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Tspan2 tetraspanin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64521, updated on 27-Nov-2024

Summary

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Official Symbol
Tspan2provided by RGD
Official Full Name
tetraspanin 2provided by RGD
Primary source
RGD:620982
See related
EnsemblRapid:ENSRNOG00000082472 AllianceGenome:RGD:620982
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tspan-2
Summary
Predicted to act upstream of or within inflammatory response and nervous system development. Predicted to be located in myelin sheath and nucleoplasm. Predicted to be active in plasma membrane. Orthologous to human TSPAN2 (tetraspanin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 362.4), Brain (RPKM 341.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tspan2 in Genome Data Viewer
Location:
2q34
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (192866212..192923489)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (190177717..190234994)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (205160405..205202766)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene nerve growth factor Neighboring gene uncharacterized LOC102549793 Neighboring gene uncharacterized LOC134485941 Neighboring gene uncharacterized LOC134485942 Neighboring gene thyroid stimulating hormone subunit beta Neighboring gene synaptonemal complex protein 1 Neighboring gene nuclear receptor subfamily 1, group H, member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel rat tetraspan protein in cells of the oligodendrocyte lineage. Birling MC, et al. J Neurochem, 1999 Dec. PMID 10582623
  2. Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin-2. de Monasterio-Schrader P, et al. Glia, 2013 Nov. PMID 24038504
  3. Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Gobert RP, et al. Mol Cell Biol, 2009 Mar. PMID 19139271, Free PMC Article
  4. Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b. Wansleeben C, et al. Development, 2010 Apr. PMID 20215345
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within astrocyte development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within axon development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inflammatory response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within microglia development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within myelination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in myelin sheath ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tetraspanin-2
Names
tetraspan 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022589.2 → NP_072111.1  tetraspanin-2

    See identical proteins and their annotated locations for NP_072111.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q9JJW1
    UniProtKB/TrEMBL
    A6K3J1
    Related
    ENSRNOP00000106244.1, ENSRNOT00000168273.1
    Conserved Domains (2) summary
    cd03151
    Location:110 → 186
    CD81_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10 → 214
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    192866212..192923489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_005500365.2 RNA Sequence

  2. XR_005500364.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJW1.1 GenPept UniProtKB/Swiss-Prot:Q9JJW1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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