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ACTR6 actin related protein 6 [ Homo sapiens (human) ]

Gene ID: 64431, updated on 27-Nov-2024

Summary

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Official Symbol
ACTR6provided by HGNC
Official Full Name
actin related protein 6provided by HGNC
Primary source
HGNC:HGNC:24025
See related
Ensembl:ENSG00000075089 MIM:619729; AllianceGenome:HGNC:24025
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARP6; CDA12; hARP6; hARPX; HSPC281; MSTP136
Summary
Predicted to enable nucleosome binding activity. Involved in nucleolus organization. Located in nucleolus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 10.9), testis (RPKM 9.8) and 25 other tissues See more
Orthologs
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Genomic context

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See ACTR6 in Genome Data Viewer
Location:
12q23.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (100200815..100224424)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (100162055..100185664)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (100594593..100618202)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:100556980-100557712 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:100559806-100560306 Neighboring gene RNA, 7SL, cytoplasmic 176, pseudogene Neighboring gene GOLGA2 pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6853 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4764 Neighboring gene Sharpr-MPRA regulatory region 7946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6854 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:100595701-100596388 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:100596389-100597074 Neighboring gene microRNA 1827 Neighboring gene DEP domain containing 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6856 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4765 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6857 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4766 Neighboring gene MPRA-validated peak1911 silencer Neighboring gene SCY1 like pseudokinase 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:100688535-100689176 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:100689177-100689817 Neighboring gene Sharpr-MPRA regulatory region 7724 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6859 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:100724514-100724735 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:100750302-100750802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:100750803-100751303 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr12:100766477-100767226 Neighboring gene solute carrier family 17 member 8 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The actin family protein ARP6 contributes to the structure and the function of the nucleolus. Kitamura H, et al. Biochem Biophys Res Commun, 2015 Aug 21. PMID 26164235, Free PMC Article
  2. Novel actin-related proteins in vertebrates: similarities of structure and expression pattern to Arp6 localized on Drosophila heterochromatin. Kato M, et al. Gene, 2001 May 2. PMID 11368909
  3. Vertebrate Arp6, a novel nuclear actin-related protein, interacts with heterochromatin protein 1. Ohfuchi E, et al. Eur J Cell Biol, 2006 May. PMID 16487625
  4. Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation. Cuadrado A, et al. EMBO J, 2010 Jun 16. PMID 20473270, Free PMC Article
  5. Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes. Ruhl DD, et al. Biochemistry, 2006 May 2. PMID 16634648

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13433

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase I ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nucleolus organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase I ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of Swr1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleosome NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
actin-related protein 6
Names
ARP6 actin related protein 6 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022496.5 → NP_071941.1  actin-related protein 6

    See identical proteins and their annotated locations for NP_071941.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes a protein of 396aa.
    Source sequence(s)
    AB038229, AK124075
    Consensus CDS
    CCDS9074.1
    UniProtKB/Swiss-Prot
    B3KW37, B4DLG9, Q53GH2, Q9BY39, Q9GZN1, Q9H8H6
    Related
    ENSP00000188312.2, ENST00000188312.7
    Conserved Domains (1) summary
    smart00268
    Location:2 → 394
    ACTIN; Actin

RNA

  1. NR_048568.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site at the 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region and is likely a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC050679, DB022992
    Related
    ENST00000546902.5

  2. NR_048569.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate splice site in the 5' region, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region and is likely a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB038229, AK023684, DB022992
    Related
    ENST00000548180.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    100200815..100224424
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    100162055..100185664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GZN1.1 GenPept UniProtKB/Swiss-Prot:Q9GZN1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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