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MRPL36 mitochondrial ribosomal protein L36 [ Homo sapiens (human) ]

Gene ID: 64979, updated on 27-Nov-2024

Summary

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Official Symbol
MRPL36provided by HGNC
Official Full Name
mitochondrial ribosomal protein L36provided by HGNC
Primary source
HGNC:HGNC:14490
See related
Ensembl:ENSG00000171421 MIM:611842; AllianceGenome:HGNC:14490
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RPMJ; BRIP1; L36mt; bL36m; PRPL36; MRP-L36
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 2p. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 15.3), adrenal (RPKM 7.9) and 25 other tissues See more
Orthologs
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Genomic context

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See MRPL36 in Genome Data Viewer
Location:
5p15.33
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (1798385..1801434, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (1713255..1716322, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (1798499..1799951, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374614 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:1708852-1709007 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1708971-1709534 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1709535-1710099 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1710100-1710663 Neighboring gene microRNA 4277 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1745447-1745946 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1751136-1751775 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1768734-1769442 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1769443-1770149 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1771839-1772338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22308 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22309 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22311 Neighboring gene uncharacterized LOC101929003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22312 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15888 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22313 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22314 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:1801330-1802317 Neighboring gene NADH:ubiquinone oxidoreductase subunit S6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1815894-1816405 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1817127-1817628 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1817629-1818128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1827503-1828018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1828019-1828534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1831287-1831980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1831981-1832674 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1833787-1834780 Neighboring gene VISTA enhancer hs2567 Neighboring gene eukaryotic translation initiation factor 3 subunit A Neighboring gene long intergenic non-protein coding RNA 2116

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. BACH1 is a DNA repair protein supporting BRCA1 damage response. Peng M, et al. Oncogene, 2006 Apr 6. PMID 16462773
  2. Association of LETM1 and MRPL36 contributes to the regulation of mitochondrial ATP production and necrotic cell death. Piao L, et al. Cancer Res, 2009 Apr 15. PMID 19318571
  3. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. Kenmochi N, et al. Genomics, 2001 Sep. PMID 11543634
  4. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. Suzuki T, et al. J Biol Chem, 2001 Jun 15. PMID 11279069
  5. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. Hu RM, et al. Proc Natl Acad Sci U S A, 2000 Aug 15. PMID 10931946, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
  2. MRPL36 contributes to the regulation of mitochondrial ATP production and necrotic cell death.
    Title: Association of LETM1 and MRPL36 contributes to the regulation of mitochondrial ATP production and necrotic cell death.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC104245

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
  
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HTP PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein bL36m
Names
39S ribosomal protein L36, mitochondrial
BRCA1-interacting protein 1
mitochondrial large ribosomal subunit protein bL36m
putative BRCA1-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032479.4 → NP_115868.1  large ribosomal subunit protein bL36m

    See identical proteins and their annotated locations for NP_115868.1

    Status: REVIEWED

    Source sequence(s)
    BC104652, BG185418
    Consensus CDS
    CCDS3865.1
    UniProtKB/Swiss-Prot
    A4UCS0, B2R4Z2, Q3SWV6, Q9P0J6, Q9UKL7
    Related
    ENSP00000423152.1, ENST00000505059.7
    Conserved Domains (1) summary
    pfam00444
    Location:66 → 103
    Ribosomal_L36; Ribosomal protein L36

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    1798385..1801434 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514080.3 → XP_011512382.1  large ribosomal subunit protein bL36m isoform X2

    Conserved Domains (1) summary
    pfam00444
    Location:81 → 118
    Ribosomal_L36; Ribosomal protein L36

  2. XM_017009751.3 → XP_016865240.1  large ribosomal subunit protein bL36m isoform X3

    UniProtKB/Swiss-Prot
    A4UCS0, B2R4Z2, Q3SWV6, Q9P0J6, Q9UKL7
    Conserved Domains (1) summary
    pfam00444
    Location:66 → 103
    Ribosomal_L36; Ribosomal protein L36

  3. XM_017009750.2 → XP_016865239.1  large ribosomal subunit protein bL36m isoform X3

    UniProtKB/Swiss-Prot
    A4UCS0, B2R4Z2, Q3SWV6, Q9P0J6, Q9UKL7
    Related
    ENSP00000372093.6, ENST00000382647.7
    Conserved Domains (1) summary
    pfam00444
    Location:66 → 103
    Ribosomal_L36; Ribosomal protein L36

  4. XM_017009752.2 → XP_016865241.1  large ribosomal subunit protein bL36m isoform X3

    UniProtKB/Swiss-Prot
    A4UCS0, B2R4Z2, Q3SWV6, Q9P0J6, Q9UKL7
    Related
    ENSP00000423399.1, ENST00000508987.1
    Conserved Domains (1) summary
    pfam00444
    Location:66 → 103
    Ribosomal_L36; Ribosomal protein L36

  5. XM_011514079.2 → XP_011512381.1  large ribosomal subunit protein bL36m isoform X1

    Conserved Domains (1) summary
    pfam00444
    Location:132 → 169
    Ribosomal_L36; Ribosomal protein L36

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    1713255..1716322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353182.1 → XP_054209157.1  large ribosomal subunit protein bL36m isoform X2

  2. XM_054353186.1 → XP_054209161.1  large ribosomal subunit protein bL36m isoform X3

    UniProtKB/Swiss-Prot
    A4UCS0, B2R4Z2, Q3SWV6, Q9P0J6, Q9UKL7

  3. XM_054353184.1 → XP_054209159.1  large ribosomal subunit protein bL36m isoform X3

    UniProtKB/Swiss-Prot
    A4UCS0, B2R4Z2, Q3SWV6, Q9P0J6, Q9UKL7

  4. XM_054353183.1 → XP_054209158.1  large ribosomal subunit protein bL36m isoform X3

    UniProtKB/Swiss-Prot
    A4UCS0, B2R4Z2, Q3SWV6, Q9P0J6, Q9UKL7

  5. XM_054353185.1 → XP_054209160.1  large ribosomal subunit protein bL36m isoform X3

    UniProtKB/Swiss-Prot
    A4UCS0, B2R4Z2, Q3SWV6, Q9P0J6, Q9UKL7

  6. XM_054353181.1 → XP_054209156.1  large ribosomal subunit protein bL36m isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P0J6.1 GenPept UniProtKB/Swiss-Prot:Q9P0J6

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