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Adcy5 adenylate cyclase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64532, updated on 4-Jan-2025

Summary

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Official Symbol
Adcy5provided by RGD
Official Full Name
adenylate cyclase 5provided by RGD
Primary source
RGD:71014
See related
EnsemblRapid:ENSRNOG00000002229 AllianceGenome:RGD:71014
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables calcium- and calmodulin-responsive adenylate cyclase activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; and heart development. Located in endosome and sarcolemma. Biomarker of hypertension and type 2 diabetes mellitus. Orthologous to human ADCY5 (adenylate cyclase 5). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 212.1), Brain (RPKM 104.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Adcy5 in Genome Data Viewer
Location:
11q22
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (78976861..79123343, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (65471612..65618877, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (68695839..68842452, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene protein disulfide isomerase family A, member 5 Neighboring gene uncharacterized LOC120095660 Neighboring gene SEC22 homolog A, vesicle trafficking protein Neighboring gene uncharacterized LOC102551038 Neighboring gene uncharacterized LOC134481009 Neighboring gene 3-hydroxyacyl-CoA dehydratase 2 Neighboring gene uncharacterized LOC134481011 Neighboring gene myosin light chain kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Sensing Positive versus Negative Reward Signals through Adenylyl Cyclase-Coupled GPCRs in Direct and Indirect Pathway Striatal Medium Spiny Neurons. Nair AG, et al. J Neurosci, 2015 Oct 14. PMID 26468202, Free PMC Article
  2. Increased expression of adenylyl cyclase isoforms in the adrenal gland of diabetic Goto-Kakizaki rat. Portela-Gomes GM, et al. Appl Immunohistochem Mol Morphol, 2002 Dec. PMID 12607610
  3. Effect of beta-adrenoceptor antagonist and angiotensin-converting enzyme inhibitor on hypertension-associated changes in adenylyl cyclase type V messenger RNA expression in spontaneously hypertensive rats. Fujino T, et al. J Cardiovasc Pharmacol, 2003 May. PMID 12717102
  4. Adenylate cyclase 5 and KCa1.1 channel are required for EGFR up-regulation of PCNA in native contractile rat basilar artery smooth muscle. Ivanov A, et al. J Physiol, 2006 Jan 1. PMID 16284070, Free PMC Article
  5. ADCY5 couples glucose to insulin secretion in human islets. Hodson DJ, et al. Diabetes, 2014 Sep. PMID 24740569, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Increased expression of adenylyl cyclases V and VI is a major determinant of increased GABAergic transmission in the substantia nigra pars reticulata of animals in which L-DOPA induces severe dyskinesia.
    Title: L-DOPA-induced dyskinesia in hemiparkinsonian rats is associated with up-regulation of adenylyl cyclase type V/VI and increased GABA release in the substantia nigra reticulata.
  2. The decrease in beta(2)-AR may account for additional relaxation impairment, given that there is no enhancement over nontransgenic after pertussis toxin, despite AC5 overexpression.
    Title: Paradoxical attenuation of β2-AR function in airway smooth muscle by Gi-mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclase.
  3. All MOR, D1 and D2 positive cells containing AC5 mRNA simultaneously express PDE7B in striatal rat cells.
    Title: Dopamine D1, D2 and mu-opioid receptors are co-expressed with adenylyl cyclase 5 and phosphodiesterase 7B mRNAs in striatal rat cells.
  4. Describe developmental expression of adenylyl cyclase 5.
    Title: Adenylyl cyclase type 5 protein expression during cardiac development and stress.
  5. The association of AC5 with the AKAP6 complex is required for the regulation of cAMP second messenger controlling cardiac myocyte hypertrophy.
    Title: An adenylyl cyclase-mAKAPbeta signaling complex regulates cAMP levels in cardiac myocytes.
  6. Taken together, these results suggest an essential role of AC5 in the NAc for maintaining normal levels of anxiety.
    Title: Adenylyl cyclase-5 activity in the nucleus accumbens regulates anxiety-related behavior.
  7. K(ATP) channels localize adenylyl cyclase to smooth muscle membrane fractions containing caveolin. To permit protein kinase A-dependent activation, arterial K(ATP) channels need to be in the same lipid compartment as adenylyl cyclase.
    Title: Caveolae localize protein kinase A signaling to arterial ATP-sensitive potassium channels.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
  
enables adenylate cyclase binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium- and calmodulin-responsive adenylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables scaffold protein binding IEA
Inferred from Electronic Annotation
more info
  
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled adenosine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within G protein-coupled adenosine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in adenylate cyclase-activating dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within adenylate cyclase-activating dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within adenylate cyclase-inhibiting dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cAMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cAMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cAMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to forskolin IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to forskolin ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to forskolin ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in heart development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in locomotory behavior IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within locomotory behavior ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in negative regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuromuscular process controlling balance IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuromuscular process controlling balance ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in sarcolemma IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
adenylate cyclase type 5
Names
ATP pyrophosphate-lyase 5
adenylate cyclase type V
adenylyl cyclase 5
adenylyl cyclase type V
NP_072122.2
XP_017453557.1
XP_038944541.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022600.2 → NP_072122.2  adenylate cyclase type 5

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/Swiss-Prot
    Q04400
    UniProtKB/TrEMBL
    A6IRH3
    Related
    ENSRNOP00000046488.4, ENSRNOT00000049180.4
    Conserved Domains (3) summary
    pfam00211
    Location:1063 → 1257
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:1 → 459
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:669 → 761
    DUF1053; Domain of Unknown Function (DUF1053)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    78976861..79123343 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088613.2 → XP_038944541.1  adenylate cyclase type 5 isoform X1

    UniProtKB/Swiss-Prot
    Q04400
    Conserved Domains (3) summary
    pfam00211
    Location:461 → 634
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:1 → 459
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:669 → 761
    DUF1053; Domain of Unknown Function (DUF1053)

  2. XM_017598068.3 → XP_017453557.1  adenylate cyclase type 5 isoform X2

    UniProtKB/Swiss-Prot
    Q04400
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04400.2 GenPept UniProtKB/Swiss-Prot:Q04400

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