eIF2D eukaryotic translation initiation factor 2D [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: eIF2Dprovided by FlyBase
Official Full Name: eukaryotic translation initiation factor 2Dprovided by FlyBase
Primary source: FLYBASE:FBgn0041588
Locus tag: Dmel_CG31426
See related: AllianceGenome:FB:FBgn0041588
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:LD24540; CG31426; Dmel\CG31426; ligatin
Summary: Predicted to enable translation initiation factor activity. Predicted to be involved in formation of translation preinitiation complex and ribosome disassembly. Predicted to be located in cytoplasm. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; embryonic/larval midgut; embryonic/larval midgut primordium; and head mesoderm. Orthologous to human EIF2D (eukaryotic translation initiation factor 2D). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29149896..29151794, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (24975618..24977516, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR.
Title: Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in formation of translation preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in formation of translation preinitiation complex	IEA Inferred from Electronic Annotation more info
involved_in ribosome disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

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The following sections contain reference sequences that belong to a specific genome build. Explain