Gpr88 G-protein coupled receptor 88 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpr88provided by MGI
Official Full Name: G-protein coupled receptor 88provided by MGI
Primary source: MGI:MGI:1927653
See related: Ensembl:ENSMUSG00000068696 AllianceGenome:MGI:1927653
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Strg
Summary: Enables cytoskeletal motor activity. Involved in motor learning. Acts upstream of or within locomotory behavior; neuromuscular process controlling balance; and neuronal action potential. Predicted to be located in ciliary membrane; cytoplasm; and nucleus. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; ear; genitourinary system; nervous system; and skeleton. Orthologous to human GPR88 (G protein-coupled receptor 88). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cortex adult (RPKM 16.3), CNS E18 (RPKM 8.2) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 50.23 cM; 3 G1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (116043304..116047123, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (116249654..116253540, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Orphan GPCR Receptor, GPR88, Interacts with Nuclear Protein Partners in the Cerebral Cortex.
Title: The Orphan GPCR Receptor, GPR88, Interacts with Nuclear Protein Partners in the Cerebral Cortex.
Impaired working memory, cognitive flexibility and reward processing in mice genetically lacking Gpr88: Evidence for a key role for Gpr88 in multiple cortico-striatal-thalamic circuits.
Title: Impaired working memory, cognitive flexibility and reward processing in mice genetically lacking Gpr88: Evidence for a key role for Gpr88 in multiple cortico-striatal-thalamic circuits.
The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRs.
Title: The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRs.
Genetic deletion of GPR88 enhances the locomotor response to L-DOPA in experimental parkinsonism while counteracting the induction of dyskinesia.
Title: Genetic deletion of GPR88 enhances the locomotor response to L-DOPA in experimental parkinsonism while counteracting the induction of dyskinesia.
Study suggests that GPR88 in dopamine d2 receptor medium spiny neurons shapes defensive and social behavior and contributes in maintaining the inhibition of basal ganglia outputs to control locomotion, stereotypies and motor coordination, while GPR88 in D1R-MSNs promotes novelty habituation and motor learning.
Title: GPR88 in D1R-Type and D2R-Type Medium Spiny Neurons Differentially Regulates Affective and Motor Behavior.
Gpr88 deletion disrupts executive, reward, and emotional networks in a configuration that reduces alcohol reward and promotes alcohol seeking and drinking. The functional connectivity signature is reminiscent of alterations observed in individuals at risk for Alcohol use disorder.
Title: Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks.
G-protein coupled receptor 88 knockout (Gpr88 (-/-)) mice showed significantly reduced adiposity accompanied with suppressed spontaneous food intake, particularly pronounced under high fat diet (HFD) treatment.
Title: GPR88 is a critical regulator of feeding and body composition in mice.
The data of this study suggested that primary sensory perception (olfaction and vision) is intact, but the loss of Gpr88 contributes to delayed behavioral responses that require sensory processing.
Title: Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing.
GPR88 in A2A receptor-expressing neurons modulates psychomotor behavior but not sensorimotor gating.
Title: GPR88 in A(2A) receptor-expressing neurons modulates locomotor response to dopamine agonists but not sensorimotor gating.
GPR88 activity shapes the mouse brain functional and structural connectome
Title: Remodeling of Sensorimotor Brain Connectivity in Gpr88-Deficient Mice.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (6) 1 citation

General gene information

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Markers

Gpr88 (e-PCR), detects polymorphism
- UniSTS:506949

AW061286 (e-PCR)
- UniSTS:178921

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled photoreceptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables beta2-adrenergic receptor activity	ISO Inferred from Sequence Orthology more info
enables beta2-adrenergic receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables cytoskeletal motor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to light stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor learning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromuscular process controlling balance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in ciliary membrane	ISO Inferred from Sequence Orthology more info
located_in ciliary membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cilium	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: G protein-coupled receptor 88

Names: probable G-protein coupled receptor 88; striatum-specific G-protein coupled receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411424.1 → NP_001398353.1 G protein-coupled receptor 88

Status: VALIDATED

Source sequence(s)

AC122888

UniProtKB/Swiss-Prot

Q9EPB7

UniProtKB/TrEMBL

B2RXU4
NM_001411425.1 → NP_001398354.1 G protein-coupled receptor 88

Status: VALIDATED

Source sequence(s)

AC122888

UniProtKB/Swiss-Prot

Q9EPB7

UniProtKB/TrEMBL

B2RXU4
NM_001411426.1 → NP_001398355.1 G protein-coupled receptor 88

Status: VALIDATED

Source sequence(s)

AC122888

UniProtKB/Swiss-Prot

Q9EPB7

UniProtKB/TrEMBL

B2RXU4
NM_022427.3 → NP_071872.1 G protein-coupled receptor 88

See identical proteins and their annotated locations for NP_071872.1

Status: VALIDATED

Source sequence(s)

AC122888

Consensus CDS

CCDS38610.1

UniProtKB/Swiss-Prot

Q9EPB7

UniProtKB/TrEMBL

B2RXU4

Related

ENSMUSP00000087959.6, ENSMUST00000090473.7

Conserved Domains (2) summary

cd14964
Location:34 → 58

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:33 → 347

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily