Exoc7 exocyst complex component 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Exoc7provided by RGD
Full Name: exocyst complex component 7provided by RGD
Primary source: RGD:620236
See related: EnsemblRapid:ENSRNOG00000070201 AllianceGenome:RGD:620236
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Exo70
Summary: Predicted to enable protein-macromolecule adaptor activity. Involved in regulation of synapse assembly. Is active in postsynapse and presynapse. Orthologous to human EXOC7 (exocyst complex component 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 137.7), Kidney (RPKM 137.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (102019805..102039333, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (101521630..101540425, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (105242152..105259795, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exo70 is essentially involved in the formation of synapses and neuronal dendritic morphology.
Title: The Exocyst Component Exo70 Modulates Dendrite Arbor Formation, Synapse Density, and Spine Maturation in Primary Hippocampal Neurons.
Exo70 in vascular smooth muscle cell migration. Exo70 and alpha-actin were co-localized at the leading edge of migrating cells.
Title: The role of Exo70 in vascular smooth muscle cell migration.
Exocytosis of Rab11- and L1-positive vesicles may play a central role in TC10-mediated neurite outgrowth
Title: GTP hydrolysis of TC10 promotes neurite outgrowth through exocytic fusion of Rab11- and L1-containing vesicles by releasing exocyst component Exo70.
functions as a kinetic activator of the Arp2/3 complex that promotes actin filament nucleation and branching
Title: Exo70 stimulates the Arp2/3 complex for lamellipodia formation and directional cell migration.
In the rat calyx of Held, exocyst complex component 70 mediates the addition of membrane during postnatal presynaptic maturation.
Title: Acute genetic perturbation of exocyst function in the rat calyx of Held impedes structural maturation, but spares synaptic transmission.
fusion of GLUT4 vesicles is the rate-limiting step regulated by insulin downstream of Exo70-mediated tethering
Title: Insulin regulates fusion of GLUT4 vesicles independent of Exo70-mediated tethering.
Exo70-phosphatidylinositol 4,5-bisphosphate interaction is critical for the docking and fusion of post-Golgi secretory vesicles, but not for their transport to the plasma membrane
Title: Phosphatidylinositol 4,5-bisphosphate mediates the targeting of the exocyst to the plasma membrane for exocytosis in mammalian cells.
Exo70, in addition to functioning in exocytosis, also regulates actin at the leading edges of migrating cells, therefore coordinating cytoskeleton and membrane traffic during cell migration.
Title: Exo70 interacts with the Arp2/3 complex and regulates cell migration.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Cebr2 (e-PCR)
- UniSTS:518729

RH140072 (e-PCR)
- UniSTS:222153

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidylinositol-4,5-bisphosphate binding	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in exocytosis	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of mitotic cytokinetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic cytokinetic process	ISO Inferred from Sequence Orthology more info
involved_in protein transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of entry of bacterium into host cell	IEA Inferred from Electronic Annotation more info
involved_in regulation of entry of bacterium into host cell	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Flemming body	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
part_of exocyst	IBA Inferred from Biological aspect of Ancestor more info
part_of exocyst	IEA Inferred from Electronic Annotation more info
located_in growth cone membrane	IEA Inferred from Electronic Annotation more info
located_in growth cone membrane	ISO Inferred from Sequence Orthology more info
located_in microtubule organizing center	ISO Inferred from Sequence Orthology more info
located_in midbody	IEA Inferred from Electronic Annotation more info
is_active_in midbody	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: exocyst complex component 7

Names: exocyst complex component Exo70; rexo70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.