Trpc2 transient receptor potential cation channel subfamily C member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trpc2provided by RGD
Official Full Name: transient receptor potential cation channel subfamily C member 2provided by RGD
Primary source: RGD:628819
See related: EnsemblRapid:ENSRNOG00000020188 AllianceGenome:RGD:628819
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Trrp2
Summary: Predicted to enable diacylglycerol binding activity; inositol 1,4,5 trisphosphate binding activity; and store-operated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport; regulation of cytosolic calcium ion concentration; and single fertilization. Predicted to act upstream of or within several processes, including female courtship behavior; inter-male aggressive behavior; and mating behavior, sex discrimination. Predicted to be located in dendrite membrane and endomembrane system. Predicted to be part of cation channel complex. Predicted to be active in plasma membrane. Orthologous to human TRPC2 (transient receptor potential cation channel subfamily C member 2 (pseudogene)). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 1q32

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (165871991..165885339)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (156460009..156473039)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (167180103..167192456)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRPC2 is an important regulator of rat thyroid cell function.
Title: Significance of the transient receptor potential canonical 2 (TRPC2) channel in the regulation of rat thyroid FRTL-5 cell proliferation, migration, adhesion and invasion.
findings show that TRPC2 is important for posttranslational processing and secretion of thyroglobulin
Title: Communication between the calcium and cAMP pathways regulate the expression of the TSH receptor: TRPC2 in the center of action.
Ca(2+) entry via TRPC2 contributes to CaCC activation.
Title: Functional coupling of TRPC2 cation channels and the calcium-activated anion channels in rat thyroid cells: implications for iodide homeostasis.
TRPC2, by regulating STIM2, PKC expression, and SERCA activity, regulates calcium homeostasis in thyroid cells.
Title: Canonical transient receptor potential channel 2 (TRPC2) as a major regulator of calcium homeostasis in rat thyroid FRTL-5 cells: importance of protein kinase C δ (PKCδ) and stromal interaction molecule 2 (STIM2).
TRPC2 expression and channel activity is regulated by chaperone- and scaffolding-associated proteins, which could modulate the transduction of chemosignals.
Title: The TRPC2 channel forms protein-protein interactions with Homer and RTP in the rat vomeronasal organ.

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General gene information

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Markers

Trpc2 (e-PCR), detects polymorphism
- UniSTS:546048

RH139162 (e-PCR)
- UniSTS:221248

RH130299 (e-PCR)
- UniSTS:213585

PMC152292P2 (e-PCR)
- UniSTS:271216

RH133514 (e-PCR)
- UniSTS:216797

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables diacylglycerol binding	ISO Inferred from Sequence Orthology more info
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables inositol 1,4,5 trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
NOT enables store-operated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables store-operated calcium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within acrosome reaction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within aggressive behavior	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within female courtship behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inter-male aggressive behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mating behavior, sex discrimination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of male mating behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to pheromone	ISO Inferred from Sequence Orthology more info
involved_in single fertilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in single strand break repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within territorial aggressive behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite membrane	ISO Inferred from Sequence Orthology more info
located_in endomembrane system	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: short transient receptor potential channel 2

Names: TRP-2; rTrp2; transient receptor potential cation channel, subfamily C, member 2, pseudogene; transient receptor protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022638.3 → NP_072160.2 short transient receptor potential channel 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A140TAF6

Related

ENSRNOP00000042378.5, ENSRNOT00000045726.6

Conserved Domains (2) summary

TIGR00870
Location:2 → 758

trp; transient-receptor-potential calcium channel protein

sd00045
Location:91 → 136

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

165871991..165885339

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008759812.4 → XP_008758034.2 short transient receptor potential channel 2 isoform X1

UniProtKB/TrEMBL

A0A140TAF6

Conserved Domains (2) summary

TIGR00870
Location:68 → 805

trp; transient-receptor-potential calcium channel protein

sd00045
Location:138 → 183

ANK; ANK repeat [structural motif]