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Araf A-Raf proto-oncogene, serine/threonine kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 64363, updated on 27-Nov-2024

Summary

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Official Symbol
Arafprovided by RGD
Official Full Name
A-Raf proto-oncogene, serine/threonine kinaseprovided by RGD
Primary source
RGD:2148
See related
EnsemblRapid:ENSRNOG00000010838 AllianceGenome:RGD:2148
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Araf1
Summary
Enables MAP kinase kinase kinase activity. Involved in protein phosphorylation. Predicted to be active in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human ARAF (A-Raf proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 202.0), Heart (RPKM 181.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Araf in Genome Data Viewer
Location:
Xq11
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (3780932..3845919, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (1227392..1292356, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (1369534..1391603, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene synapsin I Neighboring gene 60S ribosomal protein L12-like Neighboring gene TIMP metallopeptidase inhibitor 1 Neighboring gene uncharacterized LOC134484040 Neighboring gene small ribosomal subunit protein eS24-like Neighboring gene ribosomal protein L22 like 1, pseudogene 1 Neighboring gene prothymosin alpha like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The complete primary structure of the rat A-raf cDNA coding region: conservation of the putative regulatory regions present in rat c-raf. Ishikawa F, et al. Oncogene Res, 1987 Aug. PMID 3449797
  2. IGFBP2 expression predicts IDH-mutant glioma patient survival. Huang LE, et al. Oncotarget, 2017 Jan 3. PMID 27852048, Free PMC Article
  3. Characterization of murine A-raf, a new oncogene related to the v-raf oncogene. Huleihel M, et al. Mol Cell Biol, 1986 Jul. PMID 3491291, Free PMC Article
  4. DA-Raf1, a competent intrinsic dominant-negative antagonist of the Ras-ERK pathway, is required for myogenic differentiation. Yokoyama T, et al. J Cell Biol, 2007 Jun 4. PMID 17535970, Free PMC Article
  5. Hepatic epidermal growth factor-regulated mitogen-activated protein kinase kinase kinase activity in the rat: lack of identity with known forms of raf and MEKK. Gruppuso PA, et al. FEBS Lett, 2000 Jan 21. PMID 10648842

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase kinase kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP kinase kinase kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase A-Raf
Names
A-Raf proto-oncogene serine/threonine-protein kinase
Raf related protein
Ras-binding protein
proto-oncogene A-Raf
proto-oncogene A-Raf-1
v-raf murine sarcoma 3611 viral oncogene homolog 1
v-raf oncogene homolog 1 (murine sarcoma 3611 virus)
NP_001028835.1
NP_071977.1
XP_038955949.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033663.2 → NP_001028835.1  serine/threonine-protein kinase A-Raf isoform 2

    See identical proteins and their annotated locations for NP_001028835.1

    Status: VALIDATED

    Source sequence(s)
    AB158253, AI060060, CO572305, DV728203
    UniProtKB/TrEMBL
    A0A8I5ZXA9, A6JZR7, A6JZR9, A6JZS1, Q6P9W2
    Conserved Domains (2) summary
    cd01816
    Location:20 → 91
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    pfam00130
    Location:99 → 146
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  2. NM_022532.2 → NP_071977.1  serine/threonine-protein kinase A-Raf isoform 1

    See identical proteins and their annotated locations for NP_071977.1

    Status: VALIDATED

    Source sequence(s)
    AI712552, CO572305, X06942
    UniProtKB/Swiss-Prot
    P14056
    UniProtKB/TrEMBL
    A6JZR3, A6JZR6
    Related
    ENSRNOP00000048890.6, ENSRNOT00000039911.5
    Conserved Domains (4) summary
    cd01816
    Location:20 → 91
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    pfam00069
    Location:309 → 563
    Pkinase; Protein kinase domain
    pfam00130
    Location:99 → 146
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:307 → 571
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    3780932..3845919 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039100021.2 → XP_038955949.1  serine/threonine-protein kinase A-Raf isoform X1

    UniProtKB/TrEMBL
    A6JZR2, A6JZR3
    Conserved Domains (3) summary
    cd17133
    Location:56 → 128
    RBD_ARAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase ARAF
    cd20870
    Location:133 → 184
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins
    cl21453
    Location:344 → 608
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14056.1 GenPept UniProtKB/Swiss-Prot:P14056

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