Sfxn3 sideroflexin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sfxn3provided by RGD
Official Full Name: sideroflexin 3provided by RGD
Primary source: RGD:620716
See related: EnsemblRapid:ENSRNOG00000015442 AllianceGenome:RGD:620716
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TCC; SLC64A3
Summary: Predicted to enable L-serine transmembrane transporter activity. Predicted to be involved in serine import into mitochondrion. Located in mitochondrial membrane. Orthologous to human SFXN3 (sideroflexin 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Lung (RPKM 94.5), Brain (RPKM 88.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (253856935..253866219)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (243907958..243917065)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (264796671..264805159)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sideroflexin 3 is a Mitochondrial Protein Enriched in Neurons.
Title: Sideroflexin 3 is a Mitochondrial Protein Enriched in Neurons.
citrate transporter protein-like protein/Sfxn3 and some other family members might be important in the differentiation of pancreatic beta-cells
Title: Roles of CTPL/Sfxn3 and Sfxn family members in pancreatic islet.
TCC protein as well as mRNA was widely expressed in brain, and the protein expression was strong in neuronal cells in the hippocampus, the olfactory bulb, the corpus mamillare and the cerebellum.
Title: Expression of mitochondrial tricarboxylate carrier TCC mRNA and protein in the rat brain.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Rat81 (e-PCR), detects polymorphism
- UniSTS:118617

D1Rat374 (e-PCR), detects polymorphism
- UniSTS:227162

D1Rat453 (e-PCR), detects polymorphism
- UniSTS:227235

d1rat375 (e-PCR)
- UniSTS:121516

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-serine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-serine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-serine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables monoatomic ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables tricarboxylate secondary active transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in L-serine transport	IEA Inferred from Electronic Annotation more info
involved_in amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in mitochondrial transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in one-carbon metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of one-carbon metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of one-carbon metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in serine import into mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in serine import into mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in serine import into mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in serine import into mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sideroflexin-3

Names: solute carrier family 64 member 3; tricarboxylate carrier; tricarboxylate carrier-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.