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Gabarapl2 GABA type A receptor associated protein like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64670, updated on 27-Nov-2024

Summary

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Official Symbol
Gabarapl2provided by RGD
Official Full Name
GABA type A receptor associated protein like 2provided by RGD
Primary source
RGD:620510
See related
EnsemblRapid:ENSRNOG00000019425 AllianceGenome:RGD:620510
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gef2
Summary
Predicted to enable phosphatidylethanolamine binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including cellular response to nitrogen starvation; macroautophagy; and negative regulation of proteasomal protein catabolic process. Predicted to be located in Golgi membrane and autophagosome. Predicted to be active in autophagosome membrane. Orthologous to human GABARAPL2 (GABA type A receptor associated protein like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 472.7), Kidney (RPKM 393.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gabarapl2 in Genome Data Viewer
Location:
19q12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (56819826..56830662)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (39910572..39921408)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (44164935..44175771)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene carbohydrate sulfotransferase 5 Neighboring gene transmembrane protein 231 Neighboring gene adenosine deaminase, tRNA-specific 1 Neighboring gene lysyl-tRNA synthetase 1 Neighboring gene TERF2 interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. OSBP-related protein 7 interacts with GATE-16 and negatively regulates GS28 protein stability. Zhong W, et al. Exp Cell Res, 2011 Oct 1. PMID 21669198
  2. Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein. Xin Y, et al. Genomics, 2001 Jun 15. PMID 11414770
  3. The TP53INP2 protein is required for autophagy in mammalian cells. Nowak J, et al. Mol Biol Cell, 2009 Feb. PMID 19056683, Free PMC Article
  4. LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. Kabeya Y, et al. J Cell Sci, 2004 Jun 1. PMID 15169837
  5. GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28. Sagiv Y, et al. EMBO J, 2000 Apr 3. PMID 10747018, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC108686

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylethanolamine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylethanolamine binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular response to nitrogen starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in autophagosome IEA
Inferred from Electronic Annotation
more info
  
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
  
located_in autophagosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in autophagosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in autophagosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
gamma-aminobutyric acid receptor-associated protein-like 2
Names
GABA(A) receptor-associated protein like 2
GATE-16
GEF-2
ganglioside expression factor 2
golgi-associated ATPase enhancer of 16 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022706.2 → NP_073197.1  gamma-aminobutyric acid receptor-associated protein-like 2

    See identical proteins and their annotated locations for NP_073197.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088139
    UniProtKB/Swiss-Prot
    P60522
    UniProtKB/TrEMBL
    A6IZB7
    Related
    ENSRNOP00000040067.3, ENSRNOT00000048998.5
    Conserved Domains (1) summary
    cd17163
    Location:5 → 116
    Ubl_ATG8_GABARAPL2; ubiquitin-like (Ubl) domain found in GABA type A receptor associated protein like 2 (GABARAPL2, also known as GATE16)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    56819826..56830662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60522.1 GenPept UniProtKB/Swiss-Prot:P60522

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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