450176
    Consensus CDS
    CCDS44279.1
    UniProtKB/TrEMBL
    X5DR91
    Related
    ENSP00000310943.8, ENST00000308769.12
    Conserved Domains (3) summary
    PLN00181
    Location:236 → 707
    PLN00181; protein SPA1-RELATED; Provisional
    sd00039
    Location:449 → 486
    7WD40; WD40 repeat [structural motif]
    cd16504
    Location:132 → 177
    RING-HC_COP1; RING finger, HC subclass, found in constitutive photomorphogenesis protein 1 (COP1) and similar proteins

  2. NM_001286644.2 → NP_001273573.1  E3 ubiquitin-protein ligase COP1 isoform c precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a shorter and distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AF527539, AL359265, BC039723, BG717002
    UniProtKB/TrEMBL
    H0Y339
    Related
    ENSP00000356638.1, ENST00000367666.5
    Conserved Domains (2) summary
    PLN00181
    Location:22 → 491
    PLN00181; protein SPA1-RELATED; Provisional
    sd00039
    Location:185 → 228
    7WD40; WD40 repeat [structural motif]

  3. NM_022457.7 → NP_071902.2  E3 ubiquitin-protein ligase COP1 isoform a

    See identical proteins and their annotated locations for NP_071902.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL359265, BC094728, BG717002
    Consensus CDS
    CCDS30944.1
    UniProtKB/Swiss-Prot
    E9PKI0, Q504W6, Q6H103, Q8NHY2, Q9H6L7, X5D9B4
    UniProtKB/TrEMBL
    X5DR91
    Related
    ENSP00000356641.3, ENST00000367669.8
    Conserved Domains (3) summary
    PLN00181
    Location:240 → 731
    PLN00181; protein SPA1-RELATED; Provisional
    sd00039
    Location:473 → 510
    7WD40; WD40 repeat [structural motif]
    cd16504
    Location:132 → 177
    RING-HC_COP1; RING finger, HC subclass, found in constitutive photomorphogenesis protein 1 (COP1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    175944831..176207286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427793.1 → XP_047283749.1  E3 ubiquitin-protein ligase COP1 isoform X20

  2. XM_047427798.1 → XP_047283754.1  E3 ubiquitin-protein ligase COP1 isoform X25

  3. XM_047427786.1 → XP_047283742.1  E3 ubiquitin-protein ligase COP1 isoform X18

  4. XM_047427782.1 → XP_047283738.1  E3 ubiquitin-protein ligase COP1 isoform X15

  5. XM_005245447.4 → XP_005245504.1  E3 ubiquitin-protein ligase COP1 isoform X13

    See identical proteins and their annotated locations for XP_005245504.1

    UniProtKB/TrEMBL
    X5DR91
    Conserved Domains (3) summary
    PLN00181
    Location:236 → 727
    PLN00181; protein SPA1-RELATED; Provisional
    sd00039
    Location:469 → 506
    7WD40; WD40 repeat [structural motif]
    cd16504
    Location:132 → 177
    RING-HC_COP1; RING finger, HC subclass, found in constitutive photomorphogenesis protein 1 (COP1) and similar proteins

  6. XM_047427762.1 → XP_047283718.1  E3 ubiquitin-protein ligase COP1 isoform X8

  7. XM_006711487.4 → XP_006711550.1  E3 ubiquitin-protein ligase COP1 isoform X17

    See identical proteins and their annotated locations for XP_006711550.1

    UniProtKB/TrEMBL
    X5DNY7, X5DR91
    Conserved Domains (3) summary
    PLN00181
    Location:240 → 708
    PLN00181; protein SPA1-RELATED; Provisional
    sd00039
    Location:450 → 487
    7WD40; WD40 repeat [structural motif]
    cd16504
    Location:132 → 177
    RING-HC_COP1; RING finger, HC subclass, found in constitutive photomorphogenesis protein 1 (COP1) and similar proteins

  8. XM_047427780.1 → XP_047283736.1  E3 ubiquitin-protein ligase COP1 isoform X14

  9. XM_005245448.4 → XP_005245505.1  E3 ubiquitin-protein ligase COP1 isoform X16

    See identical proteins and their annotated locations for XP_005245505.1

    UniProtKB/TrEMBL
    X5D7N8, X5DR91
    Conserved Domains (3) summary
    PLN00181
    Location:240 → 711
    PLN00181; protein SPA1-RELATED; Provisional
    sd00039
    Location:453 → 490
    7WD40; WD40 repeat [structural motif]
    cd16504
    Location:132 → 177
    RING-HC_COP1; RING finger, HC subclass, found in constitutive photomorphogenesis protein 1 (COP1) and similar proteins

  10. XM_047427778.1 → XP_047283734.1  E3 ubiquitin-protein ligase COP1 isoform X12

  11. XM_011509881.3 → XP_011508183.1  E3 ubiquitin-protein ligase COP1 isoform X7

    UniProtKB/TrEMBL
    X5DR91
    Conserved Domains (3) summary
    PLN00181
    Location:240 → 749
    PLN00181; protein SPA1-RELATED; Provisional
    sd00039
    Location:491 → 528
    7WD40; WD40 repeat [structural motif]
    cd16504
    Location:132 → 177
    RING-HC_COP1; RING finger, HC subclass, found in constitutive photomorphogenesis protein 1 (COP1) and similar proteins

  12. XM_017002069.3 → XP_016857558.1  E3 ubiquitin-protein ligase COP1 isoform X19

    UniProtKB/TrEMBL
    X5D9B8
    Conserved Domains (3) summary
    PLN00181
    Location:210 → 563
    PLN00181; protein SPA1-RELATED; Provisional
    sd00039
    Location:281 → 324
    7WD40; WD40 repeat [structural motif]
    cd16504
    Location:132 → 155
    RING-HC_COP1; RING finger, HC subclass, found in constitutive photomorphogenesis protein 1 (COP1) and similar proteins

  13. XM_017002074.2 → XP_016857563.1  E3 ubiquitin-protein ligase COP1 isoform X24

    Conserved Domains (2) summary
    PLN00181
    Location:104 → 457
    PLN00181; protein SPA1-RELATED; Provisional
    sd00039
    Location:175 → 218
    7WD40; WD40 repeat [structural motif]

  14. XM_017002072.2 → XP_016857561.1  E3 ubiquitin-protein ligase COP1 isoform X22

    Conserved Domains (2) summary
    PLN00181
    Location:6 → 477
    PLN00181; protein SPA1-RELATED; Provisional
    sd00039
    Location:195 → 238
    7WD40; WD40 repeat [structural motif]

  15. XM_017002067.3 → XP_016857556.1  E3 ubiquitin-protein ligase COP1 isoform X11

    UniProtKB/TrEMBL
    X5DR91
    Conserved Domains (3) summary
    PLN00181
    Location:236 → 683
    PLN00181; protein SPA1-RELATED; Provisional
    sd00039
    Location:449 → 486
    7WD40; WD40 repeat [structural motif]
    cd16504
    Location:132 → 177
    RING-HC_COP1; RING finger, HC subclass, found in constitutive photomorphogenesis protein 1 (COP1) and similar proteins

  16. XM_017002063.3 → XP_016857552.1  E3 ubiquitin-protein ligase COP1 isoform X5

    UniProtKB/TrEMBL
    X5DR91
    Conserved Domains (3) summary
    PLN00181
    Location:236 → 703
    PLN00181; protein SPA1-RELATED; Provisional
    sd00039
    Location:469 → 506
    7WD40; WD40 repeat [structural motif]
    cd16504
    Location:132 → 177
    RING-HC_COP1; RING finger, HC subclass, found in constitutive photomorphogenesis protein 1 (COP1) and similar proteins

  17. XM_017002060.3 → XP_016857549.1  E3 ubiquitin-protein ligase COP1 isoform X2

    UniProtKB/TrEMBL
    X5DR91
    Conserved Domains (3) summary
    PLN00181
    Location:236 → 721
    PLN00181; protein SPA1-RELATED; Provisional
    sd00039
    Location:487 → 524
    7WD40; WD40 repeat [structural motif]
    cd16504
    Location:132 → 177
    RING-HC_COP1; RING finger, HC subclass, found in constitutive photomorphogenesis protein 1 (COP1) and similar proteins

  18. XM_017002066.3 → XP_016857555.1  E3 ubiquitin-protein ligase COP1 isoform X10

    UniProtKB/TrEMBL
    X5DR91
    Conserved Domains (3) summary
    PLN00181
    Location:240 → 684
    PLN00181; protein SPA1-RELATED; Provisional
    sd00039
    Location:450 → 487
    7WD40; WD40 repeat [structural motif]
    cd16504
    Location:132 → 177
    RING-HC_COP1; RING finger, HC subclass, found in constitutive photomorphogenesis protein 1 (COP1) and similar proteins

  19. XM_017002064.3 → XP_016857553.1  E3 ubiquitin-protein ligase COP1 isoform X6

    UniProtKB/TrEMBL
    X5DR91
    Conserved Domains (3) summary
    PLN00181
    Location:240 → 702
    PLN00181; protein SPA1-RELATED; Provisional
    sd00039
    Location:468 → 505
    7WD40; WD40 repeat [structural motif]
    cd16504
    Location:132 → 177
    RING-HC_COP1; RING finger, HC subclass, found in constitutive photomorphogenesis protein 1 (COP1) and similar proteins

  20. XM_017002065.3 → XP_016857554.1  E3 ubiquitin-protein ligase COP1 isoform X9

    UniProtKB/TrEMBL
    X5DR91
    Conserved Domains (3) summary
    PLN00181
    Location:240 → 687
    PLN00181; protein SPA1-RELATED; Provisional
    sd00039
    Location:453 → 490
    7WD40; WD40 repeat [structural motif]
    cd16504
    Location:132 → 177
    RING-HC_COP1; RING finger, HC subclass, found in constitutive photomorphogenesis protein 1 (COP1) and similar proteins

  21. XM_017002062.3 → XP_016857551.1  E3 ubiquitin-protein ligase COP1 isoform X4

    UniProtKB/TrEMBL
    X5DR91
    Conserved Domains (3) summary
    PLN00181
    Location:240 → 705
    PLN00181; protein SPA1-RELATED; Provisional
    sd00039
    Location:471 → 508
    7WD40; WD40 repeat [structural motif]
    cd16504
    Location:132 → 177
    RING-HC_COP1; RING finger, HC subclass, found in constitutive photomorphogenesis protein 1 (COP1) and similar proteins

  22. XM_017002061.3 → XP_016857550.1  E3 ubiquitin-protein ligase COP1 isoform X3

    UniProtKB/TrEMBL
    X5DR91
    Conserved Domains (3) summary
    PLN00181
    Location:240 → 707
    PLN00181; protein SPA1-RELATED; Provisional
    sd00039
    Location:473 → 510
    7WD40; WD40 repeat [structural motif]
    cd16504
    Location:132 → 177
    RING-HC_COP1; RING finger, HC subclass, found in constitutive photomorphogenesis protein 1 (COP1) and similar proteins

  23. XM_017002059.3 → XP_016857548.1  E3 ubiquitin-protein ligase COP1 isoform X1

    UniProtKB/TrEMBL
    X5DR91
    Conserved Domains (3) summary
    PLN00181
    Location:240 → 725
    PLN00181; protein SPA1-RELATED; Provisional
    sd00039
    Location:491 → 528
    7WD40; WD40 repeat [structural motif]
    cd16504
    Location:132 → 177
    RING-HC_COP1; RING finger, HC subclass, found in constitutive photomorphogenesis protein 1 (COP1) and similar proteins

  24. XM_017002073.2 → XP_016857562.1  E3 ubiquitin-protein ligase COP1 isoform X23

    Conserved Domains (2) summary
    PLN00181
    Location:112 → 465
    PLN00181; protein SPA1-RELATED; Provisional
    sd00039
    Location:183 → 226
    7WD40; WD40 repeat [structural motif]

  25. XM_017002071.2 → XP_016857560.1  E3 ubiquitin-protein ligase COP1 isoform X21

    Conserved Domains (2) summary
    PLN00181
    Location:22 → 485
    PLN00181; protein SPA1-RELATED; Provisional
    sd00039
    Location:203 → 246
    7WD40; WD40 repeat [structural motif]

  26. XM_017002080.3 → XP_016857569.1  E3 ubiquitin-protein ligase COP1 isoform X27

    Conserved Domains (2) summary
    PLN00181
    Location:52 → 405
    PLN00181; protein SPA1-RELATED; Provisional
    sd00039
    Location:123 → 166
    7WD40; WD40 repeat [structural motif]

  27. XM_047427799.1 → XP_047283755.1  E3 ubiquitin-protein ligase COP1 isoform X27

  28. XM_017002077.3 → XP_016857566.1  E3 ubiquitin-protein ligase COP1 isoform X26

    Conserved Domains (2) summary
    PLN00181
    Location:74 → 427
    PLN00181; protein SPA1-RELATED; Provisional
    sd00039
    Location:145 → 188
    7WD40; WD40 repeat [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    175300159..175562553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338201.1 → XP_054194176.1  E3 ubiquitin-protein ligase COP1 isoform X20

  2. XM_054338206.1 → XP_054194181.1  E3 ubiquitin-protein ligase COP1 isoform X25

  3. XM_054338199.1 → XP_054194174.1  E3 ubiquitin-protein ligase COP1 isoform X18

  4. XM_054338196.1 → XP_054194171.1  E3 ubiquitin-protein ligase COP1 isoform X15

  5. XM_054338194.1 → XP_054194169.1  E3 ubiquitin-protein ligase COP1 isoform X13

  6. XM_054338189.1 → XP_054194164.1  E3 ubiquitin-protein ligase COP1 isoform X8

  7. XM_054338198.1 → XP_054194173.1  E3 ubiquitin-protein ligase COP1 isoform X17

    UniProtKB/TrEMBL
    X5DNY7

  8. XM_054338195.1 → XP_054194170.1  E3 ubiquitin-protein ligase COP1 isoform X14

  9. XM_054338197.1 → XP_054194172.1  E3 ubiquitin-protein ligase COP1 isoform X16

    UniProtKB/TrEMBL
    X5D7N8

  10. XM_054338193.1 → XP_054194168.1  E3 ubiquitin-protein ligase COP1 isoform X12

  11. XM_054338188.1 → XP_054194163.1  E3 ubiquitin-protein ligase COP1 isoform X7

  12. XM_054338200.1 → XP_054194175.1  E3 ubiquitin-protein ligase COP1 isoform X19

  13. XM_054338205.1 → XP_054194180.1  E3 ubiquitin-protein ligase COP1 isoform X24

  14. XM_054338203.1 → XP_054194178.1  E3 ubiquitin-protein ligase COP1 isoform X22

  15. XM_054338192.1 → XP_054194167.1  E3 ubiquitin-protein ligase COP1 isoform X11

  16. XM_054338186.1 → XP_054194161.1  E3 ubiquitin-protein ligase COP1 isoform X5

  17. XM_054338183.1 → XP_054194158.1  E3 ubiquitin-protein ligase COP1 isoform X2

  18. XM_054338191.1 → XP_054194166.1  E3 ubiquitin-protein ligase COP1 isoform X10

  19. XM_054338187.1 → XP_054194162.1  E3 ubiquitin-protein ligase COP1 isoform X6

  20. XM_054338190.1 → XP_054194165.1  E3 ubiquitin-protein ligase COP1 isoform X9

  21. XM_054338185.1 → XP_054194160.1  E3 ubiquitin-protein ligase COP1 isoform X4

  22. XM_054338184.1 → XP_054194159.1  E3 ubiquitin-protein ligase COP1 isoform X3

  23. XM_054338182.1 → XP_054194157.1  E3 ubiquitin-protein ligase COP1 isoform X1

  24. XM_054338204.1 → XP_054194179.1  E3 ubiquitin-protein ligase COP1 isoform X23

  25. XM_054338202.1 → XP_054194177.1  E3 ubiquitin-protein ligase COP1 isoform X21

  26. XM_054338209.1 → XP_054194184.1  E3 ubiquitin-protein ligase COP1 isoform X27

  27. XM_054338208.1 → XP_054194183.1  E3 ubiquitin-protein ligase COP1 isoform X27

  28. XM_054338207.1 → XP_054194182.1  E3 ubiquitin-protein ligase COP1 isoform X26

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NHY2.1 GenPept UniProtKB/Swiss-Prot:Q8NHY2

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