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Adgf-A2 Adenosine deaminase-related growth factor A2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 64879, updated on 9-Dec-2024

Summary

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Official Symbol
Adgf-A2provided by FlyBase
Official Full Name
Adenosine deaminase-related growth factor A2provided by FlyBase
Primary source
FLYBASE:FBgn0043025
Locus tag
Dmel_CG32178
See related
AllianceGenome:FB:FBgn0043025
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ADGF-A2; BcDNA:AT05468; CG32178; Dmel\CG32178; Msi; MSI
Summary
Predicted to enable adenosine deaminase activity. Involved in spermatid development. Located in membrane. Is expressed in adult head; spermatid; spermatocyte; spermatozoon; and testis. Human ortholog(s) of this gene implicated in Sneddon syndrome. Orthologous to human ADA2 (adenosine deaminase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Adgf-A2 in Genome Data Viewer
Location:
75A1-75A1; 3-45 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17754936..17764158, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17748036..17757258, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ccn Neighboring gene uncharacterized protein Neighboring gene Adenosine deaminase-related growth factor B Neighboring gene Adenosine deaminase-related growth factor A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44668 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Male-specific IDGF, a novel gene encoding a membrane-bound extracellular signaling molecule expressed exclusively in testis of Drosophila melanogaster. Matsushita T, et al. J Biol Chem, 2000 Nov 24. PMID 10967093
  2. Genetic analysis of the ADGF multigene family by homologous recombination and gene conversion in Drosophila. Dolezal T, et al. Genetics, 2003 Oct. PMID 14573477, Free PMC Article
  3. Expression of Drosophila adenosine deaminase in immune cells during inflammatory response. Novakova M, et al. PLoS One, 2011 Mar 11. PMID 21412432, Free PMC Article
  4. Adenosine deaminase-related growth factors stimulate cell proliferation in Drosophila by depleting extracellular adenosine. Zurovec M, et al. Proc Natl Acad Sci U S A, 2002 Apr 2. PMID 11904370, Free PMC Article
  5. Increased extracellular adenosine in Drosophila that are deficient in adenosine deaminase activates a release of energy stores leading to wasting and death. Zuberova M, et al. Dis Model Mech, 2010 Nov-Dec. PMID 20940317

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenosine deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables adenosine deaminase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenosine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenosine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in adenosine catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in inosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatid development IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
adenosine deaminase-related growth factor A2
Names
Adgf-A2-PA
Adgf-A2-PB
Adgf-A2-PC
CG32178-PA
CG32178-PB
CG32178-PC
Male-specific insect derived growth factor
male-specific IDGF
male-specific-imaginal-disc-growth-factor
NP_001036612.1
NP_001036613.1
NP_525020.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    17754936..17764158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001043148.2 → NP_001036613.1  adenosine deaminase-related growth factor A2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036613.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E8D8, Q8IHF6, Q9GRE6
    Conserved Domains (3) summary
    cd01321
    Location:116 → 529
    ADGF; Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors with sequence similarty to adenosine deaminase.
    TIGR01431
    Location:64 → 537
    adm_rel; adenosine deaminase-related growth factor
    pfam08451
    Location:33 → 133
    A_deaminase_N; Adenosine/AMP deaminase N-terminal

  2. NM_001043147.2 → NP_001036612.1  adenosine deaminase-related growth factor A2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036612.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E8D8, Q8IHF6, Q9GRE6
    Conserved Domains (3) summary
    cd01321
    Location:116 → 529
    ADGF; Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors with sequence similarty to adenosine deaminase.
    TIGR01431
    Location:64 → 537
    adm_rel; adenosine deaminase-related growth factor
    pfam08451
    Location:33 → 133
    A_deaminase_N; Adenosine/AMP deaminase N-terminal

  3. NM_080281.3 → NP_525020.2  adenosine deaminase-related growth factor A2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525020.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IHF6, Q8IQR3, Q9GRE6
    Related
    FBpp0074956
    Conserved Domains (3) summary
    cd01321
    Location:135 → 548
    ADGF; Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors with sequence similarty to adenosine deaminase.
    TIGR01431
    Location:83 → 556
    adm_rel; adenosine deaminase-related growth factor
    pfam08451
    Location:52 → 152
    A_deaminase_N; Adenosine/AMP deaminase N-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0E8D8 Q0E8D8
Q8IHF6 Q8IHF6
Q8IQR3 Q8IQR3
Q9GRE6 Q9GRE6

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