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Mbl2 mannose binding lectin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64668, updated on 4-Jan-2025

Summary

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Symbol
Mbl2provided by RGD
Full Name
mannose binding lectin 2provided by RGD
Primary source
RGD:67380
See related
EnsemblRapid:ENSRNOG00000011637 AllianceGenome:RGD:67380
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ab2-001; Ab2-011
Summary
Enables several functions, including identical protein binding activity; monosaccharide binding activity; and phosphatidylinositol-4-phosphate binding activity. Involved in positive regulation of complement activation and positive regulation of protein processing. Located in extracellular space. Part of protein-containing complex. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bacterial infectious disease (multiple); fungal infectious disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human MBL2 (mannose binding lectin 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 1618.2) See more
Orthologs
human mouse all
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Genomic context

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See Mbl2 in Genome Data Viewer
Location:
1q52
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (237429873..237465567)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (228016439..228024736)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (248435069..248442669)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 4, pseudogene 1 Neighboring gene cytochrome c, somatic, pseudogene 1 Neighboring gene ribosomal protein L7a, pseudogene 25 Neighboring gene uncharacterized LOC134484920

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mannose-binding lectin gene polymorphisms as a susceptibility factor for chronic necrotizing pulmonary aspergillosis. Crosdale DJ, et al. J Infect Dis, 2001 Sep 1. PMID 11474427
  2. Complement defects in patients with chronic rhinosinusitis. Gaunsbaek MQ, et al. PLoS One, 2012. PMID 23144819, Free PMC Article
  3. A variant in the promoter of MBL2 is associated with protection against visceral leishmaniasis in Morocco. Hamdi S, et al. Infect Genet Evol, 2013 Jan. PMID 22995279
  4. Development of pulmonary abnormalities in patients with common variable immunodeficiency: associations with clinical and immunologic factors. Gregersen S, et al. Ann Allergy Asthma Immunol, 2010 Jun. PMID 20568383
  5. Epidemiology of chronic wound patients and relation to serum levels of mannan-binding lectin. Bitsch M, et al. Acta Derm Venereol, 2009 Nov. PMID 19997692

See all (135) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables D-mannose binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-mannose binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables galactose binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protease binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface pattern recognition receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within complement activation, lectin pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in complement activation, lectin pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within killing by host of symbiont cells ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of complement activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of opsonization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in surfactant homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
is_active_in multivesicular body IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of serine-type endopeptidase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mannose-binding protein C
Names
MBP-C
RA-reactive factor P28A subunit
RARF/P28A
mannan-binding protein
mannose binding lectin 2 (protein C)
mannose-binding lectin (protein C) 2
mannose-binding protein C (liver)
mannose-binding protein C-like
ra-reactive factor polysaccharide-binding component p28A
raRF p28A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022704.2 → NP_073195.2  mannose-binding protein C precursor

    See identical proteins and their annotated locations for NP_073195.2

    Status: PROVISIONAL

    Source sequence(s)
    X05023
    UniProtKB/Swiss-Prot
    P08661
    UniProtKB/TrEMBL
    A6I0Y6
    Conserved Domains (2) summary
    cd03591
    Location:132 → 242
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
    pfam01391
    Location:36 → 95
    Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    237429873..237465567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231249.4 → XP_006231311.1  mannose-binding protein C isoform X1

    See identical proteins and their annotated locations for XP_006231311.1

    UniProtKB/Swiss-Prot
    P08661
    UniProtKB/TrEMBL
    A6I0Y6
    Related
    ENSRNOP00000047103.7, ENSRNOT00000050984.7
    Conserved Domains (2) summary
    cd03591
    Location:132 → 242
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
    pfam01391
    Location:36 → 95
    Collagen; Collagen triple helix repeat (20 copies)

  2. XM_063272804.1 → XP_063128874.1  mannose-binding protein C isoform X2

  3. XM_006231250.4 → XP_006231312.1  mannose-binding protein C isoform X1

    See identical proteins and their annotated locations for XP_006231312.1

    UniProtKB/Swiss-Prot
    P08661
    UniProtKB/TrEMBL
    A6I0Y6
    Conserved Domains (2) summary
    cd03591
    Location:132 → 242
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
    pfam01391
    Location:36 → 95
    Collagen; Collagen triple helix repeat (20 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08661.2 GenPept UniProtKB/Swiss-Prot:P08661

Gene LinkOut

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